Catalog No.
YHF85301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val264-Phe437
Predicted molecular weight
21.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01094
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Retinoblastoma-binding protein 3, Retinoblastoma-associated protein 1, RBBP-3, Transcription factor E2F1, RBBP3, E2F1, E2F-1, RBAP-1, pRB-binding protein E2F-1, PBR3
Bypassing the guardian: regulated cell death pathways in p53-mutant cancers., PMID:40517236
Identification of key genes in the liver of offspring from obesity maternal mice by bioinformatics analysis., PMID:40513071
The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells., PMID:40486678
Repurposing of PI3K inhibitors for high-grade serous ovarian cancer: A novel competing endogenous network analysis-based approach., PMID:40472506
Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes., PMID:40457435
Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition., PMID:40452017
In Silico Analysis Revealed a Role for NUSAP1 in Lung Adenocarcinoma through E2F1/hsa-let-7b-5p/lncRNA-TMPO-AS1., PMID:40439393
Transcription factor E2F1 promotes non-small cell lung cancer progression by activating the PI3K/AKT pathway through MCM4., PMID:40437556
Targeting EP300 in diffuse large b-cell lymphoma: efficacy of A485 and synergistic effects with XPO1 inhibition., PMID:40437414
The E2F1/SBK1 axis activates the Notch signaling pathway to accelerate the malignant progression of breast cancer., PMID:40423801
A previously uncharacterized role of TAp73 in ferroptosis by modulating oxidative homeostasis in cervical cancer., PMID:40409453
Protein Acetylation in Age-Related Macular Degeneration: Mechanisms, Roles, and Therapeutic Perspectives., PMID:40402519
Overexpression of FOXM1 drives mycosis fungoides progression by regulating the cell cycle., PMID:40368678
PSMD14/E2F1 Axis-Mediated CENPF Promotes the Metastasis of Triple-Negative Breast Cancer Through Inhibiting Ferroptosis., PMID:40365861
Ethanol extract from Ziziphus nummularia stem inhibits MCF-7 breast cancer cell proliferation through TP53 regulating kinase (TP53RK)-mediated p53 activation: In silico and genes expression investigations., PMID:40352177
Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAM., PMID:40319068
Effective targeting of E2F1 transcription factor via siRNA gene electrotransfer in HT-29 colorectal carcinoma xenografts., PMID:40311353
LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression., PMID:40279246
Blocking PSMD14-mediated E2F1/ERK/AKT signaling pathways suppresses the progression of anaplastic thyroid cancer., PMID:40262717
Role of the cell cycle-related gene cdk2 and its associated ceRNA network in sexual size dimorphism of Cynoglossus semilaevis., PMID:40250729
NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming., PMID:40246825
Clinical Outcomes and Genomic Alterations in Gleason Score 10 Prostate Cancer., PMID:40227503
In Silico Identification of ANKRD22 as a Theragnostic Target for Pancreatic Cancer and Fostamatinib's Therapeutic Potential., PMID:40225855
E2F1-driven EXOSC10 transcription promotes hepatocellular carcinoma growth and stemness: a potential therapeutic target., PMID:40221814
Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells., PMID:40215234
The acidic microenvironment promotes pancreatic cancer progression via the lncRNA-LOC100507424/E2F1/FOXM1 axis., PMID:40211195
ECPPF stratification identifies occult high-risk subgroups in stage I, grade 1 or 2, ≤50 % invasive endometrial cancer: Candidates for adjuvant therapy., PMID:40199195
BUB1, miR-495-3p, and E2F1/E2F8 axis is associated with poor prognosis of breast cancer patients and infiltration of Th2 cells in the tumor microenvironment., PMID:40183319
Computational molecular insights into ibrutinib as a potent inhibitor of HER2-L755S mutant in breast cancer: gene expression studies, virtual screening, docking, and molecular dynamics analysis., PMID:40177517
Multiomic traits reveal that critical irinotecan-related core regulator FSTL3 promotes CRC progression and affects ferroptosis., PMID:40140870
DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair., PMID:40117291
Case Report and Literature Review: Overexpression of HMGA in Concomitant Plurihormonal Tumor and Papillary Thyroid Carcinoma., PMID:40114328
Metabolomics Analysis of Functional Activity Changes in Residual Tumour Cells After IOCS Treatment., PMID:40111872
Apolipoprotein C1 and apoprotein E as potential therapeutic and prognostic targets for adrenocortical carcinoma., PMID:40109215
Minichromosome maintenance 4 plays a key role in protecting against acute kidney injury by regulating tubular epithelial cells survival and regeneration., PMID:40107353
Integrative analyses of circulating microRNA expression profile in hexavalent chromium exposed workers - A cross-sectional study within the SafeChrom project., PMID:40098212
Drug-likeness evaluation and inhibitory mechanism of the emodin derivative on cardiac fibrosis based on metastasis-associated protein 3., PMID:40083252
Long Noncoding RNA E2F1 Messenger RNA Stabilizing Factor (EMS) Promotes Sorafenib Resistance in Renal Cell Carcinoma by Regulating miR-363-3p and Dual-Specificity Phosphatase 10 Expression., PMID:40067251
DPHC from Alpinia officinarum Hance specifically modulates the function of CENPU in the cell cycle and apoptosis to ameliorate hepatocellular carcinoma., PMID:40058474
SLC7A5/E2F1/PTBP1/PKM2 axis mediates progression and therapy effect of triple-negative breast cancer through the crosstalk of amino acid metabolism and glycolysis pathway., PMID:40054655
Cdk1 and PP2A constitute a molecular switch controlling orderly degradation of atypical E2Fs., PMID:40027684
E2F transcription factor 1 as a potential prognostic biomarker and promotes tumor proliferation in skin cutaneous melanoma., PMID:40023140
Centromere protein U mediates the ubiquitination and degradation of RPS3 to facilitate temozolomide resistance in glioblastoma., PMID:40023134
E2F1 activates USP19 to affect the stability of c-Myc to facilitate the progression of hepatocellular carcinoma., PMID:40020513
Targeting TUBG1 in RB1-negative tumors., PMID:40019206
Atlas of expression of acyl CoA binding protein/diazepam binding inhibitor (ACBP/DBI) in human and mouse., PMID:40011442
MCM8 promotes NR4A1-mediated E2F1 transcription and facilitates renal cell carcinoma through enhancing aerobic glycolysis., PMID:39992472
NCAPH Promotes the Proliferation of Prostate Cancer Cells Via Modulating the E2F1 Mediated PI3K/AKT/mTOR Axis., PMID:39991770
KAT8 facilitates the proliferation of cancer cells through enhancing E7 function in HPV-associated cervical cancer., PMID:39989021
VRK2 promotes colorectal cancer growth and impedes immunotherapy and 5-FU treatment efficacy., PMID:39978443
For research use only. Not for human or drug use.
