Catalog No.
YHF75601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly2-Phe193
Predicted molecular weight
24.61 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P84074
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neuron-specific calcium-binding protein hippocalcin, BDR2, HPCA, Calcium-binding protein BDR-2
Protective effect of Tat fused HPCA protein on neuronal cell death caused by ischemic injury., PMID:38192804
MicroRNA-24-3p regulates neuronal differentiation by controlling hippocalcin expression., PMID:31486848
Perturbed Ca2+-dependent signaling of DYT2 hippocalcin mutant as mechanism of autosomal recessive dystonia., PMID:31301343
Delineating the phenotype of autosomal-recessive HPCA mutations: Not only isolated dystonia!, PMID:30991467
Proteomic identification of hippocalcin and its protective role in heatstroke-induced hypothalamic injury in mice., PMID:30256386
HPCA confirmed as a genetic cause of DYT2-like dystonia phenotype., PMID:30145809
Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia., PMID:28398555
DYT2 screening in early-onset isolated dystonia., PMID:27771228
HPCA-related dystonia: Too rare to be found?, PMID:27145302
Single-column purification of the tag-free, recombinant form of the neuronal calcium sensor protein, hippocalcin expressed in Escherichia coli., PMID:27001424
The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels., PMID:26958886
Long time remodeling during retinal degeneration evaluated by optical coherence tomography, immunocytochemistry and fundus autofluorescence., PMID:26521765
Mutations in HPCA cause autosomal-recessive primary isolated dystonia., PMID:25799108
Anesthetic sevoflurane reduces levels of hippocalcin and postsynaptic density protein 95., PMID:24870966
¹H, ¹³C, and ¹⁵N chemical shift assignments of neuronal calcium sensor protein, hippocalcin., PMID:23250791
Expression profiling shows differential molecular pathways and provides potential new diagnostic biomarkers for colorectal serrated adenocarcinoma., PMID:22696308
Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury., PMID:22639951
A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents., PMID:22544757
Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons., PMID:19686238
Hippocalcin functions as a calcium sensor in hippocampal LTD., PMID:16102532
Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory., PMID:15878804
Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population., PMID:15834280
Hippocalcin protects against caspase-12-induced and age-dependent neuronal degeneration., PMID:15607944
Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling., PMID:15336960
Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells., PMID:14638856
Residues within the myristoylation motif determine intracellular targeting of the neuronal Ca2+ sensor protein KChIP1 to post-ER transport vesicles and traffic of Kv4 K+ channels., PMID:14600268
Role of myristoylation in the intracellular targeting of neuronal calcium sensor (NCS) proteins., PMID:14505460
Brain region-specific changes in the expression of calcium sensor proteins after repeated applications of ketamine to rats., PMID:12614903
Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons., PMID:12445469
Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction., PMID:11836243
Role of hippocalcin in Ca2+ -induced activation of phospholipase D., PMID:11211872
Regulation of G protein-coupled receptor kinase subtypes by calcium sensor proteins., PMID:11108955
NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways., PMID:10899114
Age-related changes in expression of hippocalcin and NVP2 in rat brain., PMID:10344594
Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes., PMID:9931466
DNA regions supporting hippocalcin gene expression in cell lines., PMID:9495555
Characterization of the rat hippocalcin gene: the 5' flanking region directs expression to the hippocampus., PMID:8938744
Hippocalcin in rat retina. Comparison with calbindin-D28k, calretinin and neurocalcin., PMID:7789406
Hippocalcin expression in the brain of the Snell dwarf mutant mouse., PMID:7882001
Expression of hippocalcin in the developing rat brain., PMID:7955346
Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene., PMID:8166736
Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties., PMID:8360179
Hippocalcin: a calcium-binding protein of the EF-hand superfamily dominantly expressed in the hippocampus., PMID:8264990
Distribution of hippocalcin mRNA and immunoreactivity in rat brain., PMID:8233019
Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus., PMID:1280427
Isolation and characterization of recoverin-like Ca(2+)-binding protein from rat brain., PMID:1543495
Identification of recoverin-like immunoreactivity in mouse brain., PMID:1535270
For research use only. Not for human or drug use.
