Catalog No.
YHG16301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu369-Ser574
Predicted molecular weight
25.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08397
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lysyl oxidase homolog 1, LOXL1, LOXL, Lysyl oxidase-like protein 1, LOL
Extracellular Matrix Alterations in Chronic Ischemic Cardiomyopathy Revealed by Quantitative Proteomics., PMID:40501991
Enhancing Prognostic Signatures in Glioblastoma with Feature Selection and Regularised Cox Regression., PMID:40428295
Epithelial-Mesenchymal Plasticity in the D-Meso-Sonobe Mesothelioma Cell Line: A Putative Model of Epithelial-Mesenchymal Transition in Mesothelioma., PMID:40396518
Protein misfolding and mitochondrial dysfunction in glaucoma., PMID:40385286
Integrative bioinformatics analysis and experimental validation of key biomarkers driving the progression of cirrhotic portal hypertension., PMID:40321824
Statement of Retraction: The LOXL1 antisense RNA 1 (LOXL1-AS1)/microRNA-423-5p (miR-423-5p)/ectodermal-neural cortex 1 (ENC1) axis promotes cervical cancer through the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway., PMID:40263947
HIF-1α/LTBP2 axis activate HSCs to promote liver fibrosis by interacting with LOXL1 via the ERK pathway., PMID:40244455
Machine learning-based in-silico analysis identifies signatures of lysyl oxidases for prognostic and therapeutic response prediction in cancer., PMID:40186284
In vitro investigation of epigenetic regulators related to chemo-resistance and stemness of CD133+VE cells sorted from U87MG cell line., PMID:40157620
PRMT1-mediated modification of H4R3me2a promotes liver cancer progression by enhancing the transcriptional activity of SOX18., PMID:40130992
Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker., PMID:40052860
The Oncogenic role of Lysyl Oxidase-Like 1 (LOXL1): Insights into cancer progression and therapeutic potential., PMID:39952484
Lysyl Oxidase as a Target to Reduce Graft Failure Post Solid Organ Transplantation, a Potential Target for Novel Treatment., PMID:39901551
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1., PMID:39812768
Association between gene polymorphisms and glaucoma susceptibility among Africans: a systematic review and meta-analysis., PMID:39757584
Pulmonary lysyl oxidase expression and its role in seeding Lewis lung carcinoma cells., PMID:39714512
Lysyl oxidase inhibitors in colorectal cancer progression., PMID:39675250
A Genome-Wide Association Study and Rare Variant Analysis for Dupuytren Disease in a North American Population., PMID:39570219
LOXL1 promotes gastric cancer progression by β-catenin-cyclinD mediated proliferation., PMID:39547354
Exploring diagnostic biomarkers of type 2 cardio-renal syndrome based on secreted proteins and bioinformatics analysis., PMID:39427047
The epigenetic-modified downregulation of LOXL1 protein mediates EMT in bladder epithelial cells exposed to benzo[a]pyrene and its metabolite BPDE., PMID:39340995
Genetic Foundations of Nellore Traits: A Gene Prioritization and Functional Analyses of Genome-Wide Association Study Results., PMID:39336722
Lysyl Oxidase (LOX) Family Proteins: Key Players in Breast Cancer Occurrence and Progression., PMID:39247609
Matrisome proteomics reveals novel mediators of muscle remodeling with aerobic exercise training., PMID:39220302
Minimal phenotypes in transgenic mice with the human LOXL1/LOXL1-AS1 locus associated with exfoliation glaucoma., PMID:39151208
A comprehensive review on lncRNA LOXL1-AS1: molecular mechanistic pathways of lncRNA LOXL1-AS1 in tumorigenicity of cancer cells., PMID:39136001
Pan-lysyl oxidase inhibition disrupts fibroinflammatory tumor stroma, rendering cholangiocarcinoma susceptible to chemotherapy., PMID:39101793
A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer., PMID:39043186
Downregulation of LOX Overexpression Promotes Retinal Ganglion Cells Survival in an Acute Ocular Hypertension Model., PMID:38979820
Lysyl oxidase-like 1 predicts the prognosis of patients with primary glioblastoma and promotes tumor invasion via EMT pathway., PMID:38978755
In Search of Mouse Models for Exfoliation Syndrome., PMID:38909741
Cell-type specific effects of mineralocorticoid receptor gene expression suggest intercellular communication regulating fibrosis in skeletal muscle disease., PMID:38737833
Potential role of lncRNA LOXL1-AS1 in human cancer development: a narrative review., PMID:38737681
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors., PMID:38693424
LOXL1-AS1 contributes to metastasis in sonic-hedgehog medulloblastoma by promoting cancer stem-like phenotypes., PMID:38689348
Identification of hub genes and key pathways in spinal cord injury via bioinformatics analysis., PMID:38650155
Comprehensive meta-analysis reveals distinct gene expression signatures of MASLD progression., PMID:38565287
Enhanced Optic Nerve Expansion and Altered Ultrastructure of Elastic Fibers Induced by Lysyl Oxidase Inhibition in a Mouse Model of Marfan Syndrome., PMID:38548269
Comprehensive Analysis of the Associations of LOXL1-4 with Prognosis and Immune Infiltration in Breast Cancer., PMID:38518152
Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal., PMID:38466882
Increased LOXL2 expression is related to poor prognosis in lung squamous cell carcinoma., PMID:38410543
Lack of Association between LOXL1 Variants and Pigment Dispersion Syndrome/Pigmentary Glaucoma: A Meta-Analysis., PMID:38397151
Lysyl oxidase like-1 deficiency in optic nerve head astrocytes elicits reactive astrocytosis and alters functional effects of astrocyte derived exosomes., PMID:38331016
LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer., PMID:38267662
LOXL1-AS1 inhibits JAK2 ubiquitination and promotes cholangiocarcinoma progression through JAK2/STAT3 signaling., PMID:38267625
Molecular prognostic of nine parthanatos death-related genes in glioma, particularly in COL8A1 identification., PMID:38225203
Mechanism of lysine oxidase-like 1 promoting synovial inflammation mediating rheumatoid arthritis development., PMID:38217541
Pan-Cancer Analysis of the LOX Family Reveals that LOX Affects Tumor Prognosis by Affecting Immune Infiltration., PMID:38073445
Quercetin antagonized advanced glycated end products induced apoptosis and functional inhibition of fibroblasts from the prolapsed uterosacral ligament., PMID:38044121
Screening of m6A gene-related lncRNAs in colon adenocarcinoma and construction of a prognostic prediction model., PMID:37975370
For research use only. Not for human or drug use.
