Catalog No.
YHF89301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp553-Lys753
Predicted molecular weight
25.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01813
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Phosphofructo-1-kinase isozyme C, ATP-dependent 6-phosphofructokinase, platelet type, PFK-P, PFKF, ATP-PFK, PFKP, 6-phosphofructokinase type C, Phosphohexokinase, PFK-C
Molecular Subtyping Based on Hippocampal Cryptic Exon Burden Reveals Proteome-wide Changes Associated with TDP-43 Pathology across the Spectrum of LATE and Alzheimer's Disease., PMID:40501554
Ginsenoside Rb1 inhibits chronic stress-induced colorectal cancer via regulating glycolysis and β2-AR/CREB1 signaling pathway., PMID:40498670
Changes in Gene Transcription in Cumulus Cells from Women of Advanced Maternal Age under the Influence of Extracellular Vesicles from Follicular Fluid of Young Donors., PMID:40448879
Mitoquinol improves phagocytosis and glycolysis in ethanol-exposed macrophages via HIF-1α-PFKP axis., PMID:40356076
Integrating Bioinformatics and Machine Learning to Identify Glucose Metabolism-Related Biomarkers with Diagnostic and Prognostic Value for Patients with Kidney Renal Clear Cell Carcinoma., PMID:40341002
Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma., PMID:40307857
Asymmetric cell division of ALDH1-positive cancer stem cells generates glycolytic metabolically diverse cell populations., PMID:40263471
Rhythmic TDP-43 affects RNA splicing of USP13, resulting in alteration of BMAL1 ubiquitination., PMID:40202498
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis., PMID:40167953
DDIT4 participates in high glucose-induced fibroblast-like synoviocytes overactivation and cartilage injury by regulating glycolysis., PMID:40124471
Tanshinone IIA Suppresses the Proliferation of MGC803 Cells by Disrupting Glycolysis Under Anaerobic Conditions., PMID:40009338
Comments on "The mRNA and Protein Levels of the Glycolytic Enzymes Lactate Dehydrogenase A (LDHA) and Phosphofructokinase Platelet (PFKP) Are Good Predictors of Survival Time, Recurrence, and Risk of Death in Cervical Cancer Patients"., PMID:39980160
Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy., PMID:39807332
RNF123 inhibits cell viability, cell cycle and colony formation of breast cancer by inhibiting glycolysis via ubiquitination of PFKP., PMID:39725718
Momordicine-I suppresses head and neck cancer growth by modulating key metabolic pathways., PMID:39696286
PFKP silencing suppresses tumor growth via the AXL-MET axis., PMID:39664584
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα., PMID:39657538
PFKP Lactylation Promotes the Ovarian Cancer Progression Through Targeting PTEN., PMID:39638933
Integrative metabolomics and proteomics reveal the effect and mechanism of Zi Qi decoction on alleviating liver fibrosis., PMID:39578538
Screening of hub genes for sepsis-induced myopathy by weighted gene co-expression network analysis and protein-protein interaction network construction., PMID:39438952
PLOD1 promote proliferation and migration with glycolysis via the Wnt/β-catenin pathway in THCA., PMID:39424162
PFKP inhibition protects against pathological cardiac hypertrophy by regulating protein synthesis., PMID:39419453
Serinc2 Drives the Progression of Cervical Cancer Through Regulating Myc Pathway., PMID:39417376
Trim21 mediates metabolic reprogramming in renal tubular cells via PFKP ubiquitination to alleviate renal fibrosis., PMID:39308018
Suppression of ZEB1 by Ethyl caffeate attenuates renal fibrosis via switching glycolytic reprogramming., PMID:39270946
The novel HSP90 monoclonal antibody 9B8 ameliorates articular cartilage degeneration by inhibiting glycolysis via the HIF-1 signaling pathway., PMID:39229534
Phosphofructokinase-1 in Cancer: A Promising Target for Diagnosis and Therapy., PMID:39171598
A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression., PMID:38982480
Quercetin alleviates liver fibrosis via regulating glycolysis of liver sinusoidal endothelial cells and neutrophil infiltration., PMID:38943679
YTHDF2 regulates MSS51 expression contributing to mitochondria dysfunction of granulosa cells in polycystic ovarian syndrome patients., PMID:38830447
Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia., PMID:38750680
A Ratiometric Catalog of Protein Isoform Shifts in the Cardiac Fetal Gene Program., PMID:38645170
IL-6-Driven Autocrine Lactate Promotes Immune Escape of Uveal Melanoma., PMID:38551584
Identification and Analysis of Gene Biomarkers for Ovarian Cancer., PMID:38416665
HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer., PMID:38394204
Prediction of CAF-related genes in immunotherapy and drug sensitivity in hepatocellular carcinoma: a multi-database analysis., PMID:38233508
PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression., PMID:38217030
Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells., PMID:38155775
Harpagide inhibits the TNF-α-induced inflammatory response in rat articular chondrocytes by the glycolytic pathways for alleviating osteoarthritis., PMID:38142643
PFKP confers chemoresistance by upregulating ABCC2 transporter in non-small cell lung cancer., PMID:38090515
Inhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis., PMID:38086793
Synergistic suppressive effects on triple-negative breast cancer by the combination of JTC-801 and sodium oxamate., PMID:37970352
p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP., PMID:37967006
Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes., PMID:37956994
Hyperglycemia-induced miR182-5p drives glycolytic and angiogenic response in Proliferative Diabetic Retinopathy and RPE cells via depleting FoxO1., PMID:37952722
Biomarkers Assessing the Role of Cumulus Cells on IVF Outcomes: A Systematic Review., PMID:37947940
Comprehensive analysis of serum exosome-derived lncRNAs and mRNAs from patients with rheumatoid arthritis., PMID:37845777
FUNDC1/PFKP-mediated mitophagy induced by KD025 ameliorates cartilage degeneration in osteoarthritis., PMID:37838829
Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer., PMID:37835536
PFKP is a prospective prognostic, diagnostic, immunological and drug sensitivity predictor across pan-cancer., PMID:37833332
For research use only. Not for human or drug use.
