Catalog No.
YHF66301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Met488
Predicted molecular weight
54.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P78371
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CCT2, CCT-beta, T-complex protein 1 subunit beta, 99D8.1, CCTB, TCP-1-beta
Small Extracellular Vesicles Orchestrate Cisplatin-Induced Ototoxicity: Potential Biomarker and Targets Discovery., PMID:40411396
Clinical characterization of CCT2 and its role in autophagy regulation during age-related macular degeneration., PMID:40374738
The BBS/CCT chaperonin complex ensures the localization of the adhesion G protein-coupled receptor ADGRV1 to the base of primary cilia., PMID:40103630
The conformational landscape of TRiC ring-opening and its underlying stepwise mechanism revealed by cryo-EM., PMID:40070846
Comparative proteomic and transcriptomic analysis of testicular tissue of yaks with or without cryptorchidism., PMID:40068345
Advances in Aggrephagy: Mechanisms, Disease Implications, and Therapeutic Strategies., PMID:39749851
Neuroprotective Effects of Chaperonin Containing TCP1 Subunit 2 (CCT2) on Motor Neurons Following Oxidative or Ischemic Stress., PMID:39614031
Unveiling biomarker detection in Alzheimer's disease: a computational approach to microarray analysis., PMID:39606011
The essential role of CCT2 in the regulation of aggrephagy., PMID:39478698
CCT2 Regulates ZEB1-Induced EMT Gene Transcription to Promote the Metastasis and Tumorigenesis of Papillary Thyroid Carcinoma., PMID:39327245
Two distinct regulatory pathways govern Cct2-Atg8 binding in the process of solid aggrephagy., PMID:39322741
Trim21-mediated CCT2 ubiquitination suppresses malignant progression and promotes CD4+T cell activation in breast cancer., PMID:39079960
Lassa virus Z protein hijacks the autophagy machinery for efficient transportation by interrupting CCT2-mediated cytoskeleton network formation., PMID:39007910
CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity., PMID:38869076
Compound heterozygous mutations in a mouse model of Leber congenital amaurosis reveal the role of CCT2 in photoreceptor maintenance., PMID:38830954
Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation., PMID:38827406
Effect of Calebin-A on Critical Genes Related to NAFLD: A Protein-Protein Interaction Network and Molecular Docking Study., PMID:38751599
Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights., PMID:38679420
Targeting the molecular chaperone CCT2 inhibits GBM progression by influencing KRAS stability., PMID:38582394
Discovery of a proliferation essential gene signature and actin-like 6A as potential biomarkers for predicting prognosis and neoadjuvant chemotherapy response in triple-positive breast cancer., PMID:38358781
PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity., PMID:38272236
A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis of hepatocellular carcinoma., PMID:38166853
CCT2 prevented β-catenin proteasomal degradation to sustain cancer stem cell traits and promote tumor progression in epithelial ovarian cancer., PMID:38165547
Circ-CCT2 Activates Wnt/β-catenin Signaling to Facilitate Hepatoblastoma Development by Stabilizing PTBP1 mRNA., PMID:37866478
Reduced ADP off-rate by the yeast CCT2 double mutation T394P/R510H which causes Leber congenital amaurosis in humans., PMID:37644231
A hierarchical assembly pathway directs the unique subunit arrangement of TRiC/CCT., PMID:37625406
Quantitative phosphoproteomics reveals molecular pathway network alterations in human early-stage primary hepatic carcinomas: potential for 3P medical approach., PMID:37605650
Tat-CCT2 Protects the Neurons from Ischemic Damage by Reducing Oxidative Stress and Activating Autophagic Removal of Damaged Protein in the Gerbil Hippocampus., PMID:37561257
Clinal variation in PHY (PAS domain) and CRY (CCT domain)-Signs of local adaptation to light quality in Norway spruce., PMID:37291974
Protein Aggregates and Aggrephagy in Myopathies., PMID:37176163
Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality., PMID:37118964
Multi-omics analysis revealed the role of CCT2 in the induction of autophagy in Alzheimer's disease., PMID:36704351
Exploring breast cancer exosomes for novel biomarkers of potential diagnostic and prognostic importance., PMID:36532861
Knockdown of METTL5 inhibits the Myc pathway to downregulate PD-L1 expression and inhibits immune escape of hepatocellular carcinoma cells., PMID:36369791
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy., PMID:36343628
Chaperonin containing TCP-1 (CCT/TRiC) is a novel therapeutic and diagnostic target for neuroblastoma., PMID:36185250
Leveraging orthology within maize and Arabidopsis QTL to identify genes affecting natural variation in gravitropism., PMID:36161933
Comprehensive prognostic and immunological analysis of CCT2 in pan-cancer., PMID:36119498
Construction of the coexpression network involved in the pathogenesis of thyroid eye disease via bioinformatics analysis., PMID:36076300
Chaperonin containing TCP1 as a marker for identification of circulating tumor cells in blood., PMID:35749519
CCT2, a newly identified aggrephagy receptor in mammals, specifically mediates the autophagic clearance of solid protein aggregates., PMID:35699934
Only solid waste, please!, PMID:35452612
TSPAN31 regulates the proliferation, migration, and apoptosis of gastric cancer cells through the METTL1/CCT2 pathway., PMID:35429902
Identification of host transcriptome-guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated bioinformatics approaches., PMID:35390032
A switch of chaperonin function regulates the clearance of solid protein aggregates., PMID:35380909
CCT2 is an aggrephagy receptor for clearance of solid protein aggregates., PMID:35366418
Multiomic analyses of two sorghum cultivars reveals the change of membrane lipids in their responses to water deficit., PMID:35217329
Identification of CDK1 as a candidate marker in cutaneous squamous cell carcinoma by integrated bioinformatics analysis., PMID:35116276
Molecular chaperone TRiC governs avian reovirus replication by protecting outer-capsid protein σC and inner core protein σA and non-structural protein σNS from ubiquitin- proteasome degradation., PMID:34826648
Proteomic characteristics of beryllium sulfate-induced differentially expressed proteins in rats., PMID:34733481
For research use only. Not for human or drug use.
