Catalog No.
YHF88701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys163
Predicted molecular weight
20.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01668
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calcium channel, L type, alpha-1 polypeptide, isoform 2, Voltage-gated calcium channel subunit alpha Cav1.3, Voltage-dependent L-type calcium channel subunit alpha-1D, CCHL1A2, CACNA1D, CACN4, CACNL1A2, CACH3
CACNA1D is a circadian gene and causes familial advanced sleep phase., PMID:40460120
Prevalence of KCNJ5 mutations in aldosterone-producing adenomas among Malaysian primary aldosteronism patients: Genotype-phenotype correlation., PMID:40302475
Heart Rate Mystery Unveiled: Sex Differences in Human Sinoatrial Node Genes and Female Tachycardia., PMID:40265247
Expression Patterns of Cav1.3 in the Developing Stria Vascularis of Sprague-Dawley Rats., PMID:40206018
Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional WFS1 variant., PMID:40202504
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups., PMID:40185092
Alectinib causes sinus bradycardia by suppressing L-type calcium current in sinus node., PMID:40118326
Advancing age and sex modulate antidyskinetic efficacy of striatal CaV1.3 gene therapy in a rat model of Parkinson's disease., PMID:40010015
The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer., PMID:39958978
CaV2.3 channels in the mouse central medial thalamic nucleus are essential for thalamocortical oscillations and spike wave discharges., PMID:39929891
CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells., PMID:39718549
Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading., PMID:39622224
Generation of an iPSC cell line (VANYHHi001-A) from a patient with cardiac arrythmias carrying CACNA1D, SCN5A, and DSP variants., PMID:39551029
Evolutionary Characteristics in Primary Aldosteronism Patients., PMID:39502033
Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors., PMID:39429164
Inactivation induced by pathogenic Cav1.3 L-type Ca2+-channel variants enhances sensitivity for dihydropyridine Ca2+ channel blockers., PMID:39370994
The L-type calcium channel CaV1.3: A potential target for cancer therapy., PMID:39365143
Association Study of CACNA1D, KCNJ11, KCNQ1, and CACNA1E Single-Nucleotide Polymorphisms with Type 2 Diabetes Mellitus., PMID:39273144
Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p., PMID:39236286
Upregulation of the Cav1.3 channel in inner hair cells by interleukin 6-dependent inflammaging contributes to age-related hearing loss., PMID:39148148
Voltage-gated ion channel's gene expression in the myocardium of embryo and adult chickens., PMID:39127438
CaM-dependent modulation of human CaV1.3 whole-cell and single-channel currents by C-terminal CaMKII phosphorylation site S1475., PMID:39037941
Environmental endocrine disrupting chemical 4-tert-butylphenol induced calcium overload and subsequent autophagy impairment via miRNA-363/CACNA1D Axis in epithelioma papulosum cyprini cells., PMID:38945384
Human Genetics of Ventricular Septal Defect., PMID:38884729
Molecular Specializations Underlying Phenotypic Differences in Inner Ear Hair Cells of Zebrafish and Mice., PMID:38826418
CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy., PMID:38783117
Genome-wide association analysis explores the genetic loci of amino acid content in duck's breast muscle., PMID:38755558
Unraveling the significance of PPP1R1A gene in pancreatic β-cell function: A study in INS-1 cells and human pancreatic islets., PMID:38574885
Pathogenicity of de novo CACNA1D Ca2+ channel variants predicted from sequence co-variation., PMID:38553610
Undiagnosed Disease Network collaborative approach in diagnosing rare disease in a patient with a mosaic CACNA1D variant., PMID:38511854
Association between CACNA1D polymorphisms and hypospadias in a southern Chinese population., PMID:38378373
Multifocal, Asymmetric Bilateral Primary Aldosteronism Cannot be Excluded by Strong Adrenal Vein Sampling Lateralization: An International Retrospective Cohort Study., PMID:38174562
Whole‑exome sequencing reveals Lewis lung carcinoma is a hypermutated Kras/Nras-mutant cancer with extensive regional mutation clusters in its genome., PMID:38167599
Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways., PMID:38007517
Biophysical properties of NaV1.5 channels from atrial-like and ventricular-like cardiomyocytes derived from human induced pluripotent stem cells., PMID:38001331
CACNA1D Gene Polymorphisms Associate With Increased Blood Pressure and Salt Sensitivity of Blood Pressure in White Individuals., PMID:37846579
Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons., PMID:37736859
The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice., PMID:37698939
Clear Cell Adenocarcinoma of Urethra: Clinical and Pathologic Implications and Characterization of Molecular Aberrations., PMID:37697729
Calcium-Activated Big-Conductance (BK) Potassium Channels Traffic through Nuclear Envelopes into Kinocilia in Ray Electrosensory Cells., PMID:37681857
Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs., PMID:37643467
Quinpirole inhibits levodopa-induced dyskinesias at structural and behavioral levels: Efficacy negated by co-administration of isradipine., PMID:37640098
Renzhu Ointment Regulates L-Type Voltage-Dependent Calcium Channel in Mice Model of Senna-Induced Diarrhea by Transdermal Administration., PMID:37588013
Only one beer can be mortal: a case report of two sisters with cardiac arrest due to a homozygous mutation in PPA2 gene., PMID:37269378
Lack of the transcription factor Nfix causes tachycardia in mice sinus node and rats neonatal cardiomyocytes., PMID:37186371
Effect of semaglutide and empagliflozin on cognitive function and hippocampal phosphoproteomic in obese mice., PMID:37007007
CACNA1D overexpression and voltage-gated calcium channels in prostate cancer during androgen deprivation., PMID:36949059
Genomic regulatory sequences in the pathogenesis of bipolar disorder., PMID:36824672
L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development., PMID:36803254
CACNA1D-Related Channelopathies: From Hypertension to Autism., PMID:36592224
For research use only. Not for human or drug use.
