Catalog No.
YHG29001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe22-Trp435
Predicted molecular weight
48.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q12794
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LuCa-1, HYAL1, Hyaluronidase-1, Hyal-1, LUCA1, Lung carcinoma protein 1, Hyaluronoglucosaminidase-1
Succinylation-related molecular activities in cancer: metabolic adaptations, immune landscape, and prognostic significance in colorectal cancer., PMID:40463370
DBI as a Novel Immunotherapeutic Candidate in Colorectal Cancer: Dissecting Genetic Risk and the Immune Landscape via GWAS, eQTL, and pQTL., PMID:40426943
In Vitro and In Vivo Evaluation of an Emollient-Rich Moisturizer Developed to Address Three Critical Elements of Natural Moisturization., PMID:40176773
Extracellular matrix dynamics in a rat model of pulmonary arterial hypertension: unveiling the role of hyaluronan in disease pathology., PMID:40079867
Lithospermum erythrorhizon and Forsythia suspensa Prevent Collagen Degradation and Maintain Skin Hydration by Regulating MMPs and HAS2/HYAL1 Signaling., PMID:40076307
Relationship between fat embolism and endothelial glycocalyx., PMID:39383615
Substitution of acidic residues near the catalytic Glu131 leads to human HYAL1 activity at neutral pH via charge-charge interactions., PMID:39121049
Genetic Deficiencies of Hyaluronan Degradation., PMID:39056785
Kunzea Ericoides (Kanuka) Leaf Extracts Show Moisturisation, Antioxidant, and UV Protection Effects in HaCaT Cells and Anti-melanogenesis Effects in B16F10 Cells., PMID:39009952
Apple Pomace Extract Induces Cell Proliferation and Increases Type I Collagen and Hyaluronan Production in Human Skin Fibroblasts In Vitro., PMID:39001986
Clinicopathological significance of hyaluronan and hyaluronidase 2 (HYAL2) in breast cancer., PMID:38991455
Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3., PMID:38844132
Cyclosporin A inhibits PDGF-BB induced hyaluronan synthesis in orbital fibroblasts., PMID:38729283
WNT5B drives osteosarcoma stemness, chemoresistance and metastasis., PMID:38689429
Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells., PMID:38490466
Tumor-derived exosomal hyaluronidase 1 induced M2 macrophage polarization and promoted esophageal cancer progression., PMID:38382806
Photoprotective effects of Lithospermum erythrorhizon and Pueraria lobata extracts on UVB-induced photoaging: A study on skin barrier protection., PMID:38288763
Programmed Death-Ligand (PD-L1), Epidermal Growth Factor (EGF), Relaxin, and Matrix Metalloproteinase-3 (MMP3): Potential Biomarkers of Malignancy in Canine Mammary Neoplasia., PMID:38256245
High prevalence of CD44 and its ligand low molecular weight hyaluronan in plasma of HNSCC patients: clinical significance., PMID:38252332
DNA Methylation Status of HYAL1 in Malignant and Benign Thyroid Nodules., PMID:38040022
Expression analysis of genes important for maintaining skin function in a senescence-accelerated mouse prone model., PMID:37908183
Inhibition of hyaluronic acid degradation pathway suppresses glioma progression by inducing apoptosis and cell cycle arrest., PMID:37568202
HYAL1 deficiency attenuates lipopolysaccharide-triggered renal injury and endothelial glycocalyx breakdown in septic AKI in mice., PMID:37563795
Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma., PMID:37334363
Targeting BET Proteins Decreases Hyaluronidase-1 in Pancreatic Cancer., PMID:37296612
Low-Molecular-Weight Hyaluronic Acid Contributes to Noise-Induced Cochlear Inflammation., PMID:37231777
Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves' Orbitopathy., PMID:36615214
Key Role of Hyaluronan Metabolism for the Development of Brain Metastases in Triple-Negative Breast Cancer., PMID:36291142
Characterization of Hyaluronidase 4 Involved in the Catabolism of Chondroitin Sulfate., PMID:36144836
Enhanced anti-wrinkle activity of adlay bran fermented with Lactobacillus brevis MJM60390., PMID:35946116
Hyal1 Expression in Colorectal Carcinoma Cell Migration and Invasiveness: Significance and Mechanism., PMID:35836827
In vitro assessment of the anti-inflammatory and skin-moisturizing effects of Filipendula palmata (Pall.) Maxim. On human keratinocytes and identification of its bioactive phytochemicals., PMID:35809756
The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer., PMID:35767191
Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4., PMID:35662287
In Vitro Anti-Photoaging and Skin Protective Effects of Licania macrocarpa Cuatrec Methanol Extract., PMID:35631808
Hyaluronan in articular cartilage: Analysis of hip osteoarthritis and osteonecrosis of femoral head., PMID:35538609
The Degradation of Hyaluronan in the Skin., PMID:35204753
Effects of the epidermal growth factor receptor inhibitor, gefitinib, on lipid and hyaluronic acid synthesis in cultured HaCaT keratinocytes., PMID:35122447
In Vitro Photoprotective, Anti-Inflammatory, Moisturizing, and Antimelanogenic Effects of a Methanolic Extract of Chrysophyllum lucentifolium Cronquist., PMID:35009097
Hyaluronan size alters chondrogenesis of mesenchymal stem cells cultured on tricalcium phosphate-collagen-hyaluronan scaffolds., PMID:34859573
Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0., PMID:34716342
Urine Biomarkers for the Diagnosis of Bladder Cancer: a Network Meta-Analysis., PMID:34585369
Hypoxia increases KIAA1199/CEMIP expression and enhances cell migration in pancreatic cancer., PMID:34521918
Prediction of a Potential Mechanism of Intervertebral Disc Degeneration Based on a Novel Competitive Endogenous RNA Network., PMID:34307661
An epigenome-wide DNA methylation study of patients with COVID-19., PMID:34185889
Downregulation of Hyaluronic acid-CD44 signaling pathway in cervical cancer cell by natural polyphenols Plumbagin, Pongapin and Karanjin., PMID:34081254
Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies., PMID:33946287
A nonsynonymous polymorphism (rs117179004, T392M) of hyaluronidase 1 (HYAL1) is associated with increased risk of idiopathic pulmonary fibrosis in Southern Han Chinese., PMID:33942374
Abundance and size of hyaluronan in naked mole-rat tissues and plasma., PMID:33846452
Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells., PMID:33543028
For research use only. Not for human or drug use.
