Catalog No.
YHF20201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu240
Predicted molecular weight
28.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P56945
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, CASS1, Cas scaffolding protein family member 1, CRKAS, BCAR1, CAS, p130cas
The p130Cas-Crk/CrkL Axis: A Therapeutic Target for Invasive Cancers Unveiled by Collaboration Among p130Cas, Crk, and CrkL., PMID:40362257
Dynamic Remodeling of Mechano-Sensing Complexes in Suspended Fibroblast Cell-Sheets Under External Mechanical Stimulus., PMID:40270085
Rac1 Suppression by the Focal Adhesion Protein GIT ArfGAP2 and Podocyte Protection., PMID:40019803
Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer., PMID:39890846
FAK and p130Cas Modulate Stiffness-Mediated Early Transcription and Cellular Metabolism., PMID:39651636
BCAR1 facilitates the survival of lung adenocarcinoma cells by augmenting the unfolded protein response, autophagy, and the formation of vasculogenic mimicry., PMID:39488300
The role of p130Cas/BCAR1 adaptor protein in the pathogenesis of cardiovascular diseases: A literature review., PMID:39036012
Use of phosphotyrosine-containing peptides to target SH2 domains: Antagonist peptides of the Crk/CrkL-p130Cas axis., PMID:38886037
Cerebral furin deficiency causes hydrocephalus in mice., PMID:38292192
Lead optimization of Allium sativum L. compounds for PTP1B inhibition in diabetes treatment: in silico molecular docking and dynamics simulation., PMID:38109128
Exploring lncRNAs associated with human pancreatic islet cell death induced by transfer of adoptive lymphocytes in a humanized mouse model., PMID:38027148
FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling., PMID:37928269
Cas phosphorylation regulates focal adhesion assembly., PMID:37489578
Creatine kinase brain-type regulates BCAR1 phosphorylation to facilitate DNA damage repair., PMID:37182100
p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands., PMID:36991029
Propagated Circulating Tumor Cells Uncover the Potential Role of NFκB, EMT, and TGFβ Signaling Pathways and COP1 in Metastasis., PMID:36980717
The E2F4/p130 Repressor Complex Cooperates with Oncogenic ΔNp73α To Inhibit Gene Expression in Human Papillomavirus 38 E6/E7-Transformed Keratinocytes and in Cancer Cells., PMID:36883841
Role of cytoskeleton-related proteins in the acrosome reaction of Eriocheir sinensis spermatozoa., PMID:36782118
Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals., PMID:36737517
The interaction of CFLAR with p130Cas promotes cell migration., PMID:36400248
BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1., PMID:36375119
Genetic Overlap Analysis Identifies a Shared Etiology between Migraine and Headache with Type 2 Diabetes., PMID:36292730
Characterization of the sex determining region of channel catfish (Ictalurus punctatus) and development of a sex-genotyping test., PMID:36191824
Combining Recombinase-Mediated Cassette Exchange Strategy with Quantitative Proteomic and Phosphoproteomic Analyses to Inspect Intracellular Functions of the Tumor Suppressor Galectin-4 in Colorectal Cancer Cells., PMID:35742860
Novel germline mutation in lung cancer pedigrees establishes BCAR1 as a human cancer susceptibility gene: a case report., PMID:35280415
Endothelial p130cas confers resistance to anti-angiogenesis therapy., PMID:35081345
Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes., PMID:35031902
Protumor Effects of Histone H3-H4 Chaperone Antisilencing Feature 1B Gene on Lung Adenocarcinoma: In Silico and In Vitro Analyses., PMID:34956399
Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis., PMID:34922945
p130Cas Is Correlated with EREG Expression and a Prognostic Factor Depending on Colorectal Cancer Stage and Localization Reducing FOLFIRI Efficacy., PMID:34830244
p130Cas/BCAR1 and p140Cap/SRCIN1 Adaptors: The Yin Yang in Breast Cancer?, PMID:34708040
Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis., PMID:34592494
Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing., PMID:34526996
The unique function of p130Cas in regulating the bone metabolism., PMID:34391790
BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma., PMID:34326687
Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract., PMID:34270692
Shape of promoter antisense RNAs regulates ligand-induced transcription activation., PMID:34194047
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition., PMID:34192548
A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics., PMID:34169835
Proteasomal degradation of p130 facilitate cell cycle deregulation and impairment of cellular differentiation in high-risk Human Papillomavirus 16 and 18 E7 transfected cells., PMID:34169395
The role of E26 transformation-specific variant transcription factor 5 in colorectal cancer cell proliferation and cell cycle progression., PMID:33931578
Phosphorylation regulates cullin-based ubiquitination in tumorigenesis., PMID:33643814
The roles of microbial products in the development of colorectal cancer: a review., PMID:33618627
Suppression of macrophage migration by down-regulating Src/FAK/P130Cas activation contributed to the anti-inflammatory activity of sinomenine., PMID:33617975
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer., PMID:33517887
Key Role of CD151-integrin Complex in Lung Cancer Metastasis and Mechanisms Involved., PMID:33428143
Src kinase: Key effector in mechanosignalling., PMID:33359015
High Expression of BCAR1 by Circulating Tumor Cells and Tumor Tissues Is Predictive of a Poor Prognosis of Early-Stage Lung Adenocarcinoma Potentially Due to Regulation of Epithelial-Mesenchymal Transition., PMID:33334252
Identification of adhesion-associated DNA methylation patterns in the peripheral nervous system., PMID:33273976
Heart failure impairs the mechanotransduction properties of human cardiac pericytes., PMID:33159916
For research use only. Not for human or drug use.
