Catalog No.
YHG04001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met291-Leu407
Predicted molecular weight
15.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q05086
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Oncogenic protein-associated protein E6-AP, Ubiquitin-protein ligase E3A, UBE3A, E6AP ubiquitin-protein ligase, HPVE6A, EPVE6AP, HECT-type ubiquitin transferase E3A, E6AP, Human papillomavirus E6-associated protein, Renal carcinoma antigen NY-REN-54
Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids., PMID:40447862
Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome Analysis., PMID:40444580
Novel method for detection of UBE3A protein in CSF from individuals with Angelman syndrome., PMID:40411957
Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome., PMID:40382580
Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model mice., PMID:40310720
Dietary Intake of Octanoic Acid Restores UBE3A Expression and Improves the Behavioral Phenotypes in a Mouse Model of Angelman Syndrome., PMID:40277210
Dynamic shift in localization of UBE3A across developmental stages in an Angelman syndrome mouse model., PMID:40250721
The essential role of E3 ubiquitin ligases in the pathogenesis of neurodevelopmental and psychiatric disorders: Cul3, Cul4, Ube3a, and ZNRF1., PMID:40233431
Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism., PMID:40213945
Localization of human UBE3A isoform 3 is highly sensitive to amino acid substitutions at p.Met21 position., PMID:40211773
Molecular aspects of Angelman Syndrome: Defining the new path forward., PMID:40138703
Age-Related Trajectories of Autistic Traits in Children With Angelman Syndrome., PMID:40116126
The gain-of-function UBE3AQ588E variant causes Angelman-like neurodevelopmental phenotypes in mice., PMID:40097479
YTHDC1 negatively regulates UBE3A to influence RAD51 ubiquitination and inhibit apoptosis in colorectal cancer cells., PMID:40087295
Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration., PMID:40076922
Neonatal/infantile-onset genetic epilepsies: The utility of genetic testing for molecular etiology-specific diagnosis concerning therapeutic implications., PMID:40072314
Rational Design of Stapled Covalent Peptide Modifiers of Oncoprotein E6 from Human Papillomavirus., PMID:40063062
A Perspective on Therapeutic Targeting Against Ubiquitin Ligases to Stabilize Tumor Suppressor Proteins., PMID:40002221
A high sensitivity assay of UBE3A ubiquitin ligase activity., PMID:39933617
E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence., PMID:39919145
UBE3A controls axon initial segment in the cortical pyramidal neurons., PMID:39914145
Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation., PMID:39818213
Optimized isolation of enzymatically active ubiquitin E3 ligase E6AP/UBE3A from mammalian cells., PMID:39798888
Proteomic Profiling of Potential E6AP Substrates via Ubiquitin-based Photo-Crosslinking Assisted Affinity Enrichment., PMID:39797819
DARPin-induced reactivation of p53 in HPV-positive cells., PMID:39789211
Concordance of Whole-Genome Long-Read Sequencing with Standard Clinical Testing for Prader-Willi and Angelman Syndromes., PMID:39756651
Differences in structure, dynamics, and zinc coordination between isoforms of human ubiquitin ligase UBE3A., PMID:39742997
Comparative profiling of white matter development in the human and mouse brain reveals volumetric deficits and delayed myelination in Angelman syndrome., PMID:39726042
Heterozygous UBR5 variants result in a neurodevelopmental syndrome with developmental delay, autism, and intellectual disability., PMID:39721588
STING exerts antiviral innate immune response by activating pentose phosphate pathway., PMID:39695767
CaMKIIα hub ligands are unable to reverse known phenotypes in Angelman syndrome mice., PMID:39668309
Long-read sequencing for detection and subtyping of Prader-Willi and Angelman syndromes., PMID:39537351
[Genetic analysis of a pedigree affected with Intellectual disability due to variants of two different genes]., PMID:39528279
Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model., PMID:39511336
UBE3A: Bridging the gap between neurodevelopment, neural function, and neurodegenerative woes., PMID:39497315
Identification of fibrosis-associated lncRNAs in diabetic cardiomyopathy patients., PMID:39475132
AAV vector-derived elements integrate into Cas9-generated double-strand breaks and disrupt gene transcription., PMID:39367606
[Angelman syndrome: current approach and the future of therapies]., PMID:39331770
Prenatal Exposure to Azadiradione Leads to Developmental Disabilities., PMID:39312066
Multiscale spatio-temporal dynamics of UBE3A gene in brain physiology and neurodevelopmental disorders., PMID:39293689
Crosstalk between ubiquitination and translation in neurodevelopmental disorders., PMID:39286313
Glial expression of Drosophila UBE3A causes spontaneous seizures that can be modulated by 5-HT signaling., PMID:39197537
Angelman syndrome in Poland: current diagnosis and therapy status-the caregiver perspective: a questionnaire study., PMID:39174987
Genotype-phenotype correlation over time in Angelman syndrome: Researching 134 patients., PMID:39169619
Precision Medicine in Angelman Syndrome., PMID:39168152
Neuronal UBE3A substrates hold therapeutic potential for Angelman syndrome., PMID:39126903
A case of an Angelman-syndrome caused by an intragenic duplication of UBE3A uncovered by adaptive nanopore sequencing., PMID:39095842
1H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome., PMID:39049050
Integration of CTCF loops, methylome, and transcriptome in differentiating LUHMES as a model for imprinting dynamics of the 15q11-q13 locus in human neurons., PMID:39045627
For research use only. Not for human or drug use.
