Catalog No.
YHF91401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser29-Phe125
Predicted molecular weight
13.27 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02083
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
N-acylsphingosine amidohydrolase-like, N-acylethanolamine-hydrolyzing acid amidase, ASAH-like protein, ASAHL, PLT, Acid ceramidase-like protein, NAAA, Acylsphingosine deacylase NAAA
Chemical Probes for Investigating the Endocannabinoid System., PMID:39747798
Endometrial Cell-Type Specific Regulation of the Endocannabinoids System and the Impact of Menstrual Cycle and Endometriosis., PMID:39286880
Pharmacological Inhibition of N-Acylethanolamine Acid Amidase (NAAA) Mitigates Intestinal Fibrosis Through Modulation of Macrophage Activity., PMID:39211986
Altered transcriptomes, cell type proportions, and dendritic spine morphology in hippocampus of suicide decedents., PMID:39191313
Combined in vivo effect of N-acylethanolamine-hydrolyzing acid amidase and glycogen synthase kinase-3β inhibition to treat multiple sclerosis., PMID:38701570
CSF N-acylethanolamine acid amidase level and Parkinson's disease risk: A mendelian randomization study., PMID:38579440
NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice., PMID:38402219
Mulberry (Morus alba L.) leaf water extract attenuates type 2 diabetes mellitus by regulating gut microbiota dysbiosis, lipopolysaccharide elevation and endocannabinoid system disorder., PMID:38163557
Inhibiting immunoregulatory amidase NAAA blocks ZIKV maturation in Human Neural Stem Cells., PMID:37414288
Ramulus Cinnamomi essential oil exerts an anti-inflammatory effect on RAW264.7 cells through N-acylethanolamine acid amidase inhibition., PMID:37311500
Key Risk Genes Identified From the Postmortem Brain of Patients With Major Depressive Disorder and Their Potential Clinical Applications., PMID:37235790
Smoking during pregnancy is associated with the placental proteome., PMID:37209868
Association of muscular strength and targeted proteomics involved in brain health in children with overweight/obesity., PMID:37190796
Identification of diagnostic biomarks and immune cell infiltration in ulcerative colitis., PMID:37055577
Plasma levels of neurology-related proteins are associated with cognitive performance in an older population with overweight/obesity and metabolic syndrome., PMID:36964401
Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA)., PMID:36564457
N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation., PMID:36244543
N-acylethanolamide metabolizing enzymes are upregulated in human neural progenitor-derived neurons exposed to sub-lethal oxidative stress., PMID:36003139
Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism., PMID:35781057
Structural determinants of acid-sensing ion channel potentiation by single chain lipids., PMID:35583813
Insights Into the Prognostic Value and Immunological Role of NAAA in Pan-Cancer., PMID:35069601
Assessment of the Effects of Dietary Vitamin D Levels on Olanzapine-Induced Metabolic Side Effects: Focus on the Endocannabinoidome-Gut Microbiome Axis., PMID:34830242
N-Acylethanolamine acid amidase (NAAA) is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth., PMID:34791641
PM20D1 is a circulating biomarker closely associated with obesity, insulin resistance and metabolic syndrome., PMID:34757919
NAAA inhibitor F96 attenuates BBB disruption and secondary injury after traumatic brain injury (TBI)., PMID:34655598
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration., PMID:34469137
Inhibition of N-acylethanolamine-hydrolyzing acid amidase reduces T cell infiltration in a mouse model of multiple sclerosis., PMID:34391933
N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice., PMID:34235639
Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines., PMID:34033896
Functional variants in the chromosome 4q21 locus contribute to allergic rhinitis risk by modulating the expression of N-acylethanolamine acid amidase., PMID:33866639
N-acylethanolamine-hydrolysing acid amidase: A new potential target to treat paclitaxel-induced neuropathy., PMID:33675555
Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFβ signaling through PPARα., PMID:33385371
Synergic Therapeutic Potential of PEA-Um Treatment and NAAA Enzyme Silencing In the Management of Neuroinflammation., PMID:33050589
Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations., PMID:33028409
N-Acylethanolamine Acid Amidase contributes to disease progression in a mouse model of multiple sclerosis., PMID:32634582
Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway., PMID:32326173
Effects of orthotopic implantation of rat prostate tumour cells upon components of the N-acylethanolamine and monoacylglycerol signalling systems: an mRNA study., PMID:32286386
N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition., PMID:32191459
Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity., PMID:31878942
Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors., PMID:31761726
Genetic Polymorphisms on 4q21.1 Contributed to the Risk of Hashimoto's Thyroiditis., PMID:31750736
A New Use for an Old Drug: Carmofur Attenuates Lipopolysaccharide (LPS)-Induced Acute Lung Injury via Inhibition of FAAH and NAAA Activities., PMID:31379583
N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis., PMID:31063807
Microbial Degradation of Nicotinamide by a Strain Alcaligenes sp. P156., PMID:30842479
N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion., PMID:30660740
Molecular mechanism of activation of the immunoregulatory amidase NAAA., PMID:30301806
Structural and Functional Interaction of Δ9-Tetrahydrocannabinol with Liver Fatty Acid Binding Protein (FABP1)., PMID:30232874
Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush., PMID:30217164
Inflammation-restricted anti-inflammatory activities of a N-acylethanolamine acid amidase (NAAA) inhibitor F215., PMID:29572189
For research use only. Not for human or drug use.
