Catalog No.
YHF98501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu260-Glu426
Predicted molecular weight
21.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q03181
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PPARD, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, NR1C2, NUC1, Peroxisome proliferator-activated receptor delta, PPAR-beta, PPAR-delta, PPARB, NUCI, Peroxisome proliferator-activated receptor beta
Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction after intestinal injury and LPS exposure., PMID:40502773
Transcriptomic Profiling of Hypoxia-Adaptive Responses in Tibetan Goat Fibroblasts., PMID:40427283
Compound 3d Attenuates Metabolic Dysfunction-Associated Steatohepatitis via Peroxisome Proliferator-Activated Receptor Pathway Activation and Inhibition of Inflammatory and Apoptotic Signaling., PMID:40422873
Experimental verification of Myriocin molecular bioactivity in revoking rheumatoid arthritis: New emphasis on S100A1 repression and PPAR-γ activation via non-canonical pathways in the flare-up of cytokines., PMID:40354710
Fatty acid metabolism suppresses neonatal cardiomyocyte proliferation by increasing PDK4 and HMGCS2 expression through PPARδ., PMID:40338840
Competitive Ligand-Induced Recruitment of Coactivators to Specific PPARα/δ/γ Ligand-Binding Domains Revealed by Dual-Emission FRET and X-Ray Diffraction of Cocrystals., PMID:40298866
Alstonia scholaris (L.) R. Br. ameliorated diabetic nephropathy through PPAR-δ pathway., PMID:40294665
PPAR-mediated reduction of lipid accumulation in hepatocytes involves the autophagy-lysosome-mitochondrion axis., PMID:40289698
A signpost to guide the key therapeutic components of Aralia continentalis Kitag roots in treating T2DM-derived heart attack, and diabetic nephropathy via systems biology concept., PMID:40274257
Rational molecular design of novel class-III peptidic antagonists to competitively disrupt human PPARδ self-binding peptide., PMID:40272659
Balancing Promise and Uncertainty: PPAR Agonists in IBD Therapy., PMID:40259682
Single and Multiple Doses of Seladelpar Decrease Diurnal Markers of Bile Acid Synthesis in Mice., PMID:40225907
Potentials of peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ: An in-depth and comprehensive review of their molecular mechanisms, cellular Signalling, immune responses and therapeutic implications in multiple diseases., PMID:40222274
High-Fat Diet in Perinatal Period Promotes Liver Steatosis and Low Desaturation Capacity of Polyunsaturated Fatty Acids in Dams: A Link with Anxiety-Like Behavior in Rats., PMID:40218938
Unraveling PPARβ/δ nuclear receptor agonists via a drug-repurposing approach: HTVS-based ligand identification, molecular dynamics, pharmacokinetics, and in vitro anti-steatotic validation., PMID:40190631
The role of Seladelpar in primary biliary cholangitis: a systematic review and meta-analysis., PMID:40188021
[Elucidating the Mechanisms of Lipid Accumulation in the Liver and Evaluating Potential Drug Targets]., PMID:40175144
Effects of candidate genes on milk fat synthesis in ruminants: A meta-analysis., PMID:40139354
Peroxisome proliferator-activated receptor beta/delta ligands as modulators of immune response in lipopolysaccharide-stimulated porcine endometrium: insights from an in vitro study., PMID:40137851
Latest FDA approved drug Elafibranor (Iqirvo): a novel prospect for treatment of primary biliary cholangitis., PMID:40109633
PPARγ/β/δ Agonists Can Ameliorate Dextran Sodium Sulfate-Induced Colitis and Modulate Gut Microbiota., PMID:40103411
Ferroptosis-Related Genes Are Effective Markers for Diagnostic Targets of Crohn's Disease., PMID:40084946
SMYD3 Activates Fatty Acid β-Oxidation to Promote Self-Renewal of Leukemia Stem Cells., PMID:40080525
Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD., PMID:40031093
Insights from Tandem Mass Tag (TMT) Proteomic Analysis on Protein Network Modification in Control of Yak Hair Follicle Cycle., PMID:40003997
Endothelial PPARδ Ablation Exacerbates Vascular Hyperpermeability via STAT1/CXCL10 Signaling in Acute Lung Injury., PMID:39996324
GW501516 facilitated tumor immune escape by inhibiting phagocytosis., PMID:39993702
Morroniside restrains renal glucose reabsorption to regulate glucose metabolism via the PPARδ/SGLT2 signaling pathway., PMID:39946985
Distinct Impact of Doxorubicin on Skeletal Muscle and Fat Metabolism in Mice: Without Dexrazoxane Effect., PMID:39940943
Transcriptomic analysis reveals the hepatopancreas metabolic mechanisms of mud crab Scylla paramamosain fed diets with terrestrial animal fat sources replacing fish oil., PMID:39922112
PPARβ/δ Activation Improves Corticosterone-Induced Oxidative Stress Damage in Astrocytes by Targeting UBR5/ATM Signaling., PMID:39921374
Peroxisome proliferator-activated receptors (PPARs) agonists as promising neurotherapeutics., PMID:39908735
Peroxisome proliferator-activated receptor delta and liver diseases., PMID:39899669
Elafibranor, a dual PPARα and PPARδ agonist, reduces alcohol-associated liver disease: Lessons from a mouse model., PMID:39877705
Phenolic and Iridoid Glycosides from Leonurus cardiaca L. and Their Effects on the α, δ, and γ Subtypes of the PPAR System-Including the Discovery of the Novel Phenylethanoid Cardiaphenyloside A and the Most Active 7-Chloro-6-desoxy-harpagide., PMID:39860288
Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases., PMID:39827490
[Bioinformatics and animal experiments reveal mechanism of Linggui Zhugan Decoction in ameliorating chronic heart failure after myocardial infarction via HIF-1α/HO-1 signaling pathway]., PMID:39805787
The role of PPAR in fungal keratitis., PMID:39763659
LC-MS profiling and cytotoxic activity of Angiopteris helferiana against HepG2 cell line: Molecular insight to investigate anticancer agent., PMID:39739862
Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome., PMID:39725014
Design, synthesis and biological evaluation of truncated 1'-homologated 4'-selenonucleosides as PPARγ/δ dual modulators., PMID:39705933
PPAR agonists for the treatment of cholestatic liver diseases: Over a decade of clinical progress., PMID:39699308
PPARβ/δ upregulates the insulin receptor β subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels., PMID:39696437
How PPAR-alpha mediated inflammation may affect the pathophysiology of chronic kidney disease., PMID:39665027
Modulation of Δ5- and Δ6-desaturases in the brain-liver axis., PMID:39642695
BUD23 promote the cell proliferation ability by affecting the PPAR signaling pathways: evidence from the online dataset and cell experiment., PMID:39636451
PPARδ Antagonist Inhibited CD47 Expression and Phagocytosis., PMID:39632616
EXPRESSION OF CONCERN: Rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-γ (PPAR-γ), reduce ischaemia/reperfusion injury of the gut., PMID:39623604
PPARβ/δ agonist GW0742 mitigates acute liver damage induced by acetaminophen overdose in mice., PMID:39617257
Antinociceptive, antineuropathic, and antimigraine-like activities ofFritillariaimperialis L. rich in verticinone on rats: Mechanisms of action., PMID:39613005
For research use only. Not for human or drug use.
