Catalog No.
YHG09201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly210
Predicted molecular weight
25.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q06481
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
APPH, APLP-2, CDEBP, Amyloid protein homolog, CDEI box-binding protein, APLP2, APPL2, Amyloid-like protein 2
Immunohistochemical profile of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) versus other thyroid follicular lesions., PMID:40420140
Amyloid precursor-like protein 2 expression in macrophages: differentiation and M1/M2 macrophage dynamics., PMID:40265027
Diabetes affects AD through plasma Aβ40: A Mendelian randomization study., PMID:40233921
Familial Alzheimer's disease mutations in amyloid precursor protein impair calcineurin signaling to NMDA receptors., PMID:39732167
Quercetin ameliorates cognitive deficit, expression of amyloid precursor gene, and pro-inflammatory cytokines in an experimental models of Alzheimer's disease in Wistar rats., PMID:38821324
Fine-Tuning Amyloid Precursor Protein Expression through Nonsense-Mediated mRNA Decay., PMID:38789273
Persistent diazinon induced neurotoxicity: The effect on inhibitory avoidance memory performance, amyloid precursor proteins, and TNF-α levels in the prefrontal cortex of rats., PMID:38472141
VGLUT2 and APP family: unraveling the neurobiochemical mechanisms of neurostimulation therapy to STZ-induced diabetes and neuropathy., PMID:38370359
Single-Cell Transcriptional Response of the Placenta to the Ablation of Caveolin-1: Insights into the Adaptive Regulation of Brain-Placental Axis in Mice., PMID:38334607
Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis., PMID:38148084
Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage., PMID:37844466
APP family member dimeric complexes are formed predominantly in synaptic compartments., PMID:37533067
Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression., PMID:37515494
YWK-II/APLP2 inhibits TGF-β signaling by interfering with the TGFBR2-Hsp90 interaction., PMID:37479189
Comparative binding analysis of WGX50 and Alpha-M with APP family proteins APLP1 and APLP2 using structural-dynamics and free energy calculation approaches., PMID:37199163
Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals., PMID:36765071
APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain., PMID:36691315
TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a proinflammatory phenotype in human monocytes., PMID:36629908
Trio-based exome sequencing broaden the genetic spectrum in keratoconus., PMID:36502923
Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization., PMID:36442651
Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory., PMID:36385765
Presenilin and APP Regulate Synaptic Kainate Receptors., PMID:36288945
Encephalomalacia/gliosis, deep venous thrombosis, and cancer in Arg393His antithrombin Hanoi and the potential impact of the β-amyloid precursor protein (APP) on thrombosis and cancer., PMID:35860682
Immuno-histochemical correlation of fibrosis-related markers with the desmoplastic reaction of the mesentery in small intestine neuroendocrine neoplasms., PMID:35796776
Proteomic analysis of autoimmune retinopathy implicates NrCAM as a potential biomarker., PMID:35529077
Finding New Ways How to Control BACE1., PMID:35305135
Effects of toluidine blue O and methylene blue on growth and viability of pancreatic cancer cells., PMID:35092039
Transcriptome profiling of morphogenetic differences between contour and flight feathers in duck., PMID:35000502
Regulation of gene expression by the APP family in the adult cerebral cortex., PMID:34997052
Potential molecular link between the β-amyloid precursor protein (APP) and hypoxanthine-guanine phosphoribosyltransferase (HGprt) enzyme in Lesch-Nyhan disease and cancer., PMID:34877405
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling., PMID:34526379
Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND., PMID:34476545
APPsα rescues impaired Ca2+ homeostasis in APP- and APLP2-deficient hippocampal neurons., PMID:34172567
Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer., PMID:34066808
Rapid evolution of mammalian APLP1 as a synaptic adhesion molecule., PMID:34050225
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype., PMID:34008862
Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer., PMID:33810510
Relationships between the Bone Expression of Alzheimer's Disease-Related Genes, Bone Remodelling Genes and Cortical Bone Structure in Neck of Femur Fracture., PMID:33398413
APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival., PMID:32891188
APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China., PMID:32716039
Knockdown of circAPLP2 Inhibits Progression of Colorectal Cancer by Regulating miR-485-5p/FOXK1 Axis., PMID:32343603
Amyloid precursor-like protein 2 interacts with claudin-7 and affects ovarian cancer cell survival., PMID:32257370
Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition., PMID:32219307
The amyloid precursor protein affects glyceraldehyde 3-phosphate dehydrogenase levels, organelle localisation and thermal stability., PMID:32152789
Quantitative proteomic analysis reveals that Luks-PV exerts antitumor activity by regulating the key proteins and metabolic pathways in HepG2 cells., PMID:31789624
Withaferin A inhibits adipogenesis in 3T3-F442A cell line, improves insulin sensitivity and promotes weight loss in high fat diet-induced obese mice., PMID:31226166
Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways., PMID:31063592
Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells., PMID:30810435
An Integrative Data Mining and Omics-Based Translational Model for the Identification and Validation of Oncogenic Biomarkers of Pancreatic Cancer., PMID:30700038
Identification of Blood Biomarkers for Alzheimer's Disease Through Computational Prediction and Experimental Validation., PMID:30671019
For research use only. Not for human or drug use.
