Catalog No.
YHG13301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys233
Predicted molecular weight
28.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q07817
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BCL2L, Bcl-2-like protein 1, Apoptosis regulator Bcl-X, BCL2L1, Bcl2-L-1, BCLX
Interaction between NF-κB and PLAC8 impairs autophagy providing a survival advantage to prostate cells transformed by cadmium., PMID:40512859
The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl-xL or Mcl-1 in ovarian cancer., PMID:40483575
Mast cell tryptase-PAR2 axis promotes ovarian fibrosis through RNF152-mediated stabilization of Bcl-xL., PMID:40474218
Grafted Coiled-Coil Peptides as Multivalent Scaffolds for Protein Recognition., PMID:40468782
Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors., PMID:40442785
BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress., PMID:40436896
20(S)-protopanaxadiol inhibits proliferation and induces apoptosis of acute myeloid leukemia cells via targeting Bcl-XL and MCL-1., PMID:40400713
Dimethyl fumarate abrogates hepatocellular carcinoma growth by inhibiting Nrf2/Bcl-xL axis and enhances sorafenib's efficacy., PMID:40369009
Identification of Hub Genes and Key Pathways Associated with Sepsis Progression Using Weighted Gene Co-Expression Network Analysis and Machine Learning., PMID:40362669
[Role of miR-140-5p/BCL2L1 in apoptosis and autophagy of HFOB1.19 and effect of Bushen Jianpi Huoxue Decoction]., PMID:40350835
Neodymium nitrate promotes the apoptosis of mouse liver cells via Bcl2l1/Caspase 3 pathway., PMID:40331883
Mechanism of Ershen Zhenwu Decoction in ameliorating chronic heart failure via JNK/MAPK-regulated apoptosis: insights from network pharmacology and experimental validation., PMID:40329967
LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers., PMID:40316540
Utilizing bioinformatics to identify biomarkers and analyze their expression in relation to immune cell ratios in femoral head necrosis., PMID:40308566
Albumin nanocomplex of BCL-2/xL inhibitor reduced platelet toxicity and improved anticancer efficacy in myeloproliferative neoplasm and lymphoma., PMID:40306157
Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration., PMID:40268279
Bcl-xL is important for the antiapoptotic activity of Gfi1 and is upregulated by Gfi1 through hemgn., PMID:40262274
Discovery of XZ338, a highly potent BCL-XL degrader., PMID:40239483
Comparison of BH3-dependent and BH3-independent membrane interactions of pro-apoptotic factor BAX., PMID:40181538
A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients., PMID:40141414
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy., PMID:40113751
Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin., PMID:40111633
Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice., PMID:40106552
Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer., PMID:40075071
c-Jun regulates postpartum β-cell apoptosis and survival downstream of prolactin signaling., PMID:40060458
Oncogenic and microenvironmental signals drive cell type specific apoptosis resistance in juvenile myelomonocytic leukemia., PMID:40057493
Protocatechuic acid attenuates isoproterenol-induced heart failure by modulating cardiac oxidative stress, LDL-R/SREBP-2/PPAR-α, and Bax/Bcl-2 /Bcl-xL/Cyt.c/ Caspase - 9 and Caspase - 3 pathways., PMID:40057156
A glycoprotein VI signaling defect in newly formed platelets generated in stress thrombopoiesis., PMID:40056985
Multi-omics study on autophagic dysfunction molecular network in the pathogenesis of rheumatoid arthritis., PMID:40045304
NOTCH1 dimeric signaling is essential for T-cell leukemogenesis and leukemia maintenance., PMID:40009499
Blockade of the STAT3/BCL-xL Axis Leads to the Cytotoxic and Cisplatin-Sensitizing Effects of Fucoxanthin, a Marine-Derived Carotenoid, on Human Bladder Urothelial Carcinoma Cells., PMID:39997178
Collaborative orchestration of BH3-only proteins governs Bak/Bax-dependent hepatocyte apoptosis under antiapoptotic protein-deficiency in mice., PMID:39994353
Gain of 20q11.21 in human pluripotent stem cells enhances differentiation to retinal pigment epithelium., PMID:39985055
Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors., PMID:39966387
Antitumor Activity of Warbugia ugandensis: Methanolic Extracts and Gene Regulation in Colorectal Cancer., PMID:39940328
Design and synthesis of novel sulfur-substituted triptolide with the ability to induce autophagy through inhibition of SRSF1 expression., PMID:39908790
BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation-Induced Apoptosis., PMID:39898973
Bruton's tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax., PMID:39894894
Osalmid sensitizes clear cell renal cell carcinoma to navitoclax through a STAT3/BCL-XL pathway., PMID:39894195
A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice., PMID:39890936
Camptothecin Triggers Apoptosis in Human and Mouse Drug-resistant Glioblastoma Cells via ROS-mediated Activation of the p53-p21-CD1/CDK2-E2F1-Bcl-xL Signaling Axis., PMID:39890198
Doxorubicin-induced phosphorylation of lamin A/C enhances DNMT1 and activates cardiomyocyte death via suppressing GATA-4 and Bcl-xL in rat heart., PMID:39864225
Revealing the therapeutic targets, mechanisms, and heterogeneity of Huatan Jieyu Granules for Parkinson's disease through single-cell sequencing., PMID:39864142
Study on the In Vitro and In Vivo Antioxidant Activity and Potential Mechanism of Polygonum viviparum L., PMID:39857375
Huaier inhibits the proliferation and migration of gastrointestinal stromal tumors by regulating the JAK2 / STAT3 signaling pathway., PMID:39848416
Multidimensional, integrative profiling identifies BCL2L1 methylation as a predictor of MCL1 dependency in pediatric malignancies., PMID:39846250
Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation., PMID:39839500
Sinensetin attenuates LPS-induced acute pulmonary inflammation in mice and RAW264.7 cells by modulating NF-κB p65-mediated immune resistance and STAT3-mediated tissue resilience., PMID:39827664
Exploring the therapeutic potential of Emblica officinalis natural compounds against hepatocellular carcinoma (HCC): a computational approach., PMID:39790561
Succinate Regulates Endothelial Mitochondrial Function and Barrier Integrity., PMID:39765906
For research use only. Not for human or drug use.
