Catalog No.
YHF54801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser2-Asn340
Predicted molecular weight
39.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P62879
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2, G protein subunit beta-2, Transducin beta chain 2, GNB2
Proteomic profiles screening identified novel exosomal protein biomarkers for diagnosis of lung cancer., PMID:40229672
Epidermal Growth Factor Receptor Emerges as a Viable Target for Reducing Tumorigenicity of MDCK Cells., PMID:39336799
LncRNA CCAT2 promotes the proliferation and metastasis of colorectal cancer through activation of the ERK and Wnt signaling pathways by regulating GNB2 expression., PMID:39225546
Assessment of NB-UVB Effects on Skin of Atopic Dermatitis Patients: A Network Analysis., PMID:39188927
O-demethyl galantamine alters protein expression in cerebellum of 5xFAD mice., PMID:39050707
Generation of a patient-specific hiPS cell line with heterozygous GNB2 mutation (UKMi003-A) causative for human sinus node dysfunction and a corresponding CRISPR/Cas9-corrected isogenic control (UKMi004-A)., PMID:38776645
Investigating neuropathological changes and underlying neurobiological mechanisms in the early stages of primary blast-induced traumatic brain injury: Insights from a rat model., PMID:38373483
miR-142-3p improves paclitaxel sensitivity in resistant breast cancer by inhibiting autophagy through the GNB2-AKT-mTOR Pathway., PMID:36539001
Macrophages-Related Genes Biomarkers in the Deterioration of Atherosclerosis., PMID:35845072
A detailed multi-omics analysis of GNB2 gene in human cancers., PMID:35730811
Predicting Novel Drug Candidates for Pancreatic Neuroendocrine Tumors via Gene Signature Comparison and Connectivity Mapping., PMID:35508682
A Computational Framework to Identify Biomarkers for Glioma Recurrence and Potential Drugs Targeting Them., PMID:35116059
A Novel Classification of Glioma Subgroup, Which Is Highly Correlated With the Clinical Characteristics and Tumor Tissue Characteristics, Based on the Expression Levels of Gβ and Gγ Genes., PMID:34222011
Recurrent de novo missense variants in GNB2 can cause syndromic intellectual disability., PMID:34183358
A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome., PMID:34124757
Second patient with GNB2-related neurodevelopmental disease: Further evidence for a gene-disease association., PMID:33971351
cAMP/PKA/CREB signaling pathway-mediated effects of melatonin receptor genes on clock gene expression in Bactrian camel ovarian granulosa cells., PMID:33636446
FUS-induced circular RNA ZNF609 promotes tumorigenesis and progression via sponging miR-142-3p in lung cancer., PMID:33459380
Lycium barbarum Polysaccharide Antagonizes LPS-Induced Inflammation by Altering the Glycolysis and Differentiation of Macrophages by Triggering the Degradation of PKM2., PMID:33390389
Identification of the Key Genes Involved in the Effect of Folic Acid on Endothelial Progenitor Cell Transcriptome of Patients with Type 1 Diabetes., PMID:33029194
An integrative bioinformatics analysis of caprine GNAI3 gene., PMID:32366735
High-throughput, Label-Free Quantitative Proteomic Studies of the Anticancer Effects of Electrical Pulses with Turmeric Silver Nanoparticles: an in vitro Model Study., PMID:32350346
Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis., PMID:32332099
Identification of key genes involved in the pathogenesis of cutaneous melanoma using bioinformatics analysis., PMID:31937175
Exome reports A de novo GNB2 variant associated with global developmental delay, intellectual disability, and dysmorphic features., PMID:31698099
Identification of potential diagnostic and prognostic biomarkers for prostate cancer., PMID:31579071
Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K+ Channel) Channel Function., PMID:30645171
Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina., PMID:30425286
DDX3 Participates in Translational Control of Inflammation Induced by Infections and Injuries., PMID:30373933
Molecular pathogenesis of disease progression in MLL-rearranged AML., PMID:30209403
Integration of miRNA and mRNA Co-Expression Reveals Potential Regulatory Roles of miRNAs in Developmental and Immunological Processes in Calf Ileum during Early Growth., PMID:30208606
Pacing Discovery: G-Protein β Subunit Mutations in Sinus Node Dysfunction., PMID:28495981
Suppression subtractive hybridization identified differentially expressed genes in colorectal cancer: microRNA-451a as a novel colorectal cancer-related gene., PMID:28468585
A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction., PMID:28219978
Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice., PMID:27534535
GNB2 is a mediator of lidocaine-induced apoptosis in rat pheochromocytoma PC12 cells., PMID:27018092
Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo., PMID:26468229
Mutations in G protein β subunits promote transformation and kinase inhibitor resistance., PMID:25485910
Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma., PMID:24603425
Protein kinase C epsilon and genetic networks in osteosarcoma metastasis., PMID:24216982
Identification of cellular proteins interacting with influenza A virus PB1-F2 protein., PMID:23043599
Ovine corpus luteum proteins, with functions including oxidative stress and lipid metabolism, show complex alterations during implantation., PMID:21478226
Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled., PMID:19561403
Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes., PMID:11913780
Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes., PMID:9799793
Direct selection: a method for the isolation of cDNAs encoded by large genomic regions., PMID:1946378
The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8., PMID:2328987
Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human., PMID:2902634
For research use only. Not for human or drug use.
