Catalog No.
YHF90301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu1428-His1670
Predicted molecular weight
53.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01955
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Goodpasture antigen, Collagen alpha-3(IV) chain, COL4A3
[New Genetic Variants Involved in the Pathogenesis of Autosomal Dominant Alport Syndrome: A Familial Case Report]., PMID:40332975
Whole exome sequencing shows novel COL4A3 and COL4A4 variants as causes of Alport syndrome in Rio Grande do Norte, Brazil., PMID:40169949
Pathogenic variants in the Alport genes are prevalent in the Singapore multiethnic population with highest frequency in the Chinese., PMID:40044766
Molecular Review of Suspected Alport Syndrome Patients-A Single-Centre Experience., PMID:40004525
Effects of a Novel COL4A3 Homozygous/Heterozygous Splicing Mutation on the Mild Phenotype in a Family With Autosomal Recessive Alport Syndrome and a Literature Review., PMID:39924725
Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome model., PMID:39908276
A 15-year experience highlighting the spectrum of Alport kidney disease in the pediatric population and novel genetic variants in COL4A3-5., PMID:39907758
[Clinical and genetic features of persistent asymptomatic microscopic hematuria in children]., PMID:39844494
Engineered antigen-specific T regulatory cells suppress autoreactivity to the anti-glomerular basement membrane disease antigen., PMID:39842638
Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome., PMID:39680378
Diagnosis, management and treatment of the Alport syndrome - 2024 guideline on behalf of ERKNet, ERA and ESPN., PMID:39673454
Synergistic toxicity of compound heterozygous mutations in the COL4A3 gene causes end-stage renal disease in A large family of Alport syndrome., PMID:39615805
Noninvasive genetic testing for type IV collagen nephropathy using oral mucosa DNA sampling in children with haematuria., PMID:39540369
Slowly progressive autosomal dominant Alport Syndrome due to COL4A3 splicing variant., PMID:39424670
Detection of Alport gene variants in children and young people with persistent haematuria., PMID:39349776
Spectrum of Alport syndrome in an Indian cohort., PMID:39278986
Hyperphosphatemia Contributes to Skeletal Muscle Atrophy in Mice., PMID:39273260
Quantifying variant contributions in cystic kidney disease using national-scale whole-genome sequencing., PMID:39190485
Chemical chaperones to the rescue of Alport syndrome?, PMID:39174196
Genetic study of Alport syndrome in Tunisia., PMID:39138691
Characterization of Ocular Morphology in Col4a3-/- Mice as a Murine Model for Alport Syndrome., PMID:39042048
Four novel mutations identified in the COL4A3, COL4A4 and COL4A5 genes in 10 families with Alport syndrome., PMID:38978054
Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study., PMID:38972501
Genotype-Phenotype Correlations in Alport Syndrome-A Single-Center Experience., PMID:38790222
Tauroursodeoxycholic acid ameliorates renal injury induced by COL4A3 mutation., PMID:38782199
Coexisting presentation of two rare genetic variants of autosomal dominant polycystic kidney disease and Alport syndrome., PMID:38740443
Genetic diagnosis of Alport syndrome in 16 Chinese families., PMID:38433557
Increased prevalence of kidney cysts in individuals carrying heterozygous COL4A3 or COL4A4 pathogenic variants., PMID:38317457
Cystic phenotype and chronic kidney disease in autosomal dominant Alport syndrome., PMID:38178635
Collagen IV of basement membranes: II. Emergence of collagen IVα345 enabled the assembly of a compact GBM as an ultrafilter in mammalian kidneys., PMID:37977222
Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis., PMID:36152127
Clinical and histopathological characteristics of COL4A3 c.2881+1G>A variant causing Alport spectrum disorders in Croatian population., PMID:35880347
Col4a3-/- Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds., PMID:35743114
Genetic heterogeneity in GJB2, COL4A3, ATP6V1B1 and EDNRB variants detected among hearing impaired families in Morocco., PMID:35301649
Genotype-phenotype correlations for COL4A3-COL4A5 variants resulting in Gly substitutions in Alport syndrome., PMID:35177655
Disruption of the glomerular basement membrane associated with nutcracker syndrome and double inferior vena cava in Noonan syndrome: a case report., PMID:35151252
Heterozygous COL4A3/COL4A4 mutations: the hidden part of the iceberg?, PMID:35090027
Guidelines for Genetic Testing and Management of Alport Syndrome., PMID:34930753
Generation of the induced pluripotent stem cell line (NCKDi004-A) from a 17-year-old patient with Alport syndrome carrying a homozygous mutation in COL4A3 gene., PMID:34626894
Busulfan impairs blood-testis barrier and spermatogenesis by increasing noncollagenous 1 domain peptide via matrix metalloproteinase 9., PMID:34535976
Prevalence Estimates of Predicted Pathogenic COL4A3-COL4A5 Variants in a Population Sequencing Database and Their Implications for Alport Syndrome., PMID:34400539
COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy., PMID:34326188
Neutralization of IL-6 inhibits formation of autoreactive TH17 cells but does not prevent loss of renal function in experimental autoimmune glomerulonephritis., PMID:34015360
Tumstatin attenuates the promotion effect of IL-17 secreted by Th17 cells on the stemness maintenance of glioma cells., PMID:33971545
Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease., PMID:33893224
Consensus statement on standards and guidelines for the molecular diagnostics of Alport syndrome: refining the ACMG criteria., PMID:33854215
Could This Be Alport Syndrome?, PMID:33849931
Clinical and Genetic Features of Autosomal Dominant Alport Syndrome: A Cohort Study., PMID:33838161
Carvedilol and exercise combination therapy improves systolic but not diastolic function and reduces plasma osteopontin in Col4a3-/- Alport mice., PMID:33769915
Next-generation sequencing in patients with familial FSGS: first report of collagen gene mutations in Tunisian patients., PMID:33654185
For research use only. Not for human or drug use.
