Catalog No.
YHF84401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Val393
Predicted molecular weight
46.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q00978
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interferon regulatory factor 9, ISGF3G, IRF-9, ISGF-3 gamma, ISGF3 p48 subunit, Transcriptional regulator ISGF3 subunit gamma, IRF9, Interferon-stimulated gene factor 3 gamma, IFN-alpha-responsive transcription factor subunit
IRF8 facilitates bovine ephemeral fever virus replication by downregulating IRF9., PMID:40513519
The viral early protein 4 of human papillomavirus type 16 suppresses innate antiviral immunity., PMID:40409624
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity., PMID:40330484
Chasing Virus Replication and Infection: PAMP-PRR Interaction Drives Type I Interferon Production, Which in Turn Activates ISG Expression and ISGylation., PMID:40284971
Human papillomavirus E2 proteins suppress innate antiviral signaling pathways., PMID:40264759
METTL3 depletion blocks vesicular stomatitis virus replication in pancreatic cancer cells through the establishment of an intrinsic antiviral state., PMID:40214229
Proteome profiling of the lung tissues of the mice co-infected with H9N2 influenza A virus and Pseudomonas aeruginosa., PMID:40187293
The critical role of the ZBP1-NINJ1 axis and IRF1/IRF9 in ethanol-induced cell death, PANoptosis, and alcohol-associated liver disease., PMID:40161842
Identification of a type I IFN- and IRF-inducible enhancer in the 5'-UTR intron of MAVS in large yellow croaker Larimichthys crocea., PMID:40020953
Cytoplasmic Shift of Interferon Regulatory Factors Co-Evolved With Jawed Vertebrate Innate Immunity., PMID:39977406
Identification and validation of diagnostic genes IFI44 and IRF9 in insomnia-associated autoimmune uveitis., PMID:39958336
Bioinformatics analysis and validation of novel biomarkers and competitive endogenous RNA networks involved in pyroptosis in diabetic nephropathy., PMID:39953123
Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons., PMID:39916981
FAM210B activates STAT1/IRF9/IFIT3 axis by upregulating IFN-α/β expression to impede the progression of lung adenocarcinoma., PMID:39900908
Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway., PMID:39781465
FAT1 knockdown enhances the CSC properties of HNSCC through p-CaMKII-mediated inactivation of the IFN pathway., PMID:39781458
Uncovering selection pressures on the IRF gene family in bats' immune system., PMID:39776231
LPS Disrupts Endometrial Receptivity by Inhibiting STAT1 Phosphorylation in Sheep., PMID:39769435
Genome-wide analysis of abnormal splicing regulators and alternative splicing involved in immune regulation in systemic lupus erythematosus., PMID:39743791
SARS-CoV-2 S protein disrupts the formation of ISGF3 complex through conserved S2 subunit to antagonize type I interferon response., PMID:39699185
Activation of cellular responses by cyclic dinucleotides and porphyromonas gingivalis lipopolysaccharide: a proteomic study on gingival fibroblasts., PMID:39669221
Association study of the JAK/STAT signaling pathway with susceptibility to COVID-19 in moroccan patient and in-silico analysis of rare variants., PMID:39647533
Genome-wide CRISPR screen reveals specific role of type I interferon signaling pathway in Newcastle disease virus establishment of persistent infection., PMID:39642411
Interferon Regulatory Factors (IRF1, IRF4, IRF5, IRF7 and IRF9) in Sichuan taimen (Hucho bleekeri): Identification and Functional Characterization., PMID:39596618
Weighted Gene Co-Expression Network Based on Transcriptomics: Unravelling the Differentiation Dynamics of 3T3-L1 Preadipocytes and the Regulatory Mechanism of Protopanaxatriol., PMID:39596321
Integrin β8 Facilitates Macrophage Infiltration and Polarization by Regulating CCL5 to Promote LUAD Progression., PMID:39535362
Exploring susceptibility and therapeutic targets for kidney stones through proteome-wide Mendelian randomization., PMID:39530187
TGFB2 mRNA Levels Prognostically Interact with Interferon-Alpha Receptor Activation of IRF9 and IFI27, and an Immune Checkpoint LGALS9 to Impact Overall Survival in Pancreatic Ductal Adenocarcinoma., PMID:39457004
Elucidating the role of PPARG inhibition in enhancing MERS virus immune response: A network pharmacology and computational drug discovery., PMID:39437592
Regulation of versican expression in macrophages is mediated by canonical type I interferon signaling via ISGF3., PMID:39400584
Lnc-LINC00511 promotes gastric cancer progression by regulating MiR-29c-3p/TRIP13 axis through AKT/mTOR pathway., PMID:39389496
Type I Interferonopathy among Non-Elderly Female Patients with Post-Acute Sequelae of COVID-19., PMID:39339845
Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer., PMID:39329063
A sensitive assay for measuring whole-blood responses to type I IFNs., PMID:39312669
Geniposide attenuates influenza virus-induced pneumonia by regulating inflammatory cytokines production. Evidences to elucidate the followed pathway., PMID:39303507
IRF9 and STAT1 as biomarkers involved in T-cell immunity in atherosclerosis., PMID:39234946
[Myxovirus resistance protein A (MxA) induces the expression of interferon-stimulated genes in HepG2 cells by enhancing the activity of the interferon-stimulated response element (ISRE)]., PMID:39215668
Transcriptomic response of lumpfish (Cyclopterus lumpus) head kidney to viral mimic, with a focus on the interferon regulatory factor family., PMID:39211041
P53 Status Influences the Anti-proliferative Effect Induced by IFITM1 Inhibition in Estrogen Receptor-positive Breast Cancer Cells., PMID:39191497
Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint blockade., PMID:39187481
IFNh and IRF9 influence the transcription of MHCII mediated by IFNγ to maintain immune balance in sea perch lateolabrax japonicus., PMID:39182707
Knockout of the WD40 domain of ATG16L1 enhances foot and mouth disease virus replication., PMID:39179961
Role and mechanism of IRF9 in promoting the progression of rheumatoid arthritis by regulating macrophage polarization via PSMA5., PMID:39170377
Cell-specific gene networks and drivers in rheumatoid arthritis synovial tissues., PMID:39161769
Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling., PMID:39110744
Increased Thyroid Hormone Action Alleviates Hippocampal Damage by Downregulating Neuronal Type I Interferon Signaling/Necroptosis in Diabetes-Associated Cognitive Dysfunction., PMID:39104259
Construction of an IFNAR1 knockout MDBK cell line using CRISPR/Cas9 and its effect on bovine virus replication., PMID:39100665
The Role of IRF9 Upregulation in Modulating Sensitivity to Olaparib and Platinum-Based Chemotherapies in Breast Cancer., PMID:39062738
In-silico discovery of common molecular signatures for which SARS-CoV-2 infections and lung diseases stimulate each other, and drug repurposing., PMID:39024368
Sangju Cold Granule exerts anti-viral and anti-inflammatory activities against influenza A virus in vitro and in vivo., PMID:38969152
For research use only. Not for human or drug use.
