Catalog No.
YHF88001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser293-Ala467
Predicted molecular weight
21.61 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01581
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hydroxymethylglutaryl-CoA synthase, cytoplasmic, 3-hydroxy-3-methylglutaryl coenzyme A synthase, HMG-CoA synthase, HMGCS1, HMGCS
Hypoxia-Induced Up-Regulation of ACSS2 Drives the PI3K/AKT/mTOR Pathway Through HMGCS1 to Enhance the Proliferation and Stemness of Pancreatic Cancer Cells., PMID:40485521
Mult-omics analysis reveals the lipid-lowering effects of sea buckthorn and milk thistle solid beverage in hyperlipidemic rats., PMID:40472616
Multi-omics unveils BCAA metabolism markers L-leucine and HMGCS1 as prognostic marker for immunotherapy efficacy in non-small cell lung cancer., PMID:40457349
Melatonin enhances the function of porcine immature Sertoli cells by inhibiting the HMGCS1-estradiol pathway., PMID:40413863
Mitochondrial Genome-Encoded lncND5 Regulates Mitophagy in Hypoxic Pulmonary Artery Smooth Muscle Cell., PMID:40364724
Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis., PMID:40349061
Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model., PMID:40330818
DCMS analysis revealed differential selection signatures in the transboundary Sahiwal cattle for major economic traits., PMID:40325078
Aqueous Polygalae Radix extract (PRE) prolongs the lifespan of C. elegans and alleviates D-galactose-induced oxidative stress in the mouse liver and brain by modulating PPARγ/MAPK., PMID:40287113
Transcriptional landscape and chromatin accessibility reveal key regulators for liver regenerative initiation and organoid formation., PMID:40286271
HKDC1 promotes ovarian cancer progression through boosting lipid metabolism and immune escape by stabilizing G6PC/G6PC2., PMID:40234623
m6A-induced DEAD-box RNA helicase 21 enhances lipid metabolism via 3‑hydroxy-3-methylglutaryl-CoA synthases 1 in colorectal cancer., PMID:40127603
Regulation of CNS Lipids by Protease Activated Receptor 1., PMID:40123504
Identification of Key Fatty Acid Metabolism-Related Genes in Alzheimer's Disease., PMID:40108056
High glucose levels promote glycolysis and cholesterol synthesis via ERRα and suppress the autophagy-lysosomal pathway in endometrial cancer., PMID:40097416
Genome-Wide Association Study Reveals Growth-Related SNPs and Candidate Genes in Largemouth Bass (Micropterus salmoides) Adapted to Hypertonic Environments., PMID:40076461
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production., PMID:39821719
Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex., PMID:39702571
Cepharanthine as an effective small cell lung cancer inhibitor: integrated insights from network pharmacology, RNA sequencing, and experimental validation., PMID:39669201
HMGCS1 variants cause rigid spine syndrome amenable to mevalonic acid treatment in an animal model., PMID:39531736
Transcriptome Analysis Reveals the Early Development in Subcutaneous Adipose Tissue of Laiwu Piglets., PMID:39457885
Detection of structural variants linked to mutton flavor and odor in two closely related black goat breeds., PMID:39425017
Identification of novel targets associated with cholesterol metabolism in nonalcoholic fatty liver disease: a comprehensive study using Mendelian randomization combined with transcriptome analysis., PMID:39359475
Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction., PMID:39235443
Regulation of cholesterol biosynthesis by CTCF and H3K27 methylation is critical for cell migration., PMID:39232451
Genomic analyses of intricate interaction of TE-lncRNA overlapping genes with miRNAs in human diseases., PMID:39215947
The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis., PMID:39119789
Leonurine Exerts Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Endometritis by Modulating Mouse JAK-STAT/PI3K-Akt/PPAR Signaling Pathways., PMID:39062636
BCL7A inhibits the progression and drug-resistance in acute myeloid leukemia., PMID:39053383
Profile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C., PMID:38997072
Targeting HMGCS1 restores chemotherapy sensitivity in acute myeloid leukemia., PMID:38994525
[Inhibition of Lung Squamous Cancer Target HMGCS1 Promotes Cellular Ferroptosis]., PMID:38880920
Gypenoside L inhibits hepatocellular carcinoma by targeting the SREBP2-HMGCS1 axis and enhancing immune response., PMID:38861912
The picky mTORC1 in metabolic enzyme degradation., PMID:38848689
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing., PMID:38811564
FOXA3 regulates cholesterol metabolism to compensate for low uptake during the progression of lung adenocarcinoma., PMID:38805565
mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway., PMID:38788716
A chemical probe to modulate human GID4 Pro/N-degron interactions., PMID:38773330
Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis., PMID:38608446
Key genes involved in nonalcoholic steatohepatitis improvement after bariatric surgery., PMID:38469144
circ_HMGCS1 modulates hepatocellular carcinoma chemoresistance via miR-338-5p/IL-7 pathway., PMID:38445791
The Complement Component 4 Binding Protein α Gene: A Versatile Immune Gene That Influences Lipid Metabolism in Bovine Mammary Epithelial Cell Lines., PMID:38397050
CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation., PMID:38308184
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway., PMID:38275129
Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms., PMID:38263056
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism., PMID:38172338
Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice., PMID:38086439
Human PBMCs Form Lipid Droplets in Response to Spike Proteins., PMID:38004695
Antiadipogenic Effect of Citrus Flavonoids: Evidence from RNA Sequencing Analysis and Activation of AMPK in 3T3-L1 Adipocytes., PMID:37955544
TMT-based quantitative proteomics reveals the targets of andrographolide on LPS-induced liver injury., PMID:37817228
For research use only. Not for human or drug use.
