Catalog No.
YHF68401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe165-Val379
Predicted molecular weight
26.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P78508
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATP-dependent inwardly rectifying potassium channel Kir4.1, KCNJ10, ATP-sensitive inward rectifier potassium channel 10, Inward rectifier K(+) channel Kir1.2, Potassium channel, inwardly rectifying subfamily J member 10
Astroglial Kir4.1 and AQP4 Channels: Key Regulators of Potassium Homeostasis and Their Implications in Autism Spectrum Disorders., PMID:40498219
Glial inwardly rectifying potassium channel 4.1 regulates secretion of BDNF and GDNF via ERK1/2 MAP kinases in trigeminal neuropathic pain., PMID:40456346
Potassium homeostasis during disease progression of Alzheimer's disease., PMID:40366190
Kir4.1/Kir5.1 of distal convoluted tubule is required for short-term angiotensin-II-induced stimulation of Na-Cl cotransporter., PMID:40241495
Effects of potassium on laryngeal-induced swallowing rate in rats., PMID:40178944
Association of Voltage-Gated Potassium Channel Polymorphisms with the Risk and Prognosis of Epilepsy in the Saudi Population: A Case-Control Study., PMID:40142207
Intracellular pH regulates the strength of the intrinsic inward rectification of Kir4.1/Kir5.1 channels., PMID:40133722
Unveiling Ketamine's Influence on Astrocytic Kir4.1 Channels Through Multimodal Analysis: Confocal Microscopy, Immunocytochemistry, Fluorescence Analysis, and Electrophysiology., PMID:40111612
Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels., PMID:40074079
Kir4.1 channel and voltage-gated calcium channel of astrocyte account for the transition dynamics of seizures., PMID:40024363
Preclinical Insights into the Role of Kir4.1 in Chronic Pain and Depression: Mechanisms and Therapeutic Potential., PMID:40001468
Astrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain., PMID:39951378
Regional Alterations in Müller Cell Protein Expression in Human and a Rat Model of Geographic Atrophy., PMID:39918478
Respiratory surveillance and inward rectifier potassium channel expression in lung tissue within an experimental epilepsy model., PMID:39864576
The Impact of Astroglia Kir4.1 Channel Dysfunction on Neuronal Activity and Autism-Related Behavioral Abnormalities., PMID:39834183
Kir4.1 and Aqp4 Contribution to Schisis Cystic Water Accumulation and Clearance in the Rs1 Exon-1 Del XLRS Rat Model., PMID:39766850
Kir5.1 regulates Kir4.2 expression and is a key component of the 50-pS inwardly rectifying potassium channel in basolateral membrane of mouse proximal tubules., PMID:39745541
Acteoside relieves diabetic retinopathy through the inhibition of Müller cell reactive hyperplasia by regulating TXNIP and mediating Kir4.1 channels in a PI3K/Akt-dependent manner., PMID:39689088
Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50., PMID:39680434
Expanding the genotypic and phenotypic spectrum of EAST/SeSAME syndrome: identification of a novel homozygous mutation (c.194 G > A) in KCNJ10 gene., PMID:39607615
Astrocytic proteins involved in regulation of the extracellular environment are increased in the Alzheimer's disease middle temporal gyrus., PMID:39603277
Heterozygous KCNJ10 Variants Affecting Kir4.1 Channel Cause Paroxysmal Kinesigenic Dyskinesia., PMID:39367724
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets., PMID:39276178
AQP4- and Kir4.1-Mediated Müller Cell Oedema Is Involved in Retinal Injury Induced By Hypobaric Hypoxia., PMID:39060906
Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway., PMID:38992988
Heterozygous Variants in KCNJ10 Cause Paroxysmal Kinesigenic Dyskinesia Via Haploinsufficiency., PMID:38979912
Astrocytes Modulate a Specific Paraventricular Thalamus→Prefrontal Cortex Projection to Enhance Consciousness Recovery from Anesthesia., PMID:38926088
Cytokine Levels in Experimental Branch Retinal Vein Occlusion Treated With Either Bevacizumab or Triamcinolone Acetonide., PMID:38899953
Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2., PMID:38886379
Do oligodendrocytes regulate axonal glucose uptake and consumption?, PMID:38866601
LRRC8/VRAC volume-regulated anion channels are crucial for hearing., PMID:38838775
Incomplete partition type II in its various manifestations: isolated, in association with EVA, syndromic, and beyond; a multicentre international study., PMID:38833161
Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50., PMID:38826427
Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model., PMID:38678030
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis., PMID:38530364
Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration., PMID:38462589
Rare Missense Variants in KCNJ10 Are Associated with Paroxysmal Kinesigenic Dyskinesia., PMID:38436103
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses., PMID:38355723
Transgenic Tg(Kcnj10-ZsGreen) fluorescent reporter mice allow visualization of intermediate cells in the stria vascularis., PMID:38321040
Genetic predisposition to differentiated thyroid cancer in the Polish population., PMID:38165228
Coexistence of temporal lobe epilepsy and idiopathic generalized epilepsy., PMID:38160579
Genetic Discrimination of Grade 3 and Grade 4 Gliomas by Artificial Neural Network., PMID:38150033
Satellite glial GPR37L1 regulates maresin and potassium channel signaling for pain control., PMID:38106084
Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity., PMID:38032389
Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na+ Channel (ENaC)., PMID:37909221
Generalized myokymia, or neuromyotonia, or both in dogs with or without spinocerebellar ataxia., PMID:37905444
Transgenic Tg(Kcnj10-ZsGreen) Fluorescent Reporter Mice Allow Visualization of Intermediate Cells in the Stria Vascularis., PMID:37886521
Emerging Mechanisms in the Pathogenesis of Menière's Disease: Evidence for the Involvement of Ion Homeostatic or Blood-Labyrinthine Barrier Dysfunction in Human Temporal Bones., PMID:37733989
Single-cell RNA-sequencing of stria vascularis cells in the adult Slc26a4-/- mouse., PMID:37322474
The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity., PMID:37126448
For research use only. Not for human or drug use.
