Catalog No.
YHG05901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu119-Arg230
Predicted molecular weight
15.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q05901
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neuronal acetylcholine receptor subunit beta-3, CHRNB3
Upregulation of CXCL1 and LY9 contributes to BRCAness in ovarian cancer and mediates response to PARPi and immune checkpoint blockade., PMID:35618786
Identification of Characteristic Genes in Whole Blood of Intervertebral Disc Degeneration Patients by Weighted Gene Coexpression Network Analysis (WGCNA)., PMID:35069789
NMDA Receptor Expression by Retinal Ganglion Cells Is Not Required for Retinofugal Map Formation nor Eye-Specific Segregation in the Mouse., PMID:34193509
Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε., PMID:32776643
Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome., PMID:31120189
A Chrnb3-Cre BAC transgenic mouse line for manipulation of gene expression in retinal ganglion cells., PMID:31087513
Genetic variants in nicotinic receptors and smoking cessation in Parkinson's disease., PMID:30777653
The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers., PMID:29751336
Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women., PMID:29621993
Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population., PMID:28851948
Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior., PMID:28420875
Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence., PMID:27827986
Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors., PMID:27645992
Classification Tree Analysis as a Method for Uncovering Relations Between CHRNA5A3B4 and CHRNB3A6 in Predicting Smoking Progression in Adolescent Smokers., PMID:27613882
Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research., PMID:27327258
Genetic variants associated with physical and mental characteristics of the elite athletes in the Polish population., PMID:27140937
Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence., PMID:27085880
Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer., PMID:27050379
Gene variance in the nicotinic receptor cluster (CHRNA5-CHRNA3-CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers., PMID:26689306
Search for Rare Copy-Number Variants in Congenital Heart Defects Identifies Novel Candidate Genes and a Potential Role for FOXC1 in Patients With Coarctation of the Aorta., PMID:26643481
The β3 subunit of the nicotinic acetylcholine receptor: Modulation of gene expression and nicotine consumption., PMID:26318101
Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder., PMID:26184988
A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations., PMID:25823894
Are genetic variants for tobacco smoking associated with cannabis involvement?, PMID:25770649
Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma., PMID:25233467
Efficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunits., PMID:25068303
Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior., PMID:24804708
Combined effect between CHRNB3-CHRNA6 region gene variant (rs6474412) and smoking in psoriasis vulgaris severity., PMID:24792900
CHRNB3 c.-57A>G functional promoter change affects Parkinson's disease and smoking., PMID:24731518
Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy., PMID:24675634
Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans., PMID:24401102
The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke., PMID:24119711
Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence., PMID:24057674
Nicotinic Receptor Mutation in a Mildly Dysmorphic Girl with Duane Retraction Syndrome., PMID:24001015
Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood., PMID:23899432
Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations., PMID:23319001
The α6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation., PMID:22572056
CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results., PMID:22524403
Modulation of gain-of-function α6*-nicotinic acetylcholine receptor by β3 subunits., PMID:22315221
Association study of 45 candidate genes in nicotine dependence in Han Chinese., PMID:22309839
Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence., PMID:22042774
[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population]., PMID:21831805
Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study., PMID:21606657
Associations of nicotine intake measures with CHRN genes in Finnish smokers., PMID:21498873
Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene., PMID:21191315
Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers., PMID:20923852
CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences., PMID:20854418
Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence., PMID:20840187
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans., PMID:20584212
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior., PMID:20418888
For research use only. Not for human or drug use.
