Catalog No.
YHG04701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly798-Ala1041
Predicted molecular weight
29.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q05397
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p125FAK, pp125FAK, PPP1R71, Protein-tyrosine kinase 2, FADK 1, FAK1, Focal adhesion kinase 1, FAK, PTK2, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71
HEY1 promotes the development and metastasis of osteosarcoma through CD44/EGFR/FAK pathway., PMID:40531089
Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition., PMID:40506423
A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions., PMID:40500799
A novel galactoglucan from Ganoderma lucidum ameliorates ethanol-induced gastric ulcers by modulating FAK-MAPK signaling pathway., PMID:40399003
Targeting the hydrophobic pockets of FAK/PYK2 FAT domain: a highly effective inhibitory strategy suppressing tumor growth and eliminating metastasis., PMID:40390029
Epstein-Barr virus induces aberrant B cell migration and diapedesis via FAK-dependent chemotaxis pathways., PMID:40389409
Transcriptome analysis reveals key genes and signalling pathways related to residual feed intake in meat-type ducks., PMID:40367888
Ginkgetin inhibits the proliferation and migration of lung cancer cells via FAK/STAT3/AKT pathway., PMID:40366441
Acetazolamide as an aquaporin 1 inhibitor mitigates rheumatoid arthritis by reducing angiogenesis via the modulation of the FAK-PI3K/Akt signaling pathway., PMID:40359885
The potential of MCM8 as a biomarker in esophageal carcinoma: a comprehensive analysis integrating m6a methylation and angiogenesis., PMID:40346692
Melatonin attenuates Helicobacter pylori-mediated cholangiocarcinoma-associated fibroblast activation via modulating integrin/FAK signaling pathway., PMID:40329017
Development of a high-throughput TR-FRET assay to identify inhibitors of the FAK-paxillin protein-protein interaction., PMID:40318755
Yijing Decoction improves premature ovarian failure in rats by activating VEGF/VEGFR-2/FAK pathway., PMID:40287776
Leucine rich repeat containing 15 promotes triple-negative breast cancer proliferation and invasion via the ITGB1/FAK/PI3K signalling pathway., PMID:40281111
Targeting Signaling Excitability in Cervical and Pancreatic Cancer Cells Through Combined Inhibition of FAK and PI3K., PMID:40243705
Spatial regulation of mitochondrial membrane potential by α5β1 integrin engagement in collective cell migration., PMID:40223421
Gene expression profile of anoikis reveals new subtypes of liver cancer and discovery of therapeutic targets and biomarkers., PMID:40223133
FAK regulates trophoblast functions of invasion and proliferation through Rap1 pathway in early-onset preeclampsia., PMID:40220488
Daidzein and puerarin synergistically suppress gastric cancer proliferation via STAT3/FAK pathway Inhibition., PMID:40217305
Loss of ADAMTS5 promotes vascular calcification via versican/integrin β1/FAK signal., PMID:40215897
NELL2, a novel osteoinductive factor, regulates osteoblast differentiation and bone homeostasis through fibronectin 1/integrin-mediated FAK/AKT signaling., PMID:40210857
Si-ITGA6-Loaded Liposomes Inhibit Capsule Fibrosis via the FAK/PI3K/Akt Signaling Pathway in Adhesive Capsulitis of Shoulder., PMID:40207309
Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2-null mice activates p53 tumor suppressor to prevent tumor growth., PMID:40202821
HINT1 aggravates aortic aneurysm by targeting ITGA6/FAK axis in vascular smooth muscle cells., PMID:40198125
Therapeutic potential of GNRHR analogs and SRC/FAK inhibitors to counteract tumor growth and metastasis in breast cancer., PMID:40189112
Discovery and characterization of novel FAK inhibitors for breast cancer therapy via hybrid virtual screening, biological evaluation and molecular dynamics simulations., PMID:40163988
Exploring Thieno/Furo[2,3-b]pyridines as new scaffolds for potential FAK inhibition: Design, synthesis, biological evaluation and in silico studies., PMID:40139117
Transcriptomic and Lipidomic Characteristics of Subcutaneous Fat Deposition in Small-Sized Meat Ducks., PMID:40137123
Conformation-Driven Phase Separation in the Linker Domain of Focal Adhesion Kinases., PMID:40136251
Identifcation of the FGF family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma., PMID:40086631
Nf2-FAK signaling axis is critical for cranial bone ossification and regeneration., PMID:40075076
Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition., PMID:40068589
Irisin decreases follicle development in cattle and inhibits theca cell steroidogenesis through focal adhesion kinase signaling., PMID:40062916
Integrating a multi-omics strategy framework to screen potential targets in cognitive impairment-related epilepsy., PMID:40049431
Prognostic value of serum lipids in newly diagnosed acute promyelocytic leukemia., PMID:40040719
Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer., PMID:40021642
FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma., PMID:40020669
Targeting RECQL4 in hepatocellular carcinoma: from prognosis to therapeutic potential., PMID:40001159
Plasma Exosomal circRNAs as Potential Biomarkers for Patients with Septic Shock-Induced Acute Kidney Injury., PMID:39994492
Single-cell RNA sequencing reveals ECM remodeling-tumor stiffness-FAK as a key driver of vestibular schwannoma progression., PMID:39988022
Hepatic adverse events associated with anaplastic lymphoma kinase tyrosine kinase inhibitors: a disproportionality analysis based on FAERS database and analysis of drug-gene interaction network., PMID:39949054
Discovery of 2,4-diaminopyrimidine derivatives as potent inhibitors of FAK capable of activating the Hippo pathway for the treatment of esophageal squamous cell carcinoma., PMID:39947050
FAK mediates mechanical signaling to maintain epithelial homeostasis through YAP/TAZ-TEADs., PMID:39918604
Endothelial Cell pY397-FAK Expression Predicts the Risk of Breast Cancer Recurrences after Radiotherapy in the SweBCG91-RT Cohort., PMID:39908003
Silencing LINC01547 induces hepatocellular carcinoma cell apoptosis and metastasis inhibition via the ADAR1/FAK and miR-146b-5p/RAC1 axes., PMID:39904859
CircFak promotes mechanical force-induced osteogenesis via FAK/AKT phosphorylation., PMID:39894158
Focal adhesion kinase mediates microvascular leakage and endothelial barrier dysfunction in ischemia-reperfusion injury., PMID:39884384
XOR-Derived ROS in Tie2-Lineage Cells Including Endothelial Cells Promotes Aortic Aneurysm Progression in Marfan Syndrome., PMID:39882602
Joint exploration of network pharmacology and metabolomics on the effects of traditional Chinese medicine compounds in weaned yaks., PMID:39872609
Downregulation of collagen IV deposition and ITGB1-FAK signaling pathway to inhibit adipogenesis: A novel mechanism of swertiamarin in treating type 2 diabetes mellitus., PMID:39832590
For research use only. Not for human or drug use.
