Catalog No.
YHF33401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala3-Leu165
Predicted molecular weight
21.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P59998
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ARPC4, p20-ARC, Actin-related protein 2/3 complex subunit 4, Arp2/3 complex 20 kDa subunit, ARC20
Akt-phosphorylated UFL1 UFMylates ArpC4 to promote metastasis., PMID:40419786
Targeted Regulation of HSP70 by the ARP2/3 Complex in Mammary Epithelial Cells and Its Impact on Host Cell Apoptosis., PMID:40305275
[Aurora-A overexpression promotes cervical cancer cell invasion and metastasis by activating the NF-κBp65/ARPC4 signaling axis]., PMID:40294934
Cytochalasin B Mitigates the Inflammatory Response in Lipopolysaccharide-Induced Mastitis by Suppressing Both the ARPC3/ARPC4-Dependent Cytoskeletal Changes and the Association Between HSP70 and the NLRP3 Inflammasome., PMID:40243637
Activation of ARP2/3 and HSP70 Expression by Lipoteichoic Acid: Potential Bidirectional Regulation of Apoptosis in a Mastitis Inflammation Model., PMID:39199289
Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening., PMID:38561797
A novel variant of ARPC4-related neurodevelopmental disorder., PMID:36513617
Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins., PMID:36429089
Dynamic miRNA profile of host T cells during early hepatic stages of Schistosoma japonicum infection., PMID:36119054
Effects of lipoteichoic and arachidonic acids on the immune-regulatory mechanism of bovine mammary epithelial cells using multi-omics analysis., PMID:36090174
p53 Related Protein Kinase is Required for Arp2/3-Dependent Actin Dynamics of Hemocytes in Drosophila melanogaster., PMID:35721516
Identifying Novel Osteoarthritis-Associated Genes in Human Cartilage Using a Systematic Meta-Analysis and a Multi-Source Integrated Network., PMID:35457215
A recurrent, de novo pathogenic variant in ARPC4 disrupts actin filament formation and causes microcephaly and speech delay., PMID:35047857
Expression of actin- and oxidative phosphorylation-related transcripts across the cortical visuospatial working memory network in unaffected comparison and schizophrenia subjects., PMID:35034100
Identification of Arp2/3 Complex Subunits as Prognostic Biomarkers for Hepatocellular Carcinoma., PMID:34307456
mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote KrasG12D-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis., PMID:33388318
mir-124-5p Regulates Phagocytosis of Human Macrophages by Targeting the Actin Cytoskeleton via the ARP2/3 Complex., PMID:31636629
ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis., PMID:31190401
Serum Proteomic Signatures of Male Breast Cancer., PMID:30850364
Short interfering RNA-mediated silencing of actin-related protein 2/3 complex subunit 4 inhibits the migration of SW620 human colorectal cancer cells., PMID:29435011
Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2., PMID:29113991
Deciphering the protein-protein interaction network regulating hepatocellular carcinoma metastasis., PMID:28627476
The role of viral protein Ac34 in nuclear relocation of subunits of the actin-related protein 2/3 complex., PMID:27900558
Protein Interaction Network of Human Protein Kinase D2 Revealed by Chemical Cross-Linking/Mass Spectrometry., PMID:27559607
Comparative Proteomic Profiling of Extracellular Proteins between Normal and Gastric Cancer Cells., PMID:26648486
Novel identification of Dermacentor variabilis Arp2/3 complex and its role in rickettsial infection of the arthropod vector., PMID:24733187
ARP2/3 complex-mediated actin dynamics is required for hydrogen peroxide-induced stomatal closure in Arabidopsis., PMID:24372484
Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells., PMID:24085853
Expression of the ARPC4 subunit of human Arp2/3 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages., PMID:23894563
Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration., PMID:23267127
FK1706, a novel non-immunosuppressive immunophilin ligand, modifies gene expression in the dorsal root ganglia during painful diabetic neuropathy., PMID:22642793
Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation., PMID:22125478
Molecular dynamics simulations of Arp2/3 complex activation., PMID:20959098
An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability., PMID:20404198
The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleation., PMID:20071330
The association of the Arabidopsis actin-related protein2/3 complex with cell membranes is linked to its assembly status but not its activation., PMID:19801398
Nucleotide- and activator-dependent structural and dynamic changes of arp2/3 complex monitored by hydrogen/deuterium exchange and mass spectrometry., PMID:19298826
Molecular dynamics simulation and coarse-grained analysis of the Arp2/3 complex., PMID:18805923
Functional surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis., PMID:18381280
BRICK1 is required for apical cell growth in filaments of the moss Physcomitrella patens but not for gametophore morphology., PMID:18263777
The role of ARPC4 in tip growth and alignment of the polar axis in filaments of Physcomitrella patens., PMID:16450411
DISTORTED2 encodes an ARPC2 subunit of the putative Arabidopsis ARP2/3 complex., PMID:15086808
Identification of functionally important residues of Arp2/3 complex by analysis of homology models from diverse species., PMID:14757065
Crystal structure of Arp2/3 complex., PMID:11721045
For research use only. Not for human or drug use.
