Catalog No.
YHF23901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro278-His484
Predicted molecular weight
24.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P57764
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GSDMD-CT, hGSDMD-NTD, Gasdermin domain-containing protein 1, Gasdermin-D, DFNA5L, GSDMD-NT, hGSDMD-CTD, GSDMDC1, GSDMD
Single cell analysis and bioinformatics reveal pyroptosis mechanisms in hepatocellular carcinoma., PMID:40516009
Dahuang Huanglian Decoction alleviates dysbiosis by inhibiting GBP5/NLRP3 signaling pathway-mediated pyroptosis of colonic epithelial cells., PMID:40513920
Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis., PMID:40512290
Activation of pyroptosis impairs basal cell differentiation in the nasal epithelium in chronic rhinosinusitis with nasal polyps., PMID:40511559
MicroRNAs as regulators of NLRP3 inflammasome activation in herpes simplex virus type 2 infection., PMID:40510795
GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses., PMID:40503916
Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome., PMID:40501605
Copper exposure elicits pyroptosis and inflammation in bursa of Fabricius and omega-3 reverses this phenomenon by inhibiting NF-κB-NLRP3-GSDMD axis: In vivo, in vitro, and in silico investigations., PMID:40500068
Dipeptidyl Peptidase 9 in Human Leukocytes: Novel Inhibitors Induce Caspase-1- and Gasdermin-Dependent Cell Death., PMID:40498275
Unlocking the therapeutic potential of protocatechualdehyde: pharmacological applications and mechanism insights., PMID:40493248
HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway., PMID:40492985
GSDMD is a novel predictive biomarker for immunotherapy response: in the pan-cancer and single cell landscapes., PMID:40491921
DCAAA mitigates neuroinflammation and microglial pyroptosis in spinal cord injury by inhibiting PI3K/AKT/NF-κB and NLRP3/caspase-1/GSDMD signaling., PMID:40490166
Melastoma dodecandrum polysaccharide alleviates allergic rhinitis in mice through modulating NLRP3 and IL-17 axis., PMID:40489908
Macrophage pyroptosis mediates hyperoxia-induced inflammatory lung injury in neonates., PMID:40486518
Inhibiting NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis: A New Role of GADD45B's Role in Hypertriglyceridemia-Induced Acute Pancreatitis., PMID:40485526
Caspase-8-driven NLRP3 inflammasome activation exacerbates bronchopulmonary dysplasia by increasing the apoptosis and pyroptosis crosstalk of alveolar epithelial cells., PMID:40483833
Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection., PMID:40481027
Kaempferol inhibits oxidative stress and reduces macrophage pyroptosis by activating the NRF2 signaling pathway., PMID:40478791
Vanillin alleviates oxidative stress-mediated neuronal pyroptosis induced in rats by isoproterenol via SIRT1/NOX4/ROS/TXNIP/NLRP3 signaling pathway., PMID:40478189
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis., PMID:40473047
NAD+ Metabolism Maintains the Homeostasis of Decidual Macrophages in Early Pregnancy., PMID:40471104
Integrated proteomics analysis and network pharmacology to elucidate the mechanism of Zhilong Huoxue Tongyu Capsule alleviate hypertensive retinopathy in Ang II infusion mice model., PMID:40469974
RBM15 promotes m6A methylation and stability of KLF6 mRNA to accelerate pyroptosis of retinal ganglion cells in early-stage diabetic retinopathy., PMID:40464812
Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis., PMID:40462493
Emodin influences pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats., PMID:40461604
[Mechanism of vanillic acid against cardiac fibrosis induced by isoproterenol in mice based on Drp1/HK1/NLRP3 and mitochondrial apoptosis signaling pathways]., PMID:40461229
[Polysaccharide extract PCP1 from Polygonatum cyrtonema ameliorates cerebral ischemia-reperfusion injury in rats by inhibiting TLR4/NLRP3 pathway]., PMID:40461201
[Effects of Yishen Yangsui formula() on pyroptosis in the spinal cord tissue in rats with degenerative cervical myelopathy]., PMID:40461117
Modified Citrus Pectin Alleviates Diabetic Kidney Disease by Suppressing Pyroptosis in Renal Tubular Epithelial Cells via the Cx43-ERK1/2 Signaling Pathway., PMID:40460282
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy., PMID:40451585
METTL3-mediated m6A modification of FUNDC1/IP3R2 pathway facilitates cardiac hypertrophy in obesity hypertension., PMID:40451326
A novel inflammatory biomarker in assessing disease activity in ulcerative colitis: gasdermin D., PMID:40447992
XBP1 Knockdown Alleviates Pyroptosis and Promotes Th17/Treg Imbalance in Periodontitis by Inhibiting the IL-17 Signaling Pathway., PMID:40447963
ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D., PMID:40440066
VSV-CHIKV activates antitumor immunity by inducing pyroptosis in a melanoma model., PMID:40439822
Gasdermin D-Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis., PMID:40439590
ADSC-derived exosomes mitigate radiation-induced skin injury by reducing oxidative stress, inflammation and cell death., PMID:40438040
Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males., PMID:40435214
Impaired Mitophagy Contributes to Pyroptosis in Sarcopenic Obesity Zebrafish Skeletal Muscle., PMID:40431451
Transcriptomic and Immunopathological Profiles of Inflammasomes in Different Clinical Forms of American Cutaneous Leishmaniasis., PMID:40431153
Lingguizhugan decoction ameliorates renal injury secondary to heart failure by improving pyroptosis through TLR4/NF-KB/IRE1α pathway., PMID:40424980
Effects of Adipose-Derived Mesenchymal Stem Cell-Secretome on Pyroptosis of Laparoscopic Hepatic Ischemia Reperfusion Injury in a Porcine Model., PMID:40422225
Gasdermin D: A New Inflammatory Biomarker in Assessing Clinical Disease Activity in Crohn's Disease., PMID:40418140
[Asiaticoside alleviates myocardial ischemia-reperfusion injury in rats by inhibiting NLRP3 inflammasome-mediated pyroptosis]., PMID:40415429
CEBPD is a pivotal factor for the activation of NLRP3 inflammasome in traumatic brain injury., PMID:40414072
miR-29a nanoparticles improve chronic insomnia by regulating microglia activation and hippocampal neuronal cell pyroptosis through PER2/NF-κB axis., PMID:40412133
Mitigating PCOS progression: The protective effect of C-phycocyanin on ovarian granulosa cell pyroptosis via the NRF2/NLRP3/GSDMD pathway., PMID:40412127
Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway., PMID:40406492
Paris saponin VII attenuates psoriasiform inflammation by regulating STAT3/NFκB signaling pathway and Caspase-1-induced pyroptosis., PMID:40405066
For research use only. Not for human or drug use.
