Catalog No.
YHF17501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu252
Predicted molecular weight
30.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P56545
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
C-terminal-binding protein 2, CTBP2, CtBP2
A Single Dose of AC102 Reverts Tinnitus by Restoring Ribbon Synapses in Noise-Exposed Mongolian Gerbils., PMID:40507934
C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation., PMID:40490364
Recombinant human Neuritin protects cochlear ribbon synapses and hearing function via ERK1/2 activation post noise-induced injury., PMID:40476059
A novel DNA binding protein encoded by circZNF131 inhibits the growth of gastric cancer by suppressing CTBP2 transcription., PMID:40381776
Transcriptome-Wide Analysis and Experimental Validation from FFPE Tissue Identifies Stage-Specific Gene Expression Profiles Differentiating Adenoma, Carcinoma In-Situ and Adenocarcinoma in Colorectal Cancer Progression., PMID:40362431
VDAC1 Inhibition Protects Against Noise-Induced Hearing Loss via the PINK1/Parkin Pathway., PMID:40285415
The transcriptional repressor Ctbp2 as a metabolite sensor regulating cardiomyocytes proliferation and heart regeneration., PMID:40140769
CtBP2 Regulates Wnt Signal Through EGR1 to Influence the Proliferation and Apoptosis of DLBCL Cells., PMID:40099624
C-terminal binding protein-2 triggers CYR61-induced metastatic dissemination of osteosarcoma in a non-hypoxic microenvironment., PMID:40038783
Investigating the expression profiles of cysteine string proteins (CSPs) in cochlear tissue., PMID:39776541
Proteomic analysis of the nonstructural protein 2-host protein interactome reveals a novel regulatory role of SH3 domain-containing kinase-binding protein 1 in porcine reproductive and respiratory syndrome virus replication and apoptosis., PMID:39755310
Phosphorylation-mediated disassembly of C-terminal binding protein 2 tetramer impedes epigenetic silencing of pluripotency in mouse embryonic stem cells., PMID:39588763
PNSC5325 prevents acute respiratory distress syndrome by alleviating inflammation and inhibiting extracellular matrix degradation of alveolar macrophages., PMID:39520964
Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation., PMID:39511451
Clinical significance of peripheral blood DDR1 and CtBP gene methylation detection in patients with acute pancreatitis., PMID:39485950
The quantification and mRNA expression levels of cochlear synapses in C57BL/6j mice following repeated exposure to noise., PMID:39432246
The prion protein is required for normal responses to light stimuli by photoreceptors and bipolar cells., PMID:39381753
Differential chromatin accessibility and Gene Expression Associated with Backfat Deposition in pigs., PMID:39349998
BBOX1-AS1 promotes gastric cardia adenocarcinoma progression via interaction with CtBP2 to facilitate the epithelial-mesenchymal transition process., PMID:39318101
Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis., PMID:39265800
Ling-gui-zhu-gan promotes adipocytes browning via targeting the miR-27b/PRDM16 pathway in 3T3-L1 cells., PMID:39206264
Analytical Post-Embedding Immunogold-Electron Microscopy with Direct Gold-Labelled Monoclonal Primary Antibodies against RIBEYE A- and B-Domain Suggests a Refined Model of Synaptic Ribbon Assembly., PMID:39000549
C-Terminal Binding Protein: Regulator between Viral Infection and Tumorigenesis., PMID:38932279
The miR-182-5p/GPX4 Pathway Contributes to Sevoflurane-Induced Ototoxicity via Ferroptosis., PMID:38928480
PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome., PMID:38902802
Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2., PMID:38748792
CTBP2 contributes to cisplatin resistance in lung adenocarcinoma by inhibiting generation of reactive oxygen species., PMID:38737699
Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells., PMID:38711119
Patient-derived castration-resistant prostate cancer model revealed CTBP2 upregulation mediated by OCT1 and androgen receptor., PMID:38698344
Tissue-specific gene expression of genome-wide significant loci associated with major depressive disorder subtypes., PMID:38663672
C-terminal binding protein 2 is a novel tumor suppressor targeting the MYC-IRF4 axis in multiple myeloma., PMID:38457926
Abnormal α-Synuclein Aggregates Cause Synaptic- and Microcircuit-Specific Deficits in the Retinal Rod Pathway., PMID:38395146
Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway., PMID:38183983
Role of Ribeye PXDLS/T-binding cleft in normal synaptic ribbon function., PMID:38168344
Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion., PMID:37979214
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma., PMID:37949862
C-Terminal Binding Protein 2 Emerges as a Critical Player Linking Metabolic Imbalance to the Pathogenesis of Obesity., PMID:37793810
Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer., PMID:37707363
Accumulation of advanced glycation end products promotes atrophic nonunion incidence in mice through a CtBP1/2-dependent mechanism., PMID:37696386
Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing., PMID:37694353
Loss of synaptic ribbons is an early cause in ROS-induced acquired sensorineural hearing loss., PMID:37666363
The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head and neck squamous cell carcinoma., PMID:37643007
Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function., PMID:37557182
Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity., PMID:37286039
Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis., PMID:37163116
CtBP Neuroprotective Role in Toxin-Based Parkinson's Disease Models: From Expression Pattern to Dopaminergic Survival., PMID:37060501
Sex differences in hearing impairment due to diet-induced obesity in CBA/Ca mice., PMID:36810096
Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2., PMID:36790589
Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma., PMID:36768307
Epigenome alterations in food allergy: A systematic review of candidate gene and epigenome-wide association studies., PMID:36756739
For research use only. Not for human or drug use.
