Catalog No.
YHG09801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val174-Asp339
Predicted molecular weight
20.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q06609
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HsRAD51, RAD51A, RECA, hRAD51, RAD51, RAD51 homolog A, DNA repair protein RAD51 homolog 1
The prognostic and predictive value of homologous recombination deficiency in gastrointestinal cancer., PMID:40515474
TTI1 contributes to radioresistance by activating ATM pathway in rectal cancer., PMID:40514657
miR-24-2 targets Akt and inhibits cell survival, EMT, and tumour growth in triple-negative breast cancer., PMID:40513147
RNA transcripts regulate G-quadruplex landscapes through G-loop formation., PMID:40504899
Polystyrene nanoplastics induced transgenerational reproductive toxicity in Caenorhabditis elegans through enhanced DNA damage accompanied by DNA repair inhibition., PMID:40499351
FTO inhibition enhances the therapeutic index of radiation therapy in head and neck cancer., PMID:40485587
New twist on BRCA1-mediated DNA recombination repair and tumor suppression., PMID:40480845
Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51., PMID:40480227
Dynamics of chromatin factors RSF1, CENPS and CENPX at DNA damage sites., PMID:40450933
The Slx4-Rad1-Rad10 nuclease differentially regulates deletions and duplications induced by a replication fork barrier., PMID:40446207
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability., PMID:40441151
5'UTR gene regions in germline DNA sequencing panels: lessons from the analysis of breast and ovarian cancer patients of Tatar and Bashkir ethnic origin., PMID:40419811
[Association analysis on BRCA gene functional domain mutations and prognosis in patients with ovarian epithelial carcinoma and fallopian tube carcinoma]., PMID:40419351
MePCE promotes homologous recombination through coordinating R-loop resolution at DNA double-stranded breaks., PMID:40411785
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma., PMID:40393983
Acetyl alkannin, a Shikonin monomer, inhibits the ATM/DDR pathway by targeting ATM and sensitizes cisplatin in solid tumors., PMID:40389196
Preliminary study of apatinib combined with fluzoparib in the treatment of HRP ovarian cancer via the HR pathway., PMID:40386258
Integrative network and computational toxicology reveal the molecular mechanisms in PFOA-induced spermatogenic disorder., PMID:40367801
Telomere Maintenance Pathways in Lower-Grade Gliomas: Insights from Genetic Subtypes and Telomere Length Dynamics., PMID:40362411
Novel proteolysis-targeting chimera targeting RAD51 for the treatment of triple-negative breast cancer., PMID:40350653
Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation., PMID:40323719
Synergistic enhancement of PARP inhibition via small molecule UNI66-mediated suppression of BRD4-dependent transcription of RAD51 and CtIP., PMID:40308947
High-LET Proton Irradiation Significantly Alters the Clonogenic and Tumorigenic Potential of Human Breast Cancer Cell Lines In Vitro and In Vivo., PMID:40302350
Using a novel panel of drug-resistant triple-negative breast cancer cell lines to identify candidate therapeutic targets and biomarkers., PMID:40300663
Ivosidenib Confers BRCAness Phenotype and Synthetic Lethality to Poly (ADP-Ribose) Polymerase Inhibition in BRCA1/2-Proficient Cancer Cells., PMID:40299557
Nuclear-Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance., PMID:40298908
Toxoplasma gondii RAD51 recombinase is required to overcome DNA replication stress and its inactivation leads to bradyzoite differentiation., PMID:40291705
A GWAS of angiotensin-converting enzyme inhibitor-induced angioedema in a South African population., PMID:40290521
Fluoxetine-Conjugated Platinum(IV) Prodrugs Targeting eEF2K and Conquering Multidrug Resistance against Triple-Negative Breast Cancer., PMID:40265570
Rational Design of UvsX Recombinase Variants for Enhanced Performance in Recombinase Polymerase Amplification Applications., PMID:40261914
A variant in RNF212B may contribute to female infertility and recurrent pregnancy loss., PMID:40259604
2β-methoxy-2-deethoxyphantomolin synergistically enhances epirubicin effect against triple-negative breast cancer via targeted inhibition of AKT and HR pathways., PMID:40253761
Trabectedin Induces Synthetic Lethality via the p53-Dependent Apoptotic Pathway in Ovarian Cancer Cells Without BRCA Mutations When Used in Combination with Niraparib., PMID:40243501
PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: Implications for the interplay between human DNA damage tolerance pathways., PMID:40236028
Evaluating the efficacy of PARP inhibitor in ARID1A-deficient colorectal cancer: A ex vivo study., PMID:40235227
Exploring Rad51 inhibition mechanisms of B02 and IBR2 and identifying prospective drug candidates for Rad51: A computational investigation., PMID:40233679
RAD51 expression and prognostic impact in patients with stomach adenocarcinoma., PMID:40231067
CHK1 inhibition overcomes gemcitabine resistance in non-small cell lung cancer cell A549., PMID:40226818
Epigenetically elevated RAD51AP1 regulates the RAD51-UAF1 complex contributing to temozolomide resistance in EGFRvIII glioblastoma., PMID:40211735
Single-cell RNA sequencing reveals the intra-tumoral heterogeneity and immune microenvironment of small cell carcinoma of the ovary, hypercalcemic type., PMID:40205496
Exosomal miR-92b-5p regulates N4BP1 to enhance PTEN mono-ubiquitination in doxorubicin-resistant AML., PMID:40201312
Structural basis for Rad54- and Hed1-mediated regulation of Rad51 during the transition from mitotic to meiotic recombination., PMID:40196570
Chemoproteomic analysis reveals RECQL4 as a mediator of nitroalkene-dependent double-strand break repair inhibition in cancer., PMID:40196015
Analysis of rad-51 separation of function allele suggests divergence of the synthesis-dependent strand annealing and double Holliday junction pathways prior to RAD-51 filament disassembly., PMID:40192500
The m6A RNA demethylase FTO promotes radioresistance and stemness maintenance of glioma stem cells., PMID:40185350
Benefit from maintenance with PARP inhibitor in newly diagnosed ovarian cancer according to BRCA1/2 mutation type and site: a multicenter real-world study., PMID:40174507
A Rfa1-MN-based system reveals new factors involved in the rescue of broken replication forks., PMID:40168399
Pimitespib, an HSP90 Inhibitor, Enhances the Efficacy of PARP Inhibitors in PARP Inhibitor-Insensitive Breast Cancer Cells., PMID:40167031
ATP hydrolysis-driven structural transitions within the S. cerevisiae Rad51 and Dmc1 nucleoprotein filaments., PMID:40166259
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms., PMID:40158218
For research use only. Not for human or drug use.
