Catalog No.
YHG17901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu23-Ile312
Predicted molecular weight
36.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08830
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Liver fibrinogen-related protein 1, HFREP-1, HP-041, Hepatocyte-derived fibrinogen-related protein 1, HPS, FGL1, LFIRE-1, Hepassocin, Fibrinogen-like protein 1, HFREP1
Effect of a Laparoscopic Donor Nephrectomy in Healthy Living Kidney Donors on the Acute Phase Response Using Either Propofol or Sevoflurane Anesthesia., PMID:40508008
Silencing FGL1 promotes prostate cancer cell apoptosis and inhibits EMT progression., PMID:40481127
Comprehensive analysis of the functional and immunological significance of ETV4 in pan-cancer and its validation in digestive tumors., PMID:40469297
FGL-1 Modulates Inter-Organ Communication by Controlling T Cell Homeostasis during the Onset of Sjögren's Disease., PMID:40395191
Research advances in FGL1/LAG3 for cancer diagnosis and treatment: From basics to clinical practice., PMID:40317138
Pan-cancer analysis of co-inhibitory molecules revealing their potential prognostic and clinical values in immunotherapy., PMID:40196117
Design of NanoBiT-Nanobody-based FGL1 biosensors for early assisted diagnosis of esophageal cancer., PMID:40138964
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs., PMID:40101708
Tumor-intrinsic PRMT5 upregulates FGL1 via methylating TCF12 to inhibit CD8+ T-cell-mediated antitumor immunity in liver cancer., PMID:40041915
Genetic insights into CRP levels in Indian adolescents: confirming adult genetic associations., PMID:39843866
Circulating proteomic profiles are associated with type 2 diabetes in Asian populations - a longitudinal study., PMID:39842943
Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1., PMID:39778025
FGL1 facilitates rather than suppresses anticancer immunity against microsatellite instable gastric cancer., PMID:39672971
The FGL-1/LAG-3 Axis is Associated With Disease Course in Alcohol-associated Hepatitis: A Preliminary Report., PMID:39553834
Precision medicine in diabetes prediction: Exploring a subgroup-specific biomarker strategy for risk stratification., PMID:39535373
Comparative Analysis of Plasma Protein Dynamics in Women with ST-Elevation Myocardial Infarction and Takotsubo Syndrome., PMID:39513871
Carvacrol potentiates immunity and sorafenib anti-cancer efficacy by targeting HIF-1α/STAT3/ FGL1 pathway: in silico and in vivo study., PMID:39466438
Cancer-associated fibroblast-secreted exosomes promote prostate cancer cell migration and invasion by the FGL1/SOX5 axis., PMID:39463328
HDAC inhibitor SAHA enhances antitumor immunity via the HDAC1/JAK1/FGL1 axis in lung adenocarcinoma., PMID:39384195
Yap methylation-induced FGL1 expression suppresses anti-tumor immunity and promotes tumor progression in KRAS-driven lung adenocarcinoma., PMID:39340215
Unlocking therapeutic potential: Targeting lymphocyte activation Gene-3 (LAG-3) with fibrinogen-like protein 1 (FGL1) in systemic lupus erythematosus., PMID:39228513
Vibrio splendidus infection promotes circRNA-FGL1-regulated coelomocyte apoptosis via competitive binding to Myc with the deubiquitinase OTUB1 in Apostichopus japonicus., PMID:39146353
Pan-cancer analysis of immune checkpoint receptors and ligands in various cells in the tumor immune microenvironment., PMID:39120585
Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia., PMID:39119725
FGL1: a novel biomarker and target for non-small cell lung cancer, promoting tumor progression and metastasis through KDM4A/STAT3 transcription mechanism., PMID:39085849
Impact of LAG-3/FGL1 pathway on immune evasive contexture and clinical outcomes in advanced urothelial carcinoma., PMID:39043605
Hepatocyte-derived FGL1 accelerates liver metastasis and tumor growth by inhibiting CD8+ T and NK cells., PMID:38973608
FGL2 as a predictive biomarker for prognosis and immunotherapy in bladder cancer., PMID:38903931
Synthesis and Characterization of a Novel PET Tracer for Noninvasive Evaluation of FGL1 Status in Tumors., PMID:38836286
FGL1 and FGL2: emerging regulators of liver health and disease., PMID:38816776
A novel LAG3 neutralizing antibody improves cancer immunotherapy by dual inhibition of MHC-II and FGL1 ligand binding., PMID:38776682
Potential clinical value of fibrinogen-like protein 1 as a serum biomarker for the identification of diabetic cardiomyopathy., PMID:38705920
Radiation-induced upregulation of FGL1 promotes esophageal squamous cell carcinoma metastasis via IMPDH1., PMID:38702629
Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy., PMID:38638375
Inhibition of USP7 enhances CD8+ T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation., PMID:38589688
The immune checkpoint receptor LAG3: Structure, function, and target for cancer immunotherapy., PMID:38556085
Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy., PMID:38486998
Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function., PMID:38483996
Systematic review and bioinformatics analysis of plasma and serum extracellular vesicles proteome in type 2 diabetes., PMID:38356516
Immunological characterization of a long-lasting response in a patient with metastatic triple-negative breast cancer treated with PD-1 and LAG-3 blockade., PMID:38336861
The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling., PMID:38232308
FGL1 in plasma extracellular vesicles is correlated with clinical stage of lung adenocarcinoma and anti-PD-L1 response., PMID:38146642
Advances in tumor immunomodulation based on nanodrug delivery systems., PMID:38106403
[Screening and activity analysis of nanobodies against lymphocyte activation gene-3(LAG-3)]., PMID:37980554
FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation., PMID:37938970
FGL1-LAG3 axis impairs IL-10-Producing regulatory T cells associated with Systemic lupus erythematosus disease activity., PMID:37916085
FGL1 Promotes Tumor Immune Escape in Stomach Adenocarcinoma via the Notch Signaling Pathway., PMID:37902887
The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer., PMID:37872170
Increased FGL1 Expression Predicts Poor Prognosis and Promotes EMT in Head and Neck Squamous Cell Carcinoma., PMID:37843652
Comprehensive immunophenotyping of solid tumor-infiltrating immune cells reveals the expression characteristics of LAG-3 and its ligands., PMID:37795090
For research use only. Not for human or drug use.
