Catalog No.
YHF65501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro926-Glu1190
Predicted molecular weight
31.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P78357
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Contactin-associated protein 1, p190, NRXN4, CNTNAP1, CASPR, Caspr1, Neurexin-4, Neurexin IV, Caspr
A Novel Mutation in CNTNAP1 Gene Causes Disorganization of Axonal Domains, Hypomyelination and Severe Neurological Deficits., PMID:40265789
Anti-contactin-associated protein 1 antibody-positive nodopathy presenting with central nervous system symptoms., PMID:39084134
Mouse models of human CNTNAP1-associated congenital hypomyelinating neuropathy and genetic restoration of murine neurological deficits., PMID:37862170
Overlapping neurological phenotypes in two extended consanguineous families with novel variants in the CNTNAP1 and ADGRG1 genes., PMID:37178061
CNTNAP1-encephalopathy: Six novel patients surviving the neonatal period., PMID:35182943
[Analysis of CNTNAP1 gene variants in a Chinese pedigree affected with lethal congenital contracture syndrome type 7]., PMID:35076918
M2-polarization-related CNTNAP1 gene might be a novel immunotherapeutic target and biomarker for clear cell renal cell carcinoma., PMID:35023290
Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons., PMID:34370313
Antibodies to the Caspr1/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:33880507
Peripheral nerve hyperexcitability syndrome: A clinical, electrophysiological, and immunological study., PMID:33501683
Generation of High-Yield, Functional Oligodendrocytes from a c-myc Immortalized Neural Cell Line, Endowed with Staminal Properties., PMID:33498778
NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation., PMID:33238150
Mutations of CNTNAP1 led to defects in neuronal development., PMID:33148880
Antiparanodal antibodies and IgG subclasses in acute autoimmune neuropathy., PMID:32736337
NF155-overexpression promotes remyelination and functional restoration in a hypoxic-ischemic mixed neonatal rat forebrain cell culture system., PMID:31917235
Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype., PMID:31753915
Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS., PMID:31641127
Coordinated internodal and paranodal adhesion controls accurate myelination by oligodendrocytes., PMID:31451613
CNTNAP1 mutations in an adult with Charcot Marie Tooth disease., PMID:31397905
Behaviour and neuropathology in mice injected with human contactin-associated protein 2 antibodies., PMID:31079141
Anti-CNTN1 IgG3 induces acute conduction block and motor deficits in a passive transfer rat model., PMID:30953561
A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells., PMID:30792309
CNTNAP1-Related Congenital Hypomyelinating Neuropathy., PMID:30686628
Comparison of ion channel inhibitor combinations for limiting secondary degeneration following partial optic nerve transection., PMID:30367192
Increased adverse events associated with antiepileptic drugs in anti-leucine-rich glioma-inactivated protein 1 encephalitis., PMID:30159879
Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation., PMID:30010864
Caspr1 is a host receptor for meningitis-causing Escherichia coli., PMID:29895952
Absence of Axoglial Paranodal Junctions in a Child With CNTNAP1 Mutations, Hypomyelination, and Arthrogryposis., PMID:29882456
Autoantibodies Against the Node of Ranvier in Seropositive Chronic Inflammatory Demyelinating Polyneuropathy: Diagnostic, Pathogenic, and Therapeutic Relevance., PMID:29867996
Phenotype of CNTNAP1: a study of patients demonstrating a specific severe congenital hypomyelinating neuropathy with survival beyond infancy., PMID:29511323
Regulation and dysregulation of axon infrastructure by myelinating glia., PMID:29114067
Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures., PMID:28939043
Brain-relevant antibodies in first-episode psychosis: a matched case-control study., PMID:28920570
Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system., PMID:28827698
Axonal domain disorganization in Caspr1 and Caspr2 mutant myelinated axons affects neuromuscular junction integrity, leading to muscle atrophy., PMID:28370195
Identification of a novel CNTNAP1 mutation causing arthrogryposis multiplex congenita with cerebral and cerebellar atrophy., PMID:28254648
Human olfactory mesenchymal stromal cell transplants promote remyelination and earlier improvement in gait co-ordination after spinal cord injury., PMID:28144983
The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier., PMID:28134616
IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay., PMID:27852440
Activity-dependent formation and location of voltage-gated sodium channel clusters at a CNS nerve terminal during postnatal development., PMID:27832602
Contactin-Associated Protein 1 (CNTNAP1) Mutations Induce Characteristic Lesions of the Paranodal Region., PMID:27818385
Two novel variants in CNTNAP1 in two siblings presenting with congenital hypotonia and hypomyelinating neuropathy., PMID:27782105
Novel mutation in CNTNAP1 results in congenital hypomyelinating neuropathy., PMID:27668699
Mutations in GLDN, Encoding Gliomedin, a Critical Component of the Nodes of Ranvier, Are Responsible for Lethal Arthrogryposis., PMID:27616481
Reassembly of Excitable Domains after CNS Axon Regeneration., PMID:27581456
Chronic peripheral nerve compression disrupts paranodal axoglial junctions., PMID:27463510
Contactin-1 IgG4 antibodies cause paranode dismantling and conduction defects., PMID:27017186
Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression., PMID:26976207
Caspr Controls the Temporal Specification of Neural Progenitor Cells through Notch Signaling in the Developing Mouse Cerebral Cortex., PMID:26740489
[Morvan's syndrome (Morvan's fibrillary chorea)]., PMID:26480798
For research use only. Not for human or drug use.
