Catalog No.
YHF94101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg136-Cys471
Predicted molecular weight
40.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02487
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Desmosomal glycoprotein II, Desmocollin-2, DSC2, DSC3, Cadherin family member 2, CDHF2, Desmosomal glycoprotein III, Desmocollin-3
Genomic and molecular evidence that the lncRNA DSP-AS1 modulates Desmoplakin expression., PMID:40236443
Modified mRNA Treatment Restores Cardiac Function in Desmocollin-2-Deficient Mouse Models of Arrhythmogenic Right Ventricular Cardiomyopathy., PMID:40211944
Natural History and Clinical Outcomes of Patients With DSG2/DSC2 Variant-Related Arrhythmogenic Right Ventricular Cardiomyopathy., PMID:40123482
Predicted Risk of Ventricular Arrhythmias in a Genome-First Population With Genetic Risk for Arrhythmogenic Right Ventricular Cardiomyopathy., PMID:39989366
MicroRNA-32-5p promotes the proliferation and metastasis of gastric cancer cells., PMID:39833289
MCP-enhanced SOD3 activity inhibits gastric cancer and potentiate chemotherapy via modulating EGFR signaling., PMID:39746602
Genome-wide association studies of milk composition traits in indicine Badri cattle using ddRAD sequencing approach., PMID:39715884
Electrophysiological Phenotype-Genotype Study of Sustained Monomorphic Ventricular Tachycardia in Inherited, High Arrhythmic Risk, Left Ventricular Cardiomyopathy., PMID:39611258
The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi., PMID:39461958
Latrophilin-2 Deletion in Cardiomyocyte Disrupts Cell Junction, Leading to D-CMP., PMID:39421931
Unveiling the glycolysis in sepsis: Integrated bioinformatics and machine learning analysis identifies crucial roles for IER3, DSC2, and PPARG in disease pathogenesis., PMID:39331858
Arrhythmogenic cardiomyopathy-related cadherin variants affect desmosomal binding kinetics., PMID:39079569
Immunohistopathological analyses of a case of pemphigus vegetans with antibodies against desmoglein 1 and desmocollins 1-3., PMID:39073162
Acute hepatotoxicity of intravenous amiodarone in a Becker muscular dystrophy patient with decompensated heart failing and ABCB4 gene mutation: as assessed for causality using the updated RUCAM., PMID:39044225
Further exploration of cardiac channelopathy and cardiomyopathy genes in stillbirth., PMID:38813989
Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer., PMID:38671389
Molecular genetic screening after non-ischaemic sudden cardiac arrest and no overt cardiomyopathy in real life: A major tool for the aetiological diagnostic work-up., PMID:38670870
Experimentally validated oxidative stress -associated prognostic signatures describe the immune landscape and predict the drug response and prognosis of SKCM., PMID:38660305
A Retrospective View of the Triple-Negative Breast Cancer Microenvironment: Novel Markers, Interactions, and Mechanisms of Tumor-Associated Components Using Public Single-Cell RNA-Seq Datasets., PMID:38539508
Cardiac desmosomal adhesion relies on ideal-, slip- and catch bonds., PMID:38297017
Understanding Arrhythmogenic Cardiomyopathy: Advances through the Use of Human Pluripotent Stem Cell Models., PMID:37895213
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway., PMID:37421607
A Systematic Analysis of the Clinical Outcome Associated with Multiple Reclassified Desmosomal Gene Variants in Arrhythmogenic Right Ventricular Cardiomyopathy Patients., PMID:37418234
Staphylococcus aureus induces tolerance in human monocytes accompanied with expression changes of cell surface markers., PMID:37063823
The role of the desmosomal protein desmocollin 2 in tumour progression in triple negative breast cancer patients., PMID:36927383
Ginsenoside Rg1 as a promising adjuvant agent for enhancing the anti-cancer functions of granulocytes inhibited by noradrenaline., PMID:36817446
Alterations in Calcium Handling Are a Common Feature in an Arrhythmogenic Cardiomyopathy Cell Model Triggered by Desmosome Genes Loss., PMID:36768439
Comprehensive analysis of roles of atrial-fibrillation-related genes in lung adenocarcinoma using bioinformatic methods., PMID:36542177
Syncope in the athlete - Minor changes, major diagnosis!, PMID:36442584
Revealing the Changes in Saliva and Serum Proteins of Pigs with Meningitis Caused by Streptococcus Suis: A Proteomic Approach., PMID:36430174
Desmocollin-2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma via the ERK/c-MYC signaling pathway., PMID:36367775
Cortical tension regulates desmosomal morphogenesis., PMID:36268507
Salivary proteomic analysis in asymptomatic and symptomatic SARS-CoV-2 infection: Innate immunity, taste perception and FABP5 proteins make the difference., PMID:36228679
Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions., PMID:36196449
Towards a Better Understanding of Genotype-Phenotype Correlations and Therapeutic Targets for Cardiocutaneous Genes: The Importance of Functional Studies above Prediction., PMID:36142674
DSC2 Suppresses the Metastasis of Gastric Cancer through Inhibiting the BRD4/Snail Signaling Pathway and the Transcriptional Activity of β-Catenin., PMID:36120591
Burden of rare variants in arrhythmogenic cardiomyopathy with right dominant form-associated genes provides new insights for molecular diagnosis and clinical management., PMID:35819174
Fecal luminal factors from patients with irritable bowel syndrome induce distinct gene expression of colonoids., PMID:35485994
The PPARγ pathway determines electrophysiological remodelling and arrhythmia risks in DSC2 arrhythmogenic cardiomyopathy., PMID:35297182
Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy., PMID:35288587
Desmoglein 2 can undergo Ca2+-dependent interactions with both desmosomal and classical cadherins including E-cadherin and N-cadherin., PMID:35183520
Premature Termination Codon in 5' Region of Desmoplakin and Plakoglobin Genes May Escape Nonsense-Mediated Decay through the Reinitiation of Translation., PMID:35054841
Androgen downregulates desmocollin-2 in association with induction of mesenchymal transition of breast MDA-MB-453 cancer cells., PMID:35023302
[Genetics of complex and syndromic palmoplantar keratoderma]., PMID:34961738
Overlap phenotypes of the left ventricular noncompaction and hypertrophic cardiomyopathy with complex arrhythmias and heart failure induced by the novel truncated DSC2 mutation., PMID:34819141
Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system., PMID:34586853
Deleterious Rare Desmosomal Variants Contribute to Hypertrophic Cardiomyopathy and Are Associated With Distinctive Clinical Features., PMID:34500006
Genotype-phenotype correlation in arrhythmogenic right ventricular cardiomyopathy-risk of arrhythmias and heart failure., PMID:34400560
Two Novel Variants in Genes of Arrhythmogenic Right Ventricular Cardiomyopathy - a Case Report., PMID:34393635
For research use only. Not for human or drug use.
