Catalog No.
YHF68201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser367
Predicted molecular weight
64.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P78426
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Homeobox protein Nkx-6.1, Homeobox protein NK-6 homolog A, NKX6A, NKX6-1
Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway., PMID:40365319
AG73-GelMA/AlgMA hydrogels provide a stable microenvironment for the generation of pancreatic progenitor organoids., PMID:40016740
Type 1 Diabetes Risk Variants Reduce Beta Cell Function., PMID:40004501
Recent advances in pancreatic α-cell transdifferentiation for diabetes therapy., PMID:39911402
Shh signaling directs dorsal ventral patterning in the regenerating X. tropicalis spinal cord., PMID:39855590
Pancreatic expression of CPT1A is essential for whole body glucose homeostasis by supporting glucose-stimulated insulin secretion., PMID:39814231
Sex-specific astrocyte regulation of spinal motor circuits by Nkx6.1., PMID:39731735
Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch., PMID:39696686
Development of MXene Composite Nanofiber-Based 3D Culture System for the Efficient Generation of MSC-Derived Functional Pancreatic β-Cells., PMID:39593212
A small molecule K-3 promotes PDX1 expression and potentiates the differentiation of pluripotent stem cells into insulin-producing pancreatic β cells., PMID:39556137
A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA., PMID:39532884
Effect of isoproterenol, a β-adrenergic agonist, on the differentiation of insulin-producing pancreatic β cells derived from human pluripotent stem cells., PMID:39461404
Dual PPAR-α/γ enhances beta cell identity, preserving islet structure in HF-fed mice., PMID:39437175
Transcriptional coactivator MED15 is required for beta cell maturation., PMID:39379383
From iPSCs to Pancreatic β Cells: Unveiling Molecular Pathways and Enhancements with Vitamin C and Retinoic Acid in Diabetes Research., PMID:39273600
A capsule-based scaffold incorporating decellularized extracellular matrix and curcumin for islet beta cell therapy in type 1 diabetes mellitus., PMID:39255833
MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants., PMID:39201476
MIR124-3 and NKX6-1 hypermethylation profiles accurately predict metachronous gastric lesions in a Caucasian population., PMID:39169394
Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitors., PMID:39080045
Identifying the regulatory network of microRNAs and mRNAs to clarify molecular mechanisms in stroke by bioinformatics analysis., PMID:38848199
Low concentrations of saracatinib promote definitive endoderm differentiation through inhibition of FAK-YAP signaling axis., PMID:38816763
Expression of Pfkfb isoenzymes during in vitro differentiation of mouse embryonic stem cells into insulin-producing cells., PMID:38813509
The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells., PMID:38698488
MAGIK: A rapid and efficient method to create lineage-specific reporters in human pluripotent stem cells., PMID:38579711
Combined DNA Methylation and Gastric Microbiome Marker Predicts Helicobacter pylori-Negative Gastric Cancer., PMID:38509701
CEBPA Overexpression Enhances β-Cell Proliferation and Survival., PMID:38392328
Preconditioning of human umbilical cord mesenchymal stem cells with deferoxamine potentiates the capacity of the secretome released from the cells and promotes immunomodulation and beta cell regeneration in a rat model of type 1 diabetes., PMID:38340421
Osteocalcin protects islet identity in low-density lipoprotein receptor knockout mice on high-fat diet., PMID:38305305
LINC MIR503HG Controls SC-β Cell Differentiation and Insulin Production by Targeting CDH1 and HES1., PMID:38243869
Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity., PMID:38237895
Silencing hsa_circ_0032449 inhibits the pancreatic differentiation of human embryonic stem cells via the hsa_miR-195-5p/CCND1/PI3K/AKT signaling pathway., PMID:38072304
Elucidation of the anti-β-cell dedifferentiation mechanism of a modified Da Chaihu Decoction by an integrative approach of network pharmacology and experimental verification., PMID:38007164
PPY-cell hyperplasia accompanying NENs: Immunohistochemical and nuclear medicine analysis., PMID:38000200
A simple tool for the synchronous differentiation of human induced pluripotent stem cells into pancreatic progenitors., PMID:37955342
Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice., PMID:37945756
AT7867 promotes pancreatic progenitor differentiation of human iPSCs., PMID:37922913
Restored UBE2C expression in islets promotes β-cell regeneration in mice by ubiquitinating PER1., PMID:37486389
The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling., PMID:37452039
Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells., PMID:37441495
Utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy., PMID:37305047
Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model., PMID:37248264
Efficient knock-in method enabling lineage tracing in zebrafish., PMID:36878640
Nanoparticle-mediated CRISPR/dCas9a activation of multiple transcription factors to engineer insulin-producing cells., PMID:36789698
p53 Inhibition in Pancreatic Progenitors Enhances the Differentiation of Human Pluripotent Stem Cells into Pancreatic β-Cells., PMID:36707464
Deficiency of transcription factor Nkx6.1 does not prevent insulin secretion in INS-1E cells., PMID:36639413
The Genetic Spectrum of Maturity-Onset Diabetes of the Young (MODY) in Qatar, a Population-Based Study., PMID:36613572
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas., PMID:36471070
2D and 3D cultured human umbilical cord-derived mesenchymal stem cell-conditioned medium has a dual effect in type 1 diabetes model in rats: immunomodulation and beta-cell regeneration., PMID:36451229
Single-cell RNA-seq transcriptomic landscape of human and mouse islets and pathological alterations of diabetes., PMID:36339258
An artificial LAMA2-GelMA hydrogel microenvironment for the development of pancreatic endocrine progenitors., PMID:36334352
For research use only. Not for human or drug use.
