Catalog No.
YHF94801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly128-Val426
Predicted molecular weight
35.79 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02556
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interferon regulatory factor 8, H-ICSBP, IRF-8, ICSBP1, ICSBP, IRF8, Interferon consensus sequence-binding protein
IRF8 facilitates bovine ephemeral fever virus replication by downregulating IRF9., PMID:40513519
Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC., PMID:40494892
IRF8-Cathepsin S/PAR2 axis-mediated spinal microglia-neuron crosstalk is responsible for the exacerbation of postsurgical pain induced by preoperative stress., PMID:40482455
Cardiomyocyte pyroptosis inhibited by dental pulp-derived mesenchymal stem cells via the miR-19a-3p/IRF-8/MAPK pathway in ischemia-reperfusion., PMID:40474332
Interferon regulatory factor 8 induces intrinsic functional changes in mature neutrophils., PMID:40457627
Identification and characterization of interferon regulatory factor 8 (IRF8) in Nile tilapia (Oreochromisniloticus)., PMID:40447206
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity., PMID:40436823
C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development., PMID:40378239
CRISPRi screen uncovers lncRNA regulators of human monocyte growth., PMID:40345583
Role of USP7 in the regulation of tolerogenic dendritic cell function in type 1 diabetes., PMID:40247205
Sex-dependent effect of GPR109A gene deletion in myeloid cells on bone development in mice., PMID:40235504
IRF4-regulated transcriptional and functional heterogeneity of lung-resident CD11b+ cDC2 subsets during influenza virus infection., PMID:40209091
Whole Transcriptome RNA-Seq Reveals Drivers of Pathological Dysfunction in a Transgenic Model of Alzheimer's Disease., PMID:40186694
IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development., PMID:40184622
Modulation of the tumor immune microenvironment by Interferon Regulatory Factor 8 enhances immunotherapy in lung adenocarcinoma., PMID:40113982
A novel dominant-negative variant of IRF8 in a mother and son: Clinical, phenotypic and biological characteristics., PMID:40072380
Mechanism of IRF8 on osteocyte apoptosis in steroid-induced osteonecrosis of the femoral head., PMID:40055968
Identification of an IRF8 gene in common carp (Cyprinus carpio. L) and its regulatory role in immune responses., PMID:40038681
Transcriptomic and biometric parameters analysis in rainbow trout (Oncorhynchus mykiss) challenged with viral hemorrhagic septicemia virus (VHSV)., PMID:40021981
Synergistic and antagonistic activities of IRF8 and FOS enhancer pairs during an immune-cell fate switch., PMID:39972074
Exploring the role of the IL-12/IFN-γ immune axis in subacute sclerosing panencephalitis., PMID:39955927
Signature Construction Associated with Tumor-Infiltrating Macrophages Identifies IRF8 as a Novel Biomarker for Immunotherapy in Advanced Gastric Cancer., PMID:39940857
The characterization of a novel IRF8-like homolog and its role in the immune modulation of the sea urchin Strongylocentrotus intermedius., PMID:39922248
Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways., PMID:39878951
Early transcriptional effects of inflammatory cytokines reveal highly redundant cytokine networks., PMID:39873673
Utilising bioinformatics and systems biology methods to uncover the impact of dermatomyositis on interstitial lung disease., PMID:39808289
Comprehensive analysis of IRF8-related genes and immune characteristics in lupus nephritis., PMID:39717551
CRISPRi Screen Uncovers lncRNA Regulators of Human Monocyte Growth., PMID:39651253
Novel Perspective on Sevoflurane-Induced Cognitive Dysfunction: Implications of Neuronal SIRPα and Microglial Synaptic Remodeling., PMID:39644326
IRF8 Demonstrates Positivity in a Significant Subset of Histiocytic and Dendritic Cell Neoplasms., PMID:39569507
Insights in AAV-mediated antigen-specific immunity and a strategy for AAV vaccine dose reduction through AAV-extracellular vesicle association., PMID:39559560
Sphingosine 1-phosphate receptor 1signaling in macrophages reduces atherosclerosis in LDL receptor-deficient mice., PMID:39531328
Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers., PMID:39516198
Sex-specific transcriptomic effects of low-dose inorganic arsenic exposure on bone marrow-derived macrophages., PMID:39515575
A New Frontier in Tumor Eradication: Harnessing In Vivo Cellular Reprogramming for Durable Cancer Immunotherapy., PMID:39387283
Optimization of the Irf8 +32-kb enhancer disrupts dendritic cell lineage segregation., PMID:39375550
Inhibition of hepatitis B virus through PPAR-JAK/STAT pathway modulation by electroacupuncture and tenofovir disoproxil fumarate combination therapy., PMID:39369463
Targeted immune cell therapy for hepatocellular carcinoma using expanded liver mononuclear cell-derived natural killer cells., PMID:39357263
Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells., PMID:39345451
IRF8 as durable architect of the microglial chromatin landscape., PMID:39313545
IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs., PMID:39313544
Anatomy of a superenhancer., PMID:39271259
In vivo dendritic cell reprogramming for cancer immunotherapy., PMID:39236156
Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage., PMID:39209978
Transcriptomic response of lumpfish (Cyclopterus lumpus) head kidney to viral mimic, with a focus on the interferon regulatory factor family., PMID:39211041
Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development., PMID:39179932
CgIκB2 negatively regulates the expression of interferon-like protein by Rel/NF-κB signal in Crassostrea gigas., PMID:39173983
Interferon regulatory factor 8-driven reprogramming of the immune microenvironment enhances antitumor adaptive immunity and reduces immunosuppression in murine glioblastoma., PMID:39115195
Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function., PMID:39052479
A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo., PMID:39052000
For research use only. Not for human or drug use.
