Catalog No.
YHG05801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile358-His583
Predicted molecular weight
27.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q05823
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ribonuclease L, Ribonuclease 4, 2-5A-dependent RNase, 2-5A-dependent ribonuclease, RNS4, RNASEL, RNase L
Structural basis for OAS2 regulation and its antiviral function., PMID:40412389
Effective recognition of double-stranded RNA does not require activation of cellular inflammation., PMID:40203104
OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity., PMID:40010341
Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion., PMID:39975384
Casein Glycomacropeptide Regulates Gene Expression in Intestinal Epithelial Cells: Effect of Simulated Gastrointestinal Digestion and Peptide Microencapsulation., PMID:39921639
RNase L represses hair follicle regeneration through altered innate immune signaling., PMID:39903537
Sus scrofa RNase L inhibits PRRSV replication by activation of type I IFN signaling pathway and apoptosis., PMID:39827524
DHX15 and Rig-I Coordinate Apoptosis and Innate Immune Signaling by Antiviral RNase L., PMID:39772220
The Unusual Role of Ribonuclease L in Innate Immunity., PMID:39727035
Protein family FAM241 in human and mouse., PMID:39715844
Modulation of the Gut-Lung Axis by Water Kefir and Kefiran and Their Impact on Toll-like Receptor 3-Mediated Respiratory Immunity., PMID:39595633
Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C)., PMID:39576310
A CRISPR-Cas9 knockout screening identifies IRF2 as a key driver of OAS3/RNase L-mediated RNA decay during viral infection., PMID:39475651
Regulation and Dynamics of IFN-β Expression Revealed with a Knockin Reporter Mouse., PMID:39475224
Whole-transcriptome analyses of ovine lung microvascular endothelial cells infected with bluetongue virus., PMID:39334220
Downregulation of the m6A reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members., PMID:39303913
Identification of ribosome biogenesis genes and subgroups in ischaemic stroke., PMID:39290696
Molecular Bases and Specificity behind the Activation of the Immune System OAS/RNAse L Pathway by Viral RNA., PMID:39205220
RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway., PMID:39112803
Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras., PMID:39047145
Human genetic and immunological determinants of SARS-CoV-2 infection and multisystem inflammatory syndrome in children., PMID:39028583
A closer look at mammalian antiviral condensates., PMID:38778761
Condensation of RNase L promotes its rapid activation in response to viral infection in mammalian cells., PMID:38771918
Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L., PMID:38551960
Development of an immune-related diagnostic predictive model for oral lichen planus., PMID:38489725
Recurrent viral capture of cellular phosphodiesterases that antagonize OAS-RNase L., PMID:38277437
Single-cell analysis of RNase L-mediated mRNA decay., PMID:37925178
Antiviral effects of duck type I and type III interferons against Duck Tembusu virus in vitro and in vivo., PMID:37913673
OAS1 suppresses African swine fever virus replication by recruiting TRIM21 to degrade viral major capsid protein., PMID:37815352
RNase L-activating 2'-5' oligoadenylates bind ABCF1, ABCF3 and Decr-1., PMID:37676257
Origin of the OAS-RNase L innate immune pathway before the rise of jawed vertebrates via molecular tinkering., PMID:37487089
Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2., PMID:37432877
Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family., PMID:37209263
Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors., PMID:37201427
The Nucleocapsid Proteins of SARS-CoV-2 and Its Close Relative Bat Coronavirus RaTG13 Are Capable of Inhibiting PKR- and RNase L-Mediated Antiviral Pathways., PMID:37154717
Post-immunobiotics increase resistance to primary respiratory syncytial virus infection and secondary pneumococcal pneumonia., PMID:37128181
The HIV Restriction Factor Profile in the Brain Is Associated with the Clinical Status and Viral Quantities., PMID:36851531
Occludin regulates HIV-1 infection by modulation of the interferon stimulated OAS gene family., PMID:36778388
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children., PMID:36538032
The performance of multi-gene panels for breast/ovarian cancer predisposition., PMID:36521553
Regulation of ribonucleoprotein condensates by RNase L during viral infection., PMID:36479619
Rotavirus NSP1 Subverts the Antiviral Oligoadenylate Synthetase-RNase L Pathway by Inducing RNase L Degradation., PMID:36413023
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus., PMID:36318584
Proposal for the use of an inhalation drug containing 2-5 oligoadenylates for treatment of COVID-19., PMID:36317071
PDE12 in type 1 diabetes., PMID:36307540
Human Melanoma Cells Differentially Express RNASEL/RNase-L and miR-146a-5p under Sex Hormonal Stimulation., PMID:36286041
Modulation of Alveolar Macrophages by Postimmunobiotics: Impact on TLR3-Mediated Antiviral Respiratory Immunity., PMID:36230948
Mature Rotavirus Particles Contain Equivalent Amounts of 7meGpppG-Capped and Noncapped Viral Positive-Sense RNAs., PMID:36000838
Antagonism of Protein Kinase R by Large DNA Viruses., PMID:35890034
A genome-wide screen for resilient responses in growing pigs., PMID:35787790
For research use only. Not for human or drug use.
