Catalog No.
YHF95501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu54-Val369
Predicted molecular weight
37.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02750
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ERK activator kinase 1, MKK1, MAPK/ERK kinase 1, MAPKK 1, MAP kinase kinase 1, MEK 1, MEK1, Dual specificity mitogen-activated protein kinase kinase 1, PRKMK1, MAP2K1
Unraveling Botulinum Neurotoxin A Light-Chain-Induced Signaling Pathways: A Phosphoproteomic Analysis in a Controlled Cellular Model., PMID:40507977
Exploration of Asparagus racemosus Willd for Alzheimer's Disease Through Integrated Metabolomics and Network Pharmacology Analyses Targeting BACE1 Protein., PMID:40483633
Activation of the MEK1-CHK2 axis in macrophages by Staphylococcus aureus promotes mitophagy, resulting in a reduction in bactericidal efficacy., PMID:40437411
Unusual Long-Term Survival in an Adult Patient With Langerhans Cell Histiocytosis and Central Nervous System Involvement: A Case Report., PMID:40416903
The discrepancies in amino acid sequence of the phosphate-binding loop lead to distinctive binding modes of a covalent inhibitor for MAP2K1 and MAP2K6: Structural insights for producing selective inhibitors., PMID:40378928
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson's disease., PMID:40367191
miR-369-3p Ameliorates Inflammation and Apoptosis in Intestinal Epithelial Cells via the MEK/ERK Signaling Pathway., PMID:40362525
Radiation-induced esophagitis and lung injury during esophageal squamous cell cancer therapy is correlated to tumor gene expression phenotype., PMID:40331088
Clinicopathological and molecular characterization of KRAS wild-type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes., PMID:40317966
Mechanical stress facilitates calcium influx and growth of alveolar epithelial cells via activation of the BDKRB1/Ca2+/CaMKII/MEK1/ERK axis., PMID:40296124
Molecular Mechanism of Perfluorooctane Sulfonate-Induced Lung Injury Mediated by the Ras/Rap Signaling Pathway in Mice., PMID:40278636
The identification of functional regions of MEK1 using CRISPR tiling screens., PMID:40274952
Regulation of the MAPK/ERK Pathway by miRNA-27b in Gastric Cancer: Diagnostic Implications and Therapeutic Potential of Aloin., PMID:40240889
Sanqi Qushi formula ameliorates renal injury in experimental membranous nephropathy rats by inhibiting the MEK/ERK signaling pathway., PMID:40239880
Pleurotus ostreatus mek1 is essential for meiosis and basidiospore production., PMID:40222769
Molecular Pathogenesis of the Histiocytic and Dendritic Cell Neoplasms., PMID:40221268
A Phase Ia/b study of MEK1/2 inhibitor binimetinib with MET inhibitor crizotinib in patients with RAS mutant advanced colorectal cancer (MErCuRIC)., PMID:40211189
Integration of network pharmacology and experimental validation to explore the pharmacological mechanism of andrographolide against asthma., PMID:40198539
Monocytic meningitis complicating histiocytosis and response to MEK-inhibitor: a case series., PMID:40131415
Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumours., PMID:40107205
Ras-MAPK pathway in patients with lupus nephritis., PMID:40102014
Negative Hyperselection in Metastatic Colorectal Cancer for First-Line Anti-EGFR Therapy: A Narrative Review., PMID:40076838
Retrospective nationwide survey of pediatric RDD in Japan: a high prevalence of mutations in the kinase pathway genes., PMID:40063331
MEK1 inhibition ameliorates mitochondrial-dependent apoptosis induced by deltamethrin in mouse hippocampal neuron HT22 cells., PMID:40058615
Identification of Candidate Alterations Mediating KRASG12C Inhibitor Resistance in Advanced Colorectal and Pancreatic Cancers., PMID:40025995
Antiviral Activity of the MEK1/2 Inhibitor Trametinib Against Lymphocytic Choriomeningitis Virus., PMID:40008425
Langerhans Cell Histiocytosis and Other Histiocytic Lesions., PMID:39998733
Effects of F53 hotspot mutations on the molecular dynamics of MEK1 protein and the binding of its FDA-approved inhibitors., PMID:39986525
Extracellular vesicle-mediated gene therapy targets BRAFV600E-mutant colorectal cancer by inhibiting the MEK1/2-ERK1/2 pathway., PMID:39979881
Influenza H5Nx viruses are susceptible to MEK1/2 inhibition by zapnometinib., PMID:39976482
Design and Synthesis of Novel MEK Inhibitors for the Treatment of Solid Tumors., PMID:39968603
Clinical Activity of Mitogen-Activated Protein Kinase Inhibitors in Patients With MAP2K1 (MEK1)-Mutated Metastatic Cancers., PMID:39869838
Circulating Tumor Cell-Free DNA as Prognostic Biomarker in Non-Small Cell Lung Cancer Patients Undergoing Immunotherapy: The CORELAB Experience., PMID:39859325
Integrating functional proteomics and next generation sequencing reveals potential therapeutic targets for Taiwanese breast cancer., PMID:39844043
Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma., PMID:39835132
Rathke cleft cyst with squamous metaplasia and activating mutations of mitogen-activated protein kinase signaling: illustrative case., PMID:39832308
Sialoblastomas With Solid Pattern Have FGFR2 Mutations and an Unfavorable Prognosis., PMID:39807824
E203K mutation in MAP2K1 (MEK1) causes acquired resistance to PD-1 blockade but responds to trametinib: a case report., PMID:39806853
Clinical, Morphologic, and Genomic Differences in Deep-Penetrating Nevi and Deep-Penetrating Nevus-like Melanomas., PMID:39793705
FGF21 Exhibits Neuroprotective Effects by Promoting 5-HT1AR-FGFR1 Heteroreceptor Complexes and Triggering MEK1/2-ERK1/2 Signaling Pathway., PMID:39789238
Serum pharmacochemistry combined with network pharmacology reveals the hepatotoxicity mechanism of Alangium chinense (Lour.) Harms., PMID:39746409
[Correlation of BRAF V600E Mutation with Clinical Features and Prognosis of Langerhans Cell Histiocytosis in Cildren]., PMID:39743286
Synergistic two-step inhibition approach using a combination of trametinib and onvansertib in KRAS and TP53-mutated colorectal adenocarcinoma., PMID:39731938
The Activation of the CCND1 Promoter by AP-1 and SOX Transcription Factors in PC3 Prostate Cancer Cells Can Be Prevented by Anacardic Acid Analogs., PMID:39729169
Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes., PMID:39722169
Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children., PMID:39711503
DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells., PMID:39671288
Integrin α1 upregulation by TF:FVIIa complex promotes cervical cancer migration through PAR2-dependent MEK1/2 activation., PMID:39657349
[Clinicopathological analysis of 48 children with Langerhans cell histiocytosis]., PMID:39648010
For research use only. Not for human or drug use.
