Catalog No.
YHF84501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn3-Pro491
Predicted molecular weight
57.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q00987
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MDM2, Hdm2, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2, RING-type E3 ubiquitin transferase Mdm2, Double minute 2 protein, Oncoprotein Mdm2
Tumor-derived CXCL5 promotes 5-fluorouracil resistance in colorectal cancer cells via p21 downregulation., PMID:40514583
Resolving spatial subclonal genomic heterogeneity of loss of heterozygosity and extrachromosomal DNA in gliomas., PMID:40514380
The Intrabody Against Murine Double Minute 2 via a p53-Dependent Pathway Induces Apoptosis of Cancer Cell., PMID:40508092
Simple Transgene Overexpression using Scallop Hemocyte Culture Platform Enables Functional Genetic Research in Molluscs., PMID:40498244
Exploring the anti-gastric cancer mechanisms of Diosgenin through integrated network analysis, bioinformatics, single-cell sequencing, and cell experiments., PMID:40487391
Identification of MDM4 as a Prognostic Biomarker and a Target for Therapeutics in Colorectal Cancer., PMID:40485064
Marine natural product Methyl mycophenolate inhibits gastric cancer growth through regulating p53 and the downstream pathways., PMID:40484944
Glycyrrhizic acid mitigates hepatocyte steatosis and inflammation through ACE2 stabilization via dual modulation of AMPK activation and MDM2 inhibition., PMID:40484334
Gobal crotonylome reveals that HNRNPC and its crotonylation promote p53-deficient tumor growth by stabilizing CCND1 and MCM3 mRNAs., PMID:40482911
Interplay between G protein-biased and arrestin-biased pathways in 5-HT2AR-mediated ERK activation., PMID:40473228
Lipid Droplet-Organized MDM2-Mediated P53 Degradation: A Metabolic Switch Governing Diet-Driven Tumor Progression., PMID:40470795
Computational and Molecular Profiling of the Anticancer Properties of Thuja occidentalis L. From Southern Punjab., PMID:40468803
Real-world survival outcomes and MDM2 prevalence in US patients with metastatic dedifferentiated liposarcoma., PMID:40468683
MDM2 inhibitors in sarcomas: results and next steps., PMID:40464483
PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation manner., PMID:40462177
AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition., PMID:40461512
Discovery of indane and naphthalene derivatives as USP7 inhibitors., PMID:40460722
APG-115 synergizes with bortezomib to induce apoptosis in cervical cancer cells., PMID:40455647
Targeted Degradation of Mutant p53 Reverses the Pro-oncogenic Dominant-Negative Effect., PMID:40452346
Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition., PMID:40452017
CHD1L in cancer and beyond: structure, oncogenic functions, and therapeutic potential., PMID:40442742
Characterization of a dual degrader of MDM2 and GSPT1., PMID:40440791
Association of Insertion/Deletion Polymorphisms of MDM2, MCP-1 and VEGF with Esophageal Cancer Risk in North-West Indians: A Case - Control Study., PMID:40439374
20-Hydroxyecdysone Modulates Bmp53-Mediated Apoptosis Regulation by Suppressing Mdm2-like-Dependent Ubiquitination in Silkworm, Bombyx mori., PMID:40429257
Mechanistic Role of the Mdm2/MdmX Lid Domain in Regulating Their Interactions with p53., PMID:40427535
The Central Role of Ribosomal Proteins in p53 Regulation., PMID:40427096
Molecular Targets and Mechanisms of Piperine Against Breast Cancer: A Network Pharmacology, Molecular Docking Analysis, and Toxicity Prediction., PMID:40424641
The Impact of METTL3 on MDM2 Promotes Podocytes Injury During Diabetic Kidney Disease., PMID:40421968
MDM2 as a therapeutic target in advanced biliary tract cancers., PMID:40421959
Defining short linear motif binding determinants by phage display-based deep mutational scanning., PMID:40411416
Regulation of the MDM2-p53 Nexus by a Nuclear Phosphoinositide and Small Heat Shock Protein Complex., PMID:40406464
Exosomal lncRNA profiles in patients with HFrEF: Evidence for KLF3-AS1 as a novel diagnostic biomarker., PMID:40404068
Cyclic peptide structure prediction and design using AlphaFold2., PMID:40399308
Identification of Potent Cell Penetrating, Nontoxic Peptides for Inhibiting MDM2-p53 Interactions: Characterization of Anticancer Peptides via Molecular Dynamics Simulations., PMID:40396628
Gelsolin's Protective Role in MASH through F-Actin Regulation and P53 Degradation., PMID:40390546
Reengineering of a Proteomimetic Pan-Ras Inhibitor into a Ras Degrader., PMID:40390192
Epstein-Barr virus nuclear antigen 1 (EBNA1) increases the expression levels of MDM2 and MDM4 genes in HeLa cells: a review on MDM2 and MDM4 roles in cancer., PMID:40382619
3'UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells., PMID:40381037
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target., PMID:40378836
Antibacterial Activity of the p53 Tumor Suppressor Protein-How Strong Is the Evidence?, PMID:40362653
Inorganic Arsenic Induces Elevated p53 Levels with Altered Functionality Impacting the Expression of Toll-like Receptor 3 and Other Target Genes in Immortalized Prostate Epithelial Cells., PMID:40362489
Unraveling Venetoclax Resistance: Navigating the Future of HMA/Venetoclax-Refractory AML in the Molecular Era., PMID:40361510
Effects of n-Myc and c-Myc on the expression of p53 family members and their transcriptional targets in human neuroblastoma cells., PMID:40349458
Mechanism of Rabdosia rubescens extract against gastric cancer microenvironment by SIRT1/NF-κB/p53 pathway and promoting tumor-associated macrophage polarization., PMID:40345273
Anti-cancer activity elucidation of geissolosimine as an MDM2-p53 interaction inhibitor: An in-silico study., PMID:40339040
HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson's Disease., PMID:40338442
Recurrent MDM2 Amplification in the Spectrum of HMGA2-Altered Pleomorphic Adenoma, Atypical Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma., PMID:40338436
Surgery/anesthesia may cause monocytes to promote tumor development., PMID:40335909
Assessing phototoxic drug properties of hydrochlorothiazide using human skin biopsies., PMID:40328921
Synergistic Activity of Combined FLT3-ITD and MDM2 Inhibition With Quizartinib and Milademetan in FLT3-ITD Mutant/TP53 Wild Type Acute Myeloid Leukemias., PMID:40327322
For research use only. Not for human or drug use.
