Catalog No.
YHG13701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Val254
Predicted molecular weight
31.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q07866
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Kinesin light chain 1, KNS2, KLC, KLC1, KLC 1
Proteomic insights into COPD pathogenesis and therapeutic targets: a causal analysis of circulating proteins., PMID:40421300
Kinesin light chain 1 (KLC1) interacts with NS1 and is a susceptibility factor for dengue virus infection in mosquito cells., PMID:40166163
Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome-Wide Mendelian Randomization and Colocalization Analysis., PMID:40026415
Heterogeneous model for superdiffusive movement of dense core vesicles in C. elegans., PMID:40016327
Discovering genetically-supported drug targets for multisite chronic pain through multi-omics Mendelian randomization and single-cell RNA-sequencing., PMID:39993665
KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease., PMID:39829171
The role of kinesin-1 in neuronal dense core vesicle transport, locomotion and lifespan regulation in C. elegans., PMID:39171448
Quantitative proteomics analysis reveals possible anticancer mechanisms of 5'-deoxy-5'-methylthioadenosine in cholangiocarcinoma cells., PMID:38923999
Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2., PMID:38830696
Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing., PMID:38768546
Loss of EIF4G2 mediates aggressiveness in distinct human endometrial cancer subpopulations with poor survival outcome in patients., PMID:38388710
Plasma Proteome-Wide Mendelian Randomization Analysis Reveals Biomarkers and Therapeutic Targets for Different Stages of COVID-19., PMID:40303168
Kinesin light chain 1 stabilizes insulin receptor substrate 1 to regulate the IGF-1-AKT signaling pathway during myoblast differentiation., PMID:38300173
KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway., PMID:38201436
Autoinhibited kinesin-1 adopts a hierarchical folding pattern., PMID:37910016
Autoinhibited kinesin-1 adopts a hierarchical folding pattern., PMID:36747757
ALK-rearranged Mesenchymal Neoplasms: A Report of 9 cases Further Expanding the Clinicopathologic Spectrum of Emerging Kinase Fusion Positive Group of Tumors., PMID:36125853
Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy., PMID:36010968
Variants in PRKCE and KLC1, Potential Regulators of Type I Psoriasis., PMID:35800456
Histologic characterization of paediatric mesenchymal neoplasms treated with kinase-targeted therapy., PMID:35543076
CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons., PMID:34685760
Meta-Analyses of Multiple Gene Expression Profiles to Screen Hub Genes Related to Osteoarthritis., PMID:34340232
Chronic intermittent hypoxia aggravates skeletal muscle aging by down-regulating Klc1/grx1 expression via Wnt/β-catenin pathway., PMID:34218156
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport., PMID:33691783
BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation., PMID:33629936
Tumor Mutational Burden Is Polygenic and Genetically Associated with Complex Traits and Diseases., PMID:33419773
Gene expression in the striatum of cynomolgus monkeys after chronic administration of cocaine and heroin., PMID:33404192
Metaxins are core components of mitochondrial transport adaptor complexes., PMID:33397950
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival., PMID:33284322
Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance., PMID:32265198
Systems Genetics of Optic Nerve Axon Necrosis During Glaucoma., PMID:32174956
Profiling haplotype specific CpG and CpH methylation within a schizophrenia GWAS locus on chromosome 14 in schizophrenia and healthy subjects., PMID:32170143
Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle., PMID:32042098
Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein., PMID:31806024
Effect of Fabomotizole on Brain Gene Expression in MR Rats in the Open Field Test., PMID:31768849
Serial liquid biopsies for detection of treatment failure and profiling of resistance mechanisms in KLC1-ALK-rearranged lung cancer., PMID:31753813
Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases., PMID:31690781
A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis., PMID:31204277
LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains., PMID:31068217
Leveraging brain cortex-derived molecular data to elucidate epigenetic and transcriptomic drivers of complex traits and disease., PMID:30820025
DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle., PMID:30707251
Identification of a novel KLC1-ROS1 fusion in a case of pediatric low-grade localized glioma., PMID:30350109
Kinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway?, PMID:30342167
Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors., PMID:30320553
A Case of Primary Pulmonary Combined Small Cell Carcinoma With Adenocarcinoma Harboring the Same KLC1-ALK Fusion in Both Histologic Components., PMID:30244852
Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons., PMID:30068641
Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1)., PMID:30026235
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies., PMID:29991596
Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non-Small Cell Lung Cancer., PMID:29599410
ALK-rearrangement in non-small-cell lung cancer (NSCLC)., PMID:29488330
For research use only. Not for human or drug use.
