Catalog No.
YHF90601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp318-Lys468
Predicted molecular weight
19.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01970
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Phospholipase C-beta-3, PLC-beta-3, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, Phosphoinositide phospholipase C-beta-3, PLCB3
Cerebellar Molecular Signatures in Non-Human Primates., PMID:39439015
Tibial cortex transverse transport surgery improves wound healing in patients with severe type 2 DFUs by activating a systemic immune response: a cross-sectional study., PMID:38954658
Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia., PMID:38945956
Cetuximab inhibits colorectal cancer development through inactivating the Wnt/β-catenin pathway and modulating PLCB3 expression., PMID:38724565
OSBPL2 compound heterozygous variants cause dyschromatosis, ichthyosis, deafness and atopic disease syndrome., PMID:38701954
TRPM4 and PLCβ3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCβ3 is not needed for taste-driven licking for glucose., PMID:38183495
Illuminating (HTLV-1)-induced adult T-cell leukemia/lymphoma transcriptomic signature: A systems virology approach., PMID:37832654
A regulatory node involving Gαq, PLCβ, and RGS proteins modulates platelet reactivity to critical agonists., PMID:37657560
Extension domain of amyloid processor protein inhibits amyloidogenic cleavage and balances neural activity in a traumatic brain injury mouse model., PMID:37592823
Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI(4,5)P2 hydrolysis in the plasma membrane., PMID:37172724
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Myocardial Infarction Injury via miR-24-3p-Promoted M2 Macrophage Polarization., PMID:35818695
Insulin-like growth factor-1 inhibits apoptosis of rat gastric smooth muscle cells under high glucose condition via adenosine monophosphate-activated protein kinase (AMPK) pathway., PMID:35156189
Designer proteins that competitively inhibit Gαq by targeting its effector site., PMID:34715131
Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels., PMID:34670408
Quantitative Determination and Imaging of Gαq Signaling in Live Cells via Split-Luciferase Complementation., PMID:34050463
Six Glycolysis-Related Genes as Prognostic Risk Markers Can Predict the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma., PMID:33628816
iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells., PMID:33405298
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals., PMID:33230300
Phospholipase Cβ3 in the hippocampus may mediate impairment of memory by long-term blockade of orexin 1 receptors assessed by the Morris water maze., PMID:32622948
An integrative bioinformatics analysis of caprine GNAI3 gene., PMID:32366735
Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum., PMID:32360594
Is MYND Domain-Mediated Assembly of SMYD3 Complexes Involved in Calcium Dependent Signaling?, PMID:31737645
Mal protein stabilizes luminal membrane PLC-β3 and negatively regulates ENaC in mouse cortical collecting duct cells., PMID:31364376
Intramolecular electrostatic interactions contribute to phospholipase Cβ3 autoinhibition., PMID:31254604
Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma., PMID:31080817
Diagnostic and prognostic value of mRNA expression of phospholipase C β family genes in hepatitis B virus‑associated hepatocellular carcinoma., PMID:30896816
Integrated Analysis of Whole Exome Sequencing and Copy Number Evaluation in Parkinson's Disease., PMID:30833663
Acetylshikonin stimulates glucose uptake in L6 myotubes via a PLC-β3/PKCδ-dependent pathway., PMID:30780104
A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells., PMID:30464299
Aortic constriction induces hypertension and cardiac hypertrophy via (pro)renin receptor activation and the PLC‑β3 signaling pathway., PMID:30431106
OSBP-related protein 4L promotes phospholipase Cβ3 translocation from the nucleus to the plasma membrane in Jurkat T-cells., PMID:30237164
Regulation of actin assembly by PI(4,5)P2 and other inositol phospholipids: An update on possible mechanisms., PMID:30139519
Therapeutic effects of JLX001 on cerebral ischemia through inhibiting platelet activation and thrombus formation in rats., PMID:29990874
A Genome-Wide Linkage Study for Chronic Obstructive Pulmonary Disease in a Dutch Genetic Isolate Identifies Novel Rare Candidate Variants., PMID:29725345
PLCB3 Loss of Function Reduces Pseudomonas aeruginosa-Dependent IL-8 Release in Cystic Fibrosis., PMID:29668297
A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes., PMID:29263090
TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice., PMID:29146750
Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy., PMID:29122926
Phospholipase Cβ3 Membrane Adsorption and Activation Are Regulated by Its C-Terminal Domains and Phosphatidylinositol 4,5-Bisphosphate., PMID:28945350
PDZK1 inhibits the development and progression of renal cell carcinoma by suppression of SHP-1 phosphorylation., PMID:28692056
The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets., PMID:28615442
Altered nucleocytoplasmic proteome and transcriptome distributions in an in vitro model of amyotrophic lateral sclerosis., PMID:28453527
RACK1 regulates angiotensin II-induced contractions of SHR preglomerular vascular smooth muscle cells., PMID:28100502
CAPE suppresses migration and invasion of prostate cancer cells via activation of non-canonical Wnt signaling., PMID:27191743
ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival., PMID:27581363
Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway., PMID:27311705
IL-1ra Secreted by ATP-Induced P2Y2 Negatively Regulates MUC5AC Overproduction via PLCβ3 during Airway Inflammation., PMID:27034593
Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site., PMID:27002154
PLCβ3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration., PMID:26490115
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor., PMID:26218440
For research use only. Not for human or drug use.
