Catalog No.
YHF90001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser136-Ser289
Predicted molecular weight
20.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01860
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Octamer-binding protein 4, Oct-4, OCT3, OCT4, OTF3, OTF-3, Octamer-binding transcription factor 3, POU5F1, Oct-3, POU domain, class 5, transcription factor 1, Octamer-binding protein 3
Exosomal POU5 F1 derived from TNBC promotes cancer progression by regulating M2 macrophage polarization via inhibiting TRAF6 ubiquitination and activating AKT in macrophage., PMID:40461859
OCT4 and MENA immunoprofiling in salivary mucoepidermoid carcinoma., PMID:40426241
p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance., PMID:40410129
Viral-mediated Pou5f1 (Oct4) overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia., PMID:40388211
Nuclear circGUSBP1 promotes cancer stemness via transcriptional coordination with OCT4., PMID:40360086
ATR regulates OCT4 phosphorylation and safeguards human naïve pluripotency., PMID:40312477
Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival., PMID:40301302
Bimodal specificity of TF-DNA recognition in embryonic stem cells., PMID:40287827
Solute carrier family 2 member 2 (glucose transporter 2): a common factor of hepatocyte and hepatocellular carcinoma differentiation., PMID:40279337
A dual-Color closed bipolar electrochemiluminescence platform for visual simultaneous diagnosis of two pluripotency markers in cancer patients' urine., PMID:40253801
Nicotine-driven enhancement of tumor malignancy in triple-negative breast cancer via additive regulation of CHRNA9 and IGF1R., PMID:40244072
Multifaceted roles of OCT4 in tumor microenvironment: biology and therapeutic implications., PMID:40229384
The mediating mechanism of Oct4 in the process of cleft palate induced by 2, 3, 7, 8-tetrachlorodibenz-p-dioxin (TCDD) and all-trans retinoic acid., PMID:40194363
Potential use of human pluripotency-related gene expression reporter cell line for screening small molecules to enhance induction of pluripotency., PMID:40176603
A Simple Method for Generating Light-induced Clusters of Transcription Factors: Effects on the Nuclear Distribution of OCT4 and on its Interactions With Chromatin., PMID:40174669
Mangiferin promotes porcine oocyte maturation and delays the postovulatory aging process by up-regulating NRF2 levels., PMID:40086422
Mechanistic insights into SENP1 and OCT4 interaction in promoting drug resistance and stem cell features in colon cancer., PMID:40063360
Induction of SOX17 with stimulation of WNT, TGF-beta, and FGF signaling drives embryonal carcinomas into the yolk-sac tumor lineage resulting in increased cisplatin resistance., PMID:40025812
Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in early mouse embryos., PMID:40014376
OCT4 translationally promotes AKT signaling as an RNA-binding protein in stressed pluripotent stem cells., PMID:39988663
FBF1 maintains stem cell-like properties in breast cancer via PI3K/AKT/SOX2 axis., PMID:39988656
Characterization of DNA methylation profile of the entire CpG island spanning the 5' untranslated region to intron 1 of the Oct4/POU5F1 gene in bovine gametes, embryos, and somatic cells., PMID:39953930
Investigating the expression and role of N-Myc in spermatogonial stem cells and male infertility., PMID:39947263
DNA methylation of POU5F1 by DNMT1 and DNMT3B triggers apoptosis in interstitial Cajal-like cells via c-kit/SCF inhibition during cholesterol gallstone formation., PMID:39899939
OCT4 promotes lung cancer progression through upregulation of VEGF-correlated chemokine-1., PMID:39898238
Dandelion extract suppresses the stem-like properties of triple-negative breast cancer cells by regulating CUEDC2/β-catenin/OCT4 signaling axis., PMID:39864604
Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer., PMID:39849876
Integrating single cell analysis and machine learning methods reveals stem cell-related gene S100A10 as an important target for prediction of liver cancer diagnosis and immunotherapy., PMID:39840058
The role of OCT4 and CD44 in lower lip carcinogenesis., PMID:39820576
Dual-stimuli-responsive nanoparticles for the co-delivery of small molecules to promote neural differentiation of human iPSCs., PMID:39815767
Profiling of snoRNAs in Exosomes Secreted from Cells Infected with Influenza A Virus., PMID:39795871
Fatty acid desaturase 2 (FADS2) affects the pluripotency of hESCs by regulating energy metabolism., PMID:39756764
Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression., PMID:39737935
ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling., PMID:39696518
LINE-1-Induced Retrotransposition Affects Early Preimplantation Embryo DNA Integrity and Pluripotency., PMID:39684434
Reappraisal of soft tissue myoepithelial tumors by DNA methylation profiling reveals an epigenetically distinct group of mostly fusion-driven neoplasms., PMID:39636306
Resveratrol Can Differentiate Human Melanoma Stem-like Cells from Spheroids Treated With All-trans Retinoic Acid., PMID:39626925
[Oct4 promotes the progression and radioresistance of esophageal squamous cell carcinoma by regulating epithelial-mesenchymal transition]., PMID:39622734
Nicotinamide mononucleotide enhances the developmental potential of mouse early embryos exposed to perfluorooctanoic acid., PMID:39613165
Identification of methylation-sensitive human transcription factors using meSMiLE-seq., PMID:39605503
ELAVL1 governs breast cancer malignancy by regulating cell stemness., PMID:39603463
Impact of endogenous viral elements on glioma clinical phenotypes by inducing OCT4 in the host., PMID:39588508
Inhibition of lung tumorigenesis by transient reprogramming in cancer cells., PMID:39587064
Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signaling., PMID:39561779
The emergence of Sox and POU transcription factors predates the origins of animal stem cells., PMID:39543096
The efficacy of infrared diode laser in enhancing the regenerative potential of human periodontal ligament stem cells (hPDLSCs)., PMID:39472894
Loss in Pluripotency Markers in Mesenchymal Stem Cells upon Infection with Chlamydia trachomatis., PMID:39467689
Effects of Thyroid Hormones on Cellular Development in Human Ovarian Granulosa Tumor Cells (KGN)., PMID:39407059
A novel investigation of NANOG and POU5F1 associations in the pluripotent characterization of ES-like and epiblast cells., PMID:39406879
Rapamycin treatment during prolonged in vitro maturation enhances the developmental competence of immature porcine oocytes., PMID:39398303
For research use only. Not for human or drug use.
