Catalog No.
YHG16501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Cys335
Predicted molecular weight
39.81 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08431
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MFGM, HMFG, MFG-E8, MFGE8, SED1, Milk fat globule-EGF factor 8, Breast epithelial antigen BA46, Lactadherin
Note
For research use only.
MFGE8 in exosomes derived from mesenchymal stem cells prevents esophageal stricture after endoscopic submucosal dissection in pigs., PMID:38561800
The Novel MFG-E8-derived Oligopeptide, MOP3, Improves Outcomes in a Preclinical Murine Model of Neonatal Sepsis., PMID:38582704
Identification of chemoresistance associated key genes-miRNAs-TFs in docetaxel resistant breast cancer by bioinformatics analysis., PMID:38590544
TAG-FREE GLYCOSYLATED RHMFG-E8 AS A THERAPY FOR ACUTE KIDNEY INJURY., PMID:38691106
Correlation of Serum and Gingival Crevicular Fluid Levels of Caspase-3 and Milk Fat Globule-Epidermal Growth Factor 8 on Gingival Health., PMID:38739812
COMT Variants are Associated With Breast and Nipple Pain., PMID:38763257
Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis., PMID:38802814
Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages., PMID:38830798
Contribution of circulating Mfge8 to human T2DM and cardiovascular disease., PMID:38901535
RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway., PMID:38995840
Milk Fat Globule-EGF Factor 8 (MFGE8) Mitigates Cognitive Impairment in Rats with Sepsis-Associated Encephalopathy: An fMRI Study., PMID:39082291
Microglia through MFG-E8 signaling decrease the density of degenerating neurons and protect the brain from the development of cortical infarction after stroke., PMID:39110702
MFGE8 promotes adult hippocampal neurogenesis in rats following experimental subarachnoid hemorrhage via modifying the integrin β3/Akt signaling pathway., PMID:39128910
Investigating Medin Cleavage Accessibility in MfgE8: Conformational Insights Derived from Molecular Dynamics Simulations and AlphaFold2 Models., PMID:39131300
Computational insights into the aggregation mechanism and amyloidogenic core of aortic amyloid medin polypeptide., PMID:39226847
Glia maturation factor-γ regulates amyloid-β42 phagocytosis through scavenger receptor class A type I in murine macrophages., PMID:39243388
Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8., PMID:39305336
MFG-E8 Ameliorates Nerve Injury-Induced Neuropathic Pain by Regulating Microglial Polarization and Neuroinflammation via Integrin β3/SOCS3/STAT3 Pathway in Mice., PMID:39305375
Milk fat globule EGF and factor V/VIII domain containing-mediated osteoimmunology in periodontal disease., PMID:39321103
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia., PMID:39361088
Medin, a link between vascular pathology and dementia?, PMID:39370976
Phosphatidylserine-mediated uptake of extracellular vesicles by hepatocytes ameliorates liver ischemia-reperfusion injury., PMID:39397123
The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation., PMID:39452123
Milk fat globule-epidermal growth factor-VIII-derived oligopeptide 3 (MOP3) attenuates inflammation and improves survival in hepatic ischemia/reperfusion injury., PMID:39455391
Rapid increase of MFGE8 secretion from endometrial epithelial cells is an indicator of extracellular vesicle mediated embryo maternal dialogue., PMID:39472639
Milk Fat Globules: 2024 Updates., PMID:39474586
MFGE8 promotes gastric cancer progression by activating the IL-6/JAK/STAT3 signaling., PMID:39490801
Milk fat globule-epidermal growth factor 8 exerts anti-osteoarthritis effects by inhibiting apoptosis and inducing autophagy in mouse chondrocytes., PMID:39608050
Potentiating microglial efferocytosis by MFG-E8 improves survival and neurological outcome after successful cardiopulmonary resuscitation in mice., PMID:39717017
Proteomic Analysis of Mesenchymal Stem Cell-derived Exosomes in Psoriasis., PMID:39779548
Acetylation-ubiquitination crosstalk of DJ-1 mediates microcalcification formation in diabetic plaques via collagen-matrix vesicles interaction., PMID:39786474
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis., PMID:39813006
MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1., PMID:39842432
MFGE8 Acts as a Cell Adhesion Factor for Human-Induced Pluripotent Stem Cells in Embryology., PMID:39869126
Isolation of Human BAMBIhighMFGE8high Umbilical Cord-Derived Mesenchymal Stromal Cells., PMID:39878935
Emerging Roles for MFG-E8 in Synapse Elimination., PMID:39891478
Genistein alleviates rheumatoid arthritis by inhibiting fibroblast-like synovial exosome secretion regulated by the Rab27/nSMase2/Mfge8 pathway., PMID:39895262
The role of CTGF and MFG-E8 in the prognosis assessment of SCAP: a study combining machine learning and nomogram analysis., PMID:39917305
Phosphatidylserine induce thrombotic tendency and liver damage in obstructive jaundice., PMID:40050731
Porcine milk small extracellular vesicles modulate peripheral blood mononuclear cell proteome in vitro., PMID:40055486
Osteosarcoma Cell-Derived Migrasomes Promote Macrophage M2 Polarization to Aggravate Osteosarcoma Proliferation and Metastasis., PMID:40056029
[The regulation and mechanism of apolipoprotein A5 on myocardial lipid deposition]., PMID:40065613
MFGE-8, a Corona Protein on Extracellular Vesicles, Mediates Self-Renewal and Survival of Human Pluripotent Stem Cells., PMID:40130745
BTN3A2 interacted with MFGE8 to alleviate preeclampsia by promoting ferroptosis and inhibiting angiogenesis., PMID:40147528
Identifying Potential Drug Targets in Coronary Atherosclerosis: Insights from the Druggable Genome and Mendelian Randomization., PMID:40214710
Xin-shu-bao tablets ameliorates ventricular remodeling against HFrEF via PPARγ/MFGE8 pathway based on MALDI-MSI and lipidomics., PMID:40216048
MFGE8 regulates the EndoMT of HLMECs through the BMP signaling pathway and fibrosis in acute lung injury., PMID:40223052
An enzyme-proof glycan glue for extracellular matrix to ameliorate intervertebral disc degeneration., PMID:40240357
The Age-dependent Influence of the Infrapatellar Fat Pad on Chondrocyte Extracellular Matrix Production., PMID:40375383
Association of the single-nucleotide polymorphism in the MFG-E8 gene with coronary heart disease in Chinese Han population., PMID:40413414
For research use only. Not for human or drug use.
