Catalog No.
YHG17501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly21-Arg183
Predicted molecular weight
20.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08708
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IgSF16, CD300c, CMRF-35, CMRF35-like molecule 6, CMRF35A1, CMRF35A, CD300C, Immunoglobulin superfamily member 16, IGSF16, CLM-6, CMRF35, CMRF35-A1, CD300 antigen-like family member C
The Combination of CD300c Antibody with PD-1 Blockade Suppresses Tumor Growth and Metastasis by Remodeling the Tumor Microenvironment in Triple-Negative Breast Cancer., PMID:40507854
Engagement of CD300c by a Novel Monoclonal Antibody Ameliorates Behavioral Deficits in a 5xFAD Mouse Model of Alzheimer's Disease., PMID:40426995
Engagement of CD300c by a novel monoclonal antibody induces the differentiation of monocytes to M1 macrophages., PMID:38159528
Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma., PMID:37666053
Model for predicting immunotherapy based on M2 macrophage infiltration in TNBC., PMID:36999020
pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells., PMID:36827419
Recombinant CD300c-Ig fusion protein attenuates collagen-induced arthritis in mice., PMID:34021311
T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19., PMID:33777054
Genetic Correlation Analysis and Transcriptome-wide Association Study Suggest the Overlapped Genetic Mechanism between Gout and Attention-deficit Hyperactivity Disorder., PMID:33155823
Cutting Edge: Involvement of the Immunoreceptor CD300c2 on Alveolar Macrophages in Bleomycin-Induced Lung Fibrosis., PMID:31757863
Distinguishing human peripheral blood CD16+ myeloid cells based on phenotypic characteristics., PMID:31749181
A CD300c-Fc Fusion Protein Inhibits T Cell Immunity., PMID:30498497
CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy., PMID:29906528
Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells., PMID:29844322
Pertussis toxin targets the innate immunity through DAP12, FcRγ, and MyD88 adaptor proteins., PMID:28089363
Neonatal monocytes exhibit a unique histone modification landscape., PMID:27660665
The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adults., PMID:27595670
Antibody to CMRF35-Like Molecule 2, CD300e A Novel Biomarker Detected in Patients with Fulminant Type 1 Diabetes., PMID:27513516
CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition., PMID:27040328
Bariatric Surgery Induces Disruption in Inflammatory Signaling Pathways Mediated by Immune Cells in Adipose Tissue: A RNA-Seq Study., PMID:25938420
The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells., PMID:23640773
CD300c is an activating receptor expressed on human monocytes., PMID:23571507
Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition., PMID:23372157
Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain., PMID:22442068
Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors., PMID:22291008
Differential expression of CD300a/c on human TH1 and TH17 cells., PMID:22046970
Stimulation of FasL induces production of proinflammatory mediators through activation of mitogen-activated protein kinases and nuclear factor-κB in THP-1 cells., PMID:21152963
CD300 heterocomplexes, a new and family-restricted mechanism for myeloid cell signaling regulation., PMID:20959446
Expression and function of CD300 in NK cells., PMID:20656921
CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands., PMID:18535206
Novel human CD4+ T lymphocyte subpopulations defined by CD300a/c molecule expression., PMID:17702825
Monocytes immunoselected via the novel monocyte specific molecule, CD300e, differentiate into active migratory dendritic cells., PMID:17414321
Expression, crystallization and X-ray data collection from microcrystals of the extracellular domain of the human inhibitory receptor expressed on myeloid cells IREM-1., PMID:17329815
The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1., PMID:17275839
The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase., PMID:17202342
Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways., PMID:16920917
CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium., PMID:16876123
Molecular characterization of a novel immune receptor restricted to the monocytic lineage., PMID:15557162
IREM-1 is a novel inhibitory receptor expressed by myeloid cells., PMID:15549731
CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation., PMID:14662855
CMRF-35A, CMRF-35H: potential new CD., PMID:12456026
The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family., PMID:11556966
For research use only. Not for human or drug use.
