Catalog No.
YHF14001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr40-Leu489
Predicted molecular weight
51.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P55809
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
3-oxoacid CoA-transferase 1, OXCT1, Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial, Somatic-type succinyl-CoA:3-oxoacid CoA-transferase, OXCT, SCOT, SCOT-s
Heat Shock Strengthens the Protective Potential of MSCs in Liver Injury by Promoting EV Release Through Upregulated Autophagosome Formation., PMID:40326673
Identification and Validation of Ferritinophagy-Related Biomarkers in Periodontitis., PMID:40233623
β-hydroxybutyrate serves as a regulator in ketone body metabolism through lysine β-hydroxybutyrylation., PMID:40185231
3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca2+-NFAT Signaling Pathways., PMID:40099866
Spatial Metabolomics and Transcriptomics Reveal Metabolic Reprogramming and Cellular Interactions in Nasopharyngeal Carcinoma with High PD-1 Expression and Therapeutic Response., PMID:40083932
Partial Regulation of Ketone Metabolism by Hypoxia in H9C2 Cardiomyocytes., PMID:39976748
Integrative analysis of genes provides insights into the molecular and immune characteristics of mitochondria-related genes in atherosclerosis., PMID:39914597
OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth., PMID:39862868
The effect of the production system on the proteomics profiles of the Longissimus thoracis muscle in Arouquesa cattle., PMID:39084571
Protective Effect of Long Noncoding RNA OXCT1-AS1 on Doxorubicin-Induced Apoptosis of Human Myocardial Cells by the Competitive Endogenous RNA Pattern., PMID:38958296
Protocol for identifying OXCT1-mediated LACTB succinylation sites in vitro., PMID:38787728
Identification of important modules and biomarkers in diabetic cardiomyopathy based on WGCNA and LASSO analysis., PMID:38469146
ACAT2 may be a novel predictive biomarker and therapeutic target in lung adenocarcinoma., PMID:38213102
OXCT1 regulates hippocampal neurogenesis and alleviates cognitive impairment via the Akt/GSK-3β/β-catenin pathway after subarachnoid hemorrhage., PMID:38199308
OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB., PMID:38176415
Empagliflozin improves mitochondrial dysfunction in diabetic cardiomyopathy by modulating ketone body metabolism and oxidative stress., PMID:38160540
Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models., PMID:38042218
Tandem mass tag-based quantitative proteomic analysis identification of succinylation related proteins in pathogenesis of thoracic aortic aneurysm and aortic dissection., PMID:37193023
A Novel Mutation in the OXCT1 Gene Causing Succinyl-CoA:3-Ketoacid CoA Transferase (SCOT) Deficiency Starting with Neurologic Manifestations., PMID:37091464
Neuroprotective mechanisms of OXCT1 via the SIRT3-SOD2 pathway after traumatic brain injury., PMID:36921750
The Association of Ketolytic Enzymes Gene Expression Levels with Mitochondrial Activity and Content in Oral Squamous Cell Carcinoma., PMID:36444610
Protein succinylation associated with the progress of hepatocellular carcinoma., PMID:36308411
Proteomics study of mitochondrial proteins in tilapia red meat and their effect on color change during storage., PMID:36084591
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer., PMID:36031388
Frataxin controls ketone body metabolism through regulation of OXCT1., PMID:36016708
LncRNA OXCT1-AS1 promotes the proliferation of non-small cell lung cancer cells by targeting the miR-195/CCNE1 axis., PMID:35706791
CircRNA OXCT1 promotes the malignant progression and glutamine metabolism of non-small cell lung cancer by absorbing miR-516b-5p and upregulating SLC1A5., PMID:35482822
Identification of Novel Key Molecular Signatures in the Pathogenesis of Experimental Diabetic Kidney Disease., PMID:35432190
Investigation of gene expression and genetic simultaneous control associated with erectile dysfunction and diabetes., PMID:34933709
Clinical variability and outcome of succinyl-CoA:3-ketoacid CoA transferase deficiency caused by a single OXCT1 mutation: Report of 17 cases., PMID:34765403
Multiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate., PMID:34683848
Proteomic Response of Rat Pituitary Under Chronic Mild Stress Reveals Insights Into Vulnerability and Resistance to Anxiety or Depression., PMID:34603401
Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuel., PMID:34584218
A novel lncRNA-mRNA-miRNA signature predicts recurrence and disease-free survival in cervical cancer., PMID:34550275
Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone Body Metabolism to the Ketogenic Diet., PMID:34456688
lncRNA OXCT1-AS1 Promotes Metastasis in Non-Small-Cell Lung Cancer by Stabilizing LEF1, In Vitro and In Vivo., PMID:34337014
Succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) deficiency: A rare and potentially fatal metabolic disease., PMID:33596448
Identification of Potential Therapeutic Targets of Alzheimer's Disease By Weighted Gene Co-Expression Network Analysis., PMID:33413749
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization., PMID:32750298
Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis., PMID:32523351
Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure., PMID:32493060
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction., PMID:32341350
Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation., PMID:32275862
The contribution of ketone bodies to glycolytic inhibition for the treatment of adult and pediatric glioblastoma., PMID:32096068
Proanthocyanidins Limit Adipose Accrual Induced by a Cafeteria Diet, Several Weeks after the End of the Treatment., PMID:31398921
miRNAs, target genes expression and morphological analysis on the heart in gestational protein-restricted offspring., PMID:31034522
Transcriptome analysis to identify long non coding RNA (lncRNA) and characterize their functional role in back fat tissue of pig., PMID:30954676
Role of OXCT1 in ovine adipose and preadipocyte differentiation., PMID:30928098
Nicorandil alleviated cardiac hypoxia/reoxygenation-induced cytotoxicity via upregulating ketone body metabolism and ACAT1 activity., PMID:30627008
Microarray expression profiles analysis revealed lncRNA OXCT1-AS1 promoted bladder cancer cell aggressiveness via miR-455-5p/JAK1 signaling., PMID:30609030
For research use only. Not for human or drug use.
