Catalog No.
YHF87501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala19-Cys99
Predicted molecular weight
35.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01524
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Defensin, alpha 6, DEF6, Defensin-6, DEFA6
Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples., PMID:39738327
Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial Responses., PMID:39386684
Innate Immunity Activation in Newly Diagnosed Ileocolonic Crohn's Disease: A Cohort Study., PMID:38319717
FOXO inhibition rescues α-defensin expression in human intestinal organoids., PMID:37956278
Oat β-glucan supplementation pre- and during pregnancy alleviates fetal intestinal immunity development damaged by gestational diabetes in rats., PMID:37622658
Predicting diagnostic biomarkers associated with immune infiltration in Crohn's disease based on machine learning and bioinformatics., PMID:37496049
PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice., PMID:37030630
Paneth cell proteins DEFA6 and GUCA2A as tissue markers in necrotizing enterocolitis., PMID:37017768
Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation., PMID:36341397
Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding., PMID:35562899
Flagella at the Host-Microbe Interface: Key Functions Intersect With Redundant Responses., PMID:35401545
Human α-defensin 6 (HD6) suppresses CRC proliferation and metastasis through abolished EGF/EGFR signaling pathway., PMID:34975297
Protective Role of Spermidine in Colitis and Colon Carcinogenesis., PMID:34767785
Identification of diagnostic signatures in ulcerative colitis patients via bioinformatic analysis integrated with machine learning., PMID:34731452
IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity., PMID:33060802
NOD2 receptor is crucial for protecting against the digestive form of Chagas disease., PMID:32986710
An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease., PMID:32351509
Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy., PMID:32089753
Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer., PMID:30932884
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments., PMID:30808760
Autologous cell lines from circulating colon cancer cells captured from sequential liquid biopsies as model to study therapy-driven tumor changes., PMID:30374140
Cell adhesion properties of human defensins., PMID:29800568
Key Determinants of Human α-Defensin 5 and 6 for Enhancement of HIV Infectivity., PMID:28850095
Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing., PMID:28423004
Human α-Defensin 6: A Small Peptide That Self-Assembles and Protects the Host by Entangling Microbes., PMID:28296382
Disentangling Nanonets: Human α-Defensin 6 Targets Candida albicans Virulence., PMID:28198610
Human α-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans., PMID:28026958
Amyloid formation: functional friend or fearful foe?, PMID:27151743
Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue., PMID:27036372
Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease., PMID:26891258
Antimicrobial activity of human α-defensin 6 analogs: insights into the physico-chemical reasons behind weak bactericidal activity of HD6 in vitro., PMID:26400692
Regulation of human enteric α-defensins by NOD2 in the Paneth cell lineage., PMID:25433720
Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide., PMID:25354318
Molecular basis for self-assembly of a human host-defense peptide that entraps bacterial pathogens., PMID:25158166
Immunoprotective effect of epigallocatechin-3-gallate on oral anticancer drug-induced α-defensin reduction in Caco-2 cells., PMID:24583869
Suppression of antimicrobial peptide expression by ureaplasma species., PMID:24491573
Both group 4 capsule and lipopolysaccharide O-antigen contribute to enteropathogenic Escherichia coli resistance to human α-defensin 5., PMID:24324796
Macaque paneth cells express lymphoid chemokine CXCL13 and other antimicrobial peptides not previously described as expressed in intestinal crypts., PMID:23803902
Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case-control study for gastric cancer risk., PMID:23028900
Immunology. HD6 defensin nanonets., PMID:22837514
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets., PMID:22722251
Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases., PMID:22488912
Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease., PMID:22393312
Activation of REG family proteins in colitis., PMID:21992413
Innate immune environment in ileal pouch mucosa: α5 defensin up-regulation as predictor of chronic/relapsing pouchitis., PMID:21983950
Intestinal alpha-defensin expression in pediatric inflammatory bowel disease., PMID:21910169
Efficiency of antimicrobial defense: molecular flexibility of natural defensin and artificial bis-quaternary ammonium compound., PMID:21873175
Prognostic and predictive potential molecular biomarkers in colon cancer., PMID:21696062
Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment., PMID:21672195
Fibroblast growth factor receptor-3 (FGFR-3) regulates expression of paneth cell lineage-specific genes in intestinal epithelial cells through both TCF4/beta-catenin-dependent and -independent signaling pathways., PMID:21388956
For research use only. Not for human or drug use.
