Catalog No.
YHG15301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile7-Ser301
Predicted molecular weight
36.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08209
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CAM-PRP catalytic subunit, CNA, Calmodulin-dependent calcineurin A subunit alpha isoform, CALNA, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, PPP3CA
Chronic Exercise Protects Against Cognitive Deficits in an Alzheimer's Disease Model by Enhancing Autophagy and Reducing Mitochondrial Abnormalities., PMID:40448811
Engineered Extracellular Vesicles Loaded with MiR-100-5p Antagonist Selectively Target the Lesioned Region to Promote Recovery from Brain Damage., PMID:40167866
Exploring potential drug targets for SLE through Mendelian randomization and network pharmacology., PMID:39823480
Potential Candidate Genes Associated with Litter Size in Goats: A Review., PMID:39795025
Expanding the clinical spectrum of PPP3CA variants - alternative isoforms matter., PMID:39707491
Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles., PMID:39506111
Defining Alzheimer's Disease through Proteomic CSF Profiling., PMID:39373095
Exploring the therapeutic mechanism of Yuebi decoction on nephrotic syndrome based on network pharmacology and experimental study., PMID:39311772
PPP3CA gene-related developmental and epileptic encephalopathy: Expanding the electro-clinical phenotype., PMID:39305655
Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration., PMID:38654287
Widespread alteration of protein autoinhibition in human cancers., PMID:38366601
Identification of key genes affecting sperm motility in chicken based on whole-transcriptome sequencing., PMID:37856906
Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2+/CaMK2 signaling pathway., PMID:37681454
Evolutionary conserved circular MEF2A RNAs regulate myogenic differentiation and skeletal muscle development., PMID:37676887
A Proteomics Investigation of Cigarette Smoke Exposed Wistar Rats Revealed Improved Anti-Inflammatory Effects of the Cysteamine Nanoemulsions Delivered via Inhalation., PMID:37581495
Embryonic and adult synaptic proteome perturbations after maternal immune activation: Identification of persistent changes relevant for early intervention., PMID:37461513
Neonatal sevoflurane exposure induces long-term changes in dendritic morphology in juvenile rats and mice., PMID:37309741
Elucidation of the Landscape of Alternatively Spliced Genes and Features in the Dorsal Striatum of Aggressive/Aggression-Deprived Mice in the Model of Chronic Social Conflicts., PMID:36980872
CAMTA1-PPP3CA-NFATc4 multi-protein complex mediates the resistance of colorectal cancer to oxaliplatin., PMID:35332122
TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA., PMID:35324524
Intestinal and Mucosal Microbiome Response to Oral Challenge of Enterotoxigenic Escherichia coli in Weaned Pigs., PMID:35215105
Investigation of Copy Number Variations (CNVs) of the Goat PPP3CA Gene and Their Effect on Litter Size and Semen Quality., PMID:35203154
A systems genetics approach delineates the role of Bcl2 in leukemia pathogenesis., PMID:35182904
Programmable siRNA pro-drugs that activate RNAi activity in response to specific cellular RNA biomarkers., PMID:35116191
Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease., PMID:35058554
CD8+ cell somatic mutations in multiple sclerosis patients and controls-Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies., PMID:34874980
Identification of Key Immune-Related Genes in the Progression of Septic Shock., PMID:34804111
MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4'-methylene diphenyl diisocyanate exposed macrophages., PMID:34775880
Calcineurin regulates the stability and activity of estrogen receptor α., PMID:34711683
Full-coverage regulations of autophagy by ROS: from induction to maturation., PMID:34662529
Identification of calcineurin as a predictor of oocyte quality and fertilization competence based on microarray data., PMID:34461466
Impact of severe hypoglycemia on the heat shock and related protein response., PMID:34426634
Tranilast, a Transient Receptor Potential Vanilloid 2 Channel (TRPV2) Inhibitor Attenuates Amyloid β-Induced Cognitive Impairment: Possible Mechanisms., PMID:34231190
npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease., PMID:33986646
PPP3CA truncating variants clustered in the regulatory domain cause early-onset refractory epilepsy., PMID:33963760
Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner., PMID:33885249
Deletion mutation within the goat PPP3CA gene identified by GWAS significantly affects litter size., PMID:33883061
Dysfunction of the Klotho-miR-30s/TRPC6 axis confers podocyte injury., PMID:33862465
Coxsackievirus B3 targets TFEB to disrupt lysosomal function., PMID:33691586
Elucidation of the Mechanisms and Molecular Targets of Shuanglian Decoction for the Treatment of Hepatocellular Carcinoma Based on Network Pharmacology., PMID:33458543
The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer., PMID:33270085
Neuroprotective Effect of 2-Aminoethoxydiphenyl Borate (2-APB) in Amyloid β-Induced Memory Dysfunction: A Mechanistic Study., PMID:33219878
Maxacalcitol (22-Oxacalcitriol (OCT)) Retards Progression of Left Ventricular Hypertrophy with Renal Dysfunction Through Inhibition of Calcineurin-NFAT Activity., PMID:33206298
[PPP3CA silence regulates MET process, cell apoptosis, proliferation and migration in metanephric mesenchyme cells]., PMID:33169579
Calcineurin., PMID:32859215
A novel immune checkpoint-related seven-gene signature for predicting prognosis and immunotherapy response in melanoma., PMID:32731180
Clinical and Genetic Study on a Chinese Patient with Infantile Onset Epileptic Encephalopathy carrying a PPP3CA Null Variant: a case report., PMID:32593294
Genome-wide association analysis reveals the genetic locus for high reproduction trait in Chinese Arbas Cashmere goat., PMID:32506265
Pharmacological Inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study., PMID:32294037
Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration., PMID:32209064
For research use only. Not for human or drug use.
