Catalog No.
YHG03901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly258
Predicted molecular weight
32.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q05084
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p69, ICA1, Islet cell autoantigen 1, ICA69, 69 kDa islet cell autoantigen, ICAp69, Islet cell autoantigen p69
Widespread genomic de novo DNA methylation occurs following CD8+ T cell activation and proliferation., PMID:38899429
ICA1 affects APP processing through the PICK1-PKCα signaling pathway., PMID:38884369
Dual inhibition of atypical PKC signaling and PI3K/Akt signaling dysregulates c-Myc to induce apoptosis in clear cell Renal Cell Carcinoma., PMID:38288105
ICA69 regulates activity-dependent synaptic strengthening and learning and memory., PMID:37251649
Bioinformatics Analysis Identifies Key Genes in Recurrent Implantation Failure Based on Immune Infiltration., PMID:36045247
QTL-mapping in the obese Berlin Fat Mouse identifies additional candidate genes for obesity and fatty liver disease., PMID:35729251
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature., PMID:35093322
Different encoding of reward location in dorsal and intermediate hippocampus., PMID:35016008
Polygenetic-Risk Scores Related to Crystallin Metabolism Are Associated with Age-Related Cataract Formation and Interact with Hyperglycemia, Hypertension, Western-Style Diet, and Na Intake., PMID:33213085
Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes., PMID:33035505
Islet-cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfβ signaling in mice., PMID:32531799
Ritanserin blocks CaV1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies., PMID:32132658
Novel SRF-ICA1L Fusions in Cellular Myoid Neoplasms With Potential For Malignant Behavior., PMID:31478943
Genetic Interactions and Molecular Evolution of the Duplicated Genes ICARUS2 and ICARUS1 Help Arabidopsis Plants Adapt to Different Ambient Temperatures., PMID:30992321
Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice., PMID:30699097
Inhibition of atypical protein kinase C‑ι effectively reduces the malignancy of prostate cancer cells by downregulating the NF-κB signaling cascade., PMID:30226591
Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors., PMID:29781749
MC225, a Novel Probe for P-glycoprotein PET Imaging at the Blood-brain Barrier: In Vitro Cardiovascular Safety Evaluation., PMID:28877068
In vitro vascular toxicity of tariquidar, a potential tool for in vivo PET studies., PMID:28746893
Cav1.2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: Electrophysiological, functional, and molecular docking studies., PMID:28583845
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies., PMID:27888581
The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: A modeling investigation., PMID:27765528
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A., PMID:26493241
ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis., PMID:26306493
Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren's syndrome., PMID:26031516
Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at High Temperatures in Arabidopsis thaliana., PMID:25951176
Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw., PMID:25547463
A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice., PMID:25418976
PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites., PMID:25392508
Compromised central tolerance of ICA69 induces multiple organ autoimmunity., PMID:25088457
The interruption of PKC-ι signaling and TRAIL combination therapy against glioblastoma cells., PMID:24965532
Human fibrocytes express multiple antigens associated with autoimmune endocrine diseases., PMID:24517144
C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCα complex and cerebellar plasticity., PMID:24358315
Temporal organization of GABAergic interneurons in the intermediate CA1 hippocampus during network oscillations., PMID:24275828
Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus., PMID:23836780
Neuroendocrinology: regulated secretory cells go to the BAR for a bud., PMID:23797817
A pair of crescent-shaped proteins shape vesicles at the golgi., PMID:23630455
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance., PMID:23630454
PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance., PMID:23630453
Genetic associations to germinal centre formation in primary Sjogren's syndrome., PMID:23606706
Islet autoantigens: structure, function, localization, and regulation., PMID:22908193
Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression., PMID:22447927
Mechanism of osthole inhibition of vascular Ca(v)1.2 current., PMID:22329900
Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population., PMID:22039224
The flavonoid scaffold as a template for the design of modulators of the vascular Ca(v) 1.2 channels., PMID:21557738
Microduplications in an autism multiplex family narrow the region of susceptibility for developmental disorders on 15q24 and implicate 7p21., PMID:21480499
A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma., PMID:21315177
The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes., PMID:21244337
A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles., PMID:20962850
Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes., PMID:20530722
For research use only. Not for human or drug use.
