Catalog No.
YHG14101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu126-Leu385
Predicted molecular weight
32.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q07912
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ACK-1, ACK1, TNK2, Activated CDC42 kinase 1, Tyrosine kinase non-receptor protein 2
Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer., PMID:40419081
ACK1/TNK2 kinase: molecular mechanisms and emerging cancer therapeutics., PMID:39721828
TNK2 Inhibitor (R)-9bMS Causes Polyploidization Through Mitotic Failure by Targeting Aurora B., PMID:39639371
Chimeric SFT2D2-TBX19 Promotes Prostate Cancer Progression by Encoding TBX19-202 Protein and Stabilizing Mitochondrial ATP Synthase through ATP5F1A Phosphorylation., PMID:39540264
SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis., PMID:38965223
ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway., PMID:38650011
Epigenetic underpinnings of tumor-immune dynamics in prostate cancer immune suppression., PMID:38341319
Exome-Wide Sequencing Study Identified Genetic Variants Associated With Sarcopenic Obesity., PMID:38267387
Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor., PMID:37330596
Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer., PMID:37296155
ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer., PMID:37194323
Host factor TNK2 is required for influenza virus infection., PMID:37133719
Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1., PMID:36980241
Co-targeting of ACK1 and KIT triggers additive anti-proliferative and -migration effects in imatinib-resistant gastrointestinal stromal tumors., PMID:36921738
Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure., PMID:36869404
(R)-9bMS Inhibited the Protein Synthesis and Autophagy of Triple Negative Breast Cancer Cells via Regulating miR-4660/mTOR Axis., PMID:36861798
Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk., PMID:36854171
Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models., PMID:36745808
Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance., PMID:36376335
Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region., PMID:36178070
ELK1-Induced upregulation of long non-coding TNK2-AS1 promotes the progression of acute myeloid leukemia by EZH2-mediated epigenetic silencing of CELF2., PMID:35941836
TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability., PMID:35895804
ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics., PMID:35862252
Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting., PMID:35704598
Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation., PMID:35635929
Chemical Reactivity and Optical and Pharmacokinetics Studies of 14 Multikinase Inhibitors and Their Docking Interactions Toward ACK1 for Precision Oncology., PMID:35494626
Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK., PMID:35429500
Tankyrase Regulates Neurite Outgrowth through Poly(ADP-ribosyl)ation-Dependent Activation of β-Catenin Signaling., PMID:35269974
Identification of an ACK1/TNK2-based prognostic signature for colon cancer to predict survival and inflammatory landscapes., PMID:35057760
Free Fatty Acid Species Differentially Modulate the Inflammatory Gene Response in Primary Human Skeletal Myoblasts., PMID:34943232
Loss of Long Noncoding RNA NXTAR in Prostate Cancer Augments Androgen Receptor Expression and Enzalutamide Resistance., PMID:34740892
Small Molecules Targeting Activated Cdc42-Associated Kinase 1 (ACK1/TNK2) for the Treatment of Cancers., PMID:34735773
Long non-coding RNA TNK2 AS1/microRNA-125a-5p axis promotes tumor growth and modulated phosphatidylinositol 3 kinase/AKT pathway., PMID:34494305
Proximity-Dependent Biotinylation to Elucidate the Interactome of TNK2 Nonreceptor Tyrosine Kinase., PMID:34428048
Stable and EGF-Induced Temporal Interactome Profiling of CBL and CBLB Highlights Their Signaling Complex Diversity., PMID:34134489
ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation., PMID:33730447
Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer., PMID:33495411
TNK2 promoted esophageal cancer progression via activating egfr-akt signaling., PMID:33484472
Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases., PMID:33213062
TNK2-AS1 upregulated by YY1 boosts the course of osteosarcoma through targeting miR-4319/WDR1., PMID:33164271
Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition., PMID:33159968
Inhibition of ACK1 delays and overcomes acquired resistance of EGFR mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib., PMID:33049499
Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation., PMID:32958691
Discovery of a series of benzopyrimidodiazepinone TNK2 inhibitors via scaffold morphing., PMID:32739400
Alterations in Tight- and Adherens-Junction Proteins Related to Glaucoma Mimicked in the Organotypically Cultivated Mouse Retina Under Elevated Pressure., PMID:32207812
Targeted inhibition of ACK1 can inhibit the proliferation of hepatocellular carcinoma cells through the PTEN/AKT/mTOR pathway., PMID:32162707
The two splice variant forms of Cdc42 exert distinct and essential functions in neurogenesis., PMID:32071086
Variant analysis of prostate cancer in Japanese patients and a new attempt to predict related biological pathways., PMID:32020225
Benzopyrimidodiazepinone inhibitors of TNK2., PMID:31928839
The non-receptor tyrosine kinase ACK: regulatory mechanisms, signalling pathways and opportunities for attACKing cancer., PMID:31845724
For research use only. Not for human or drug use.
