Catalog No.
YHG10301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly294
Predicted molecular weight
36.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q06787
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fragile X mental retardation protein 1, Synaptic functional regulator FMR1, FMR1, Protein FMR-1, FMRP
Interactome of FMRP-N-tat therapeutic unveils key interactions for cellular function in Fragile X neurons., PMID:40480633
A Transcriptomic Dataset of Embryonic Murine Telencephalon of Fmr1-Deficient Mice., PMID:40456813
Modelling fragile X-associated neuropsychiatric disorders in young inducible 90CGG premutation mice., PMID:40455869
Prenatal Exposure to Lipopolysaccharide or Valproate Leads to Abnormal Accumulation of the NMDA Receptor Agonist D-Aspartate in the Adolescent Rat Brain., PMID:40437860
Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators., PMID:40435242
A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism., PMID:40382316
Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions., PMID:40377206
Involvement of the Cerebellar Peduncles in FMR1 Premutation Carriers: A Pictorial Review of Their Anatomy, Imaging, and Pathology., PMID:40362640
Protein-truncating variants and deletions of SHANK2 are associated with autism spectrum disorder and other neurodevelopmental concerns., PMID:40307697
Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early-Postnatal-Stage., PMID:40305761
From Discovery to Innovative Translational Approaches in 80 Years of Fragile X Syndrome Research., PMID:40299377
MSH2 is not required for either maintenance of DNA methylation or repeat contraction at the FMR1 locus in fragile X syndrome or the FXN locus in Friedreich's ataxia., PMID:40296143
Syngap+/- CA1 Pyramidal Neurons Exhibit Upregulated Translation of Long MRNAs Associated with LTP., PMID:40295099
Identification of Common miRNAs Differentially Expressed in Periodontitis and Pancreatic Cancer., PMID:40294979
Transcriptomic profiling of unmethylated full mutation carriers implicates TET3 in FMR1 CGG repeat expansion methylation dynamics in fragile X syndrome., PMID:40287634
Olfactory dysfunction and altered cortical excitability in the mouse model of Fragile X Syndrome., PMID:40275427
CircRNA hsa_ circ_0009022 inhibits colorectal cancer progression by sponging miR-576-5p and complexing with FMRP., PMID:40262487
Higher hyperpolarization-activated current in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of fragile X mice., PMID:40247608
Beyond Repetition: The Role of Gray Zone Alleles in the Upregulation of FMR1-Binding miR-323a-3p and the Modification of BMP/SMAD-Pathway Gene Expression in Human Granulosa Cells., PMID:40244008
In Utero Alcohol and Unsuitable Home Environmental Exposure Combined with FMR1 Full Mutation Allele Cause Severe Fragile X Syndrome Phenotypes., PMID:40243429
Nanopore Long-Read Sequencing as a First-Tier Diagnostic Test to Detect Repeat Expansions in Neurological Disorders., PMID:40243408
Essential lipids enrich membrane-associated condensates to rescue synaptic morpho-functional deficits in a mouse model of autism., PMID:40232934
ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulation., PMID:40220918
Dual Diagnosis of Fragile X Syndrome and DEPDC5-Related Disorder Emphasizes DEPDC5's Role Beyond Familial Epilepsy: A Case Report and Literature Review., PMID:40206130
Role of fragile sites FATS and FMR1 in tumor progression and their potential clinical significance., PMID:40202510
Children With Fragile X Syndrome Display a Switch Towards Fast Fibres in Their Recruitment Strategy During Gait., PMID:40195793
Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice., PMID:40190341
Autistic-like behaviors and impaired chronic inflammatory pain in primary nociceptive neuron-specific deletion of Mecp2 or Fmr1 knockout male mice., PMID:40174753
FMRP Controls Neuronal Architecture and Synaptic Content of NMDA Receptors in Cultured Hippocampal Neurons., PMID:40172581
Sustained Epigenetic Reactivation in Fragile X Neurons with an RNA-Binding Small Molecule., PMID:40149430
Premutation Females with preFXTAS., PMID:40141467
Tissue-Specific Effects of the DNA Helicase FANCJ/BRIP1/BACH1 on Repeat Expansion in a Mouse Model of the Fragile X-Related Disorders., PMID:40141297
Therapeutic Effects of Pharmacological Modulation of Serotonin Brain System in Human Patients and Animal Models of Fragile X Syndrome., PMID:40141138
Prosodic Differences in Women with the FMR1 Premutation: Subtle Expression of Autism-Related Phenotypes Through Speech., PMID:40141125
The prognostic significance of FMR1 expression and its immunomodulatory implications in esophageal carcinoma., PMID:40134827
FDX1 overexpression inhibits the growth and metastasis of clear cell renal cell carcinoma by upregulating FMR1 expression., PMID:40118855
Reduced Respiratory Sinus Arrhythmia in Infants with the FMR1 Premutation., PMID:40076819
Brain network alterations in fragile X syndrome., PMID:40074163
Whole genome transcriptomic profiling reveals distinct sex-specific responses to heat stroke., PMID:40066897
Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice., PMID:40055803
Perirhinal cortex abnormalities impair hippocampal plasticity and learning in Scn2a, Fmr1, and Cdkl5 autism mouse models., PMID:40053578
Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome., PMID:40032522
Systematic Review: Fragile X Syndrome Across the Lifespan with a Focus on Genetics, Neurodevelopmental, Behavioral and Psychiatric Associations., PMID:40004478
Nigrostriatal Degeneration Underpins Sensorimotor Dysfunction in an Inducible Mouse Model of Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS)., PMID:40003975
Upregulation of FMRP Is Involved in Neuropathic Pain by Regulating GluN2B Activation in Rat Spinal Cord., PMID:39989404
Non-ionotropic signaling through the NMDA receptor GluN2B carboxy-terminal domain drives dendritic spine plasticity and reverses fragile X phenotypes., PMID:39983718
Fmr1 KO causes delayed rebound spike timing in mediodorsal thalamocortical neurons through regulation of HCN channel activity., PMID:39975001
Differential effects of sound repetition rate on auditory cortex development and behavior in fragile X syndrome mouse model., PMID:39961384
The Clinical and Molecular Spectrum of Patients With X-Linked Intellectual Disability and Novel Variations in Different Genes., PMID:39951932
High-Sensitivity Fluorescence-Based Detection of Reverse Transcriptase Read-Through of GC-Rich Short Tandem Repeat RNA., PMID:39945490
For research use only. Not for human or drug use.
