Catalog No.
YHF65303
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile6-Leu724
Predicted molecular weight
83.27 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>80% as determined by SDS-PAGE.
Accession
P78352
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PSD-95, PSD95, Disks large homolog 4, Synapse-associated protein 90, DLG4, Postsynaptic density protein 95, SAP-90, SAP90
Restoring endogenous Dlg4/PSD95 expression by an artificial transcription factor ameliorates cognitive and motor learning deficits in the R6/2 mouse model of Huntington's disease., PMID:40506760
Late-onset diagnosis of SHINE syndrome in an adolescent with developmental delay: Case report., PMID:40444229
Paeoniflorin Alleviates Lipopolysaccharide-Induced Neuroinflammation and Depression Through the Keap1/Nrf2/HO-1 Signaling Pathway., PMID:40427467
High-affinity detection of biotinylated endogenous neuroligin-1 at excitatory and inhibitory synapses using a tagged knock-in mouse., PMID:40424132
Activation of G protein-coupled estrogen receptor alleviates the abnormal changes of synaptic plasticity in the anterior insula of temporal lobe epilepsy rats through RhoA/Rock2 pathway., PMID:40373909
Investigating the protective effect of hydroxylated fullerenes on cognitive function in rats with temporal lobe epilepsy., PMID:40269130
Electroacupuncture Attenuates Nerve Injury in Cerebral Small Vessel Disease by Protecting the Neurovascular Units., PMID:40261465
Essential lipids enrich membrane-associated condensates to rescue synaptic morpho-functional deficits in a mouse model of autism., PMID:40232934
Donepezil Improves PSD95 Expression, Mitigates Neuroinflammation via PI3K/Akt/NF-κB and Mitochondrial Dysfunction in a Rodent Model of Subarachnoid Haemorrhage., PMID:40230034
An integrated approach of transcriptomics, network pharmacology and molecular docking uncovers the mechanisms of 5,6,7,4'-tetramethoxyflavone in treating cervical cancer., PMID:40157293
Premorbid characteristics of the SAPAP3 mouse model of obsessive-compulsive disorder: behavior, neuroplasticity, and psilocybin treatment., PMID:40156912
FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model., PMID:40152573
The effects of risperidone and voluntary exercise intervention on synaptic plasticity gene expressions in the hippocampus and prefrontal cortex of juvenile female rats., PMID:40096936
Maternal peptidoglycan overexposure during late pregnancy alters neurodevelopment and behavior in juvenile offspring., PMID:40058669
CRMP2 in the hippocampus alleviates chronic stress-induced depressive-like behaviours in mice by affecting synaptic function., PMID:40020760
Disruption of Extracellular Signal-Regulated Kinase Partially Mediates Neonatal Isoflurane Anesthesia-Induced Changes in Dendritic Spines and Cognitive Function in Juvenile Mice., PMID:39940749
[Saponins from Panax japonicus ameliorate high-fat diet-induced anxiety by modulating FGF21 resistance]., PMID:39929644
Effects of Qingyangshen glycosides on neuroplasticity in a mouse model of social defeat., PMID:39921215
Synaptic protein expression in bipolar disorder patient-derived neurons implicates PSD-95 as a marker of lithium response., PMID:39824303
Colistin treatment causes neuronal loss and cognitive impairment via ros accumulation and neuronal plasticity alterations., PMID:39823721
Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice., PMID:39774610
FN1 and VEGFA Are Potential Therapeutic Targets in Glioblastoma as Determined by Bioinformatics Analysis., PMID:39730176
[Electroacupuncture improves learning and memory function and promotes hippocampal synaptic regeneration in rats with cerebral ischemia-reperfusion injury]., PMID:39725620
3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain., PMID:39702971
DNA methylation profiling of CpG islands in trigeminal ganglion of rats with orofacial pain induced by experimental tooth movement., PMID:39633318
Early-life bisphenol A exposure causes detrimental age-related changes in anxiety, depression, learning, and memory in juvenile and adult male rats: Involvement of NMDAR/PSD-95-PTEN/AKT signaling pathway., PMID:39617347
Hesperidin produces antidepressant effects by activating AMPA receptor: enhancing synaptic proteins to promote hippocampal neuronal activities., PMID:39611623
Lactobacillus rhamnosus GG attenuates depression-like behaviour and cognitive deficits in chronic ethanol exposure mice by down-regulating systemic inflammatory factors., PMID:39585236
Sequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex., PMID:39570289
[Effect of electroacupuncture on synaptic ultrastructure and synaptic function related proteins PSD95 and MeCP2 in sleep deprivation rats]., PMID:39557433
Ameliorative effect and underlying mechanism of the Xiaxue Kaiqiao formula on age-related dementia in Samp8 mice., PMID:39536424
Analysis of Expression of the GRIPAP1, DLG4, KIF1B, NGFRAP1, and NRF1 Genes in Peripheral Blood of the Patients with Parkinson's Disease in the Early Clinical Stages., PMID:39523115
Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model., PMID:39511336
Ca2+-PP2B-PSD-95 axis: A novel regulatory mechanism of the phosphorylation state of Serine 295 of PSD-95., PMID:39509447
Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in App NL-G-F mice., PMID:39506961
Postnatal Neuronal Nogo-A Knockdown Decreased the Message of Glutamatergic Synaptic Proteins., PMID:39465566
Intranasal AdipoRon mitigates motor and cognitive deficits in hemiparkinsonian rats through neuroprotective mechanisms against oxidative stress and synaptic dysfunction., PMID:39393589
Long-read and short-read RNA-seq reveal the transcriptional regulation characteristics of PICK1 in Baoshan pig testis., PMID:39371543
SMP30 alleviates cerebral ischemia/reperfusion-induced neuronal injury by inhibiting HDAC4/PSD-95 to preserve mitochondrial function., PMID:39254519
Effect of Kruppel-like factor 4 on PTZ-induced acute seizure mice., PMID:39234952
Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications., PMID:39210294
MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis., PMID:39193909
Epigenetic alternations in the SYP and DLG4 genes due to low-level methylmercury exposure during neuronal differentiation in vitro., PMID:39187442
Effect of simultaneous application of adenosine A1 receptor agonist and A2A receptor antagonist on memory, inflammatory factors, and PSD-95 in lipopolysaccharide-induced memory impairment., PMID:39159786
Sex-dependent changes in AMPAR expression and Na, K-ATPase activity in the cerebellum and hippocampus of α-Klotho-Hypomorphic mice., PMID:39094831
Vitamin B6 Via p-JNK/Nrf-2/NF-κB Signaling Ameliorates Cadmium Chloride-Induced Oxidative Stress Mediated Memory Deficits in Mice Hippocampus., PMID:39092643
The DNA repair protein DNA-PKcs modulates synaptic plasticity via PSD-95 phosphorylation and stability., PMID:39085642
Physical Exercise Inhibits Cognitive Impairment and Memory Loss in Aged Mice, and Enhances Pre- and Post-Synaptic Proteins in the Hippocampus of Young and Aged Mice., PMID:39073519
Subchronic administration of scopolamine reverses UCMS-induced behavior in mice via eEF2 protein dephosphorylation., PMID:39042346
Interplay of miRNAs and molecular pathways in spaceflight-induced depression: Insights from a rat model using simulated complex space environment., PMID:39037540
For research use only. Not for human or drug use.
