Catalog No.
YHF11601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu166
Predicted molecular weight
20.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P55273
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p19-INK4d, Cyclin-dependent kinase 4 inhibitor D, CDKN2D
Cas9 Mouse Model of Skull Base Meningioma Driven by Combinational Gene Inactivation in Meningeal Cells., PMID:39996452
Occurrence of cellular senescence in chronic human shoulder tendinopathies and its attenuation ex vivo by inhibition of Enhancer of Zeste 2., PMID:39996291
Aged mice overexpressing cellular repressor of E1A-stimulated genes 1 in adipose tissues exhibited increased liposarcoma incidence and shortened lifespan., PMID:39978253
Elimination of physiological senescent cutaneous cells in a novel p16-dependent senolytic mouse model impacts lipid metabolism in skin aging., PMID:39284569
Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes accelerates the development of myelofibrosis., PMID:38378843
Podocyte injury at young age causes premature senescence and worsens glomerular aging., PMID:37855038
Polysaccharide from Paris polyphylla improves learning and memory ability in D-galactose-induced aging model mice based on antioxidation, p19/p53/p21, and Wnt/β-catenin signaling pathways., PMID:37579895
The mirror like expression of genes involved in the FOXO signaling pathway could be effective in the pathogenesis of human lymphotropic virus type 1 (HTLV-1) through disruption of the downstream pathways., PMID:37461070
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer., PMID:37261974
BMI1 is required for melanocyte stem cell maintenance and hair pigmentation., PMID:37132544
CDK regulators-Cell cycle progression or apoptosis-Scenarios in normal cells and cancerous cells., PMID:37061330
Immortalized murine tenocyte cells: a novel and innovative tool for tendon research., PMID:36709227
Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families., PMID:36696417
Central gene transcriptional regulatory networks shaping monocyte development in bone marrow., PMID:36304450
Identification of Cdk8 and Cdkn2d as New Prame-Target Genes in 2C-like Embryonic Stem Cells., PMID:36292630
A protein synthesis brake for hematopoietic stem cell maintenance., PMID:36207141
Bmi1 suppresses protein synthesis and promotes proteostasis in hematopoietic stem cells., PMID:36167470
Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma., PMID:35538224
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology., PMID:35531351
The Cdkn2a gene product p19 alternative reading frame (p19ARF) is a critical regulator of IFNβ-mediated Lyme arthritis., PMID:35324997
Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging., PMID:35159350
Loss of p19Arf promotes fibroblast survival during leucine deprivation., PMID:34994382
A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a therapeutic target., PMID:34921235
Decreased proliferation of aged rat beta cells corresponds with enhanced expression of the cell cycle inhibitor p27KIP1., PMID:34523154
Histone Deacetylase Inhibitor-Induced CDKN2B and CDKN2D Contribute to G2/M Cell Cycle Arrest Incurred by Oxidative Stress in Hepatocellular Carcinoma Cells via Forkhead Box M1 Suppression., PMID:34335925
RNA sequencing reveals potential interacting networks between the altered transcriptome and ncRNome in the skeletal muscle of diabetic mice., PMID:34190986
OIP5-AS1 Promotes Proliferation of Non-small-cell Lung Cancer and Head and Neck Squamous Cell Carcinoma Cells., PMID:34183387
Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy., PMID:34135081
Dual role of EZH2 in megakaryocyte differentiation., PMID:34115825
Radiation-Induced Senescence in p16+/LUC Mouse Lung Compared to Bone Marrow Multilineage Hematopoietic Progenitor Cells., PMID:34087939
RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness., PMID:34004159
Epigallocatechin Gallate Enhances Inhibition Effect of DDP on the Proliferation of Gastric Cancer BGC-823 Cells by Regulating p19Arf-p53-p21Cip1 Signaling Pathway., PMID:33906321
The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1., PMID:33503272
Depletion of Trp53 and Cdkn2a Does Not Promote Self-Renewal in the Mammary Gland but Amplifies Proliferation Induced by TNF-α., PMID:33482103
Adult-type granulosa cell tumor of the ovary: a FOXL2-centric disease., PMID:33428330
Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence., PMID:33356836
Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy., PMID:33046751
[Epigallocatechin gallate induces CHD5 gene demethylation to promote acute myeloid leukemia cell apoptosis in vitro by regulating p19Arf-p53-p21Cip1 signaling pathway]., PMID:32990229
Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes., PMID:32971832
Aflatoxin B1 Induces Neurotoxicity through Reactive Oxygen Species Generation, DNA Damage, Apoptosis, and S-Phase Cell Cycle Arrest., PMID:32899983
Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium., PMID:32806709
Differential manifestation of ocular phenotypes in TALEN-mediated p19arf knockout FVB/N and C57BL/6J mouse lines., PMID:32712838
p19INK4d inhibits proliferation and enhances imatinib efficacy through BCR-ABL signaling pathway in chronic myeloid leukemia., PMID:32711219
BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells., PMID:32594840
IL-23 Promotes a Coordinated B Cell Germinal Center Program for Class-Switch Recombination to IgG2b in BXD2 Mice., PMID:32554431
Chronic Sulforaphane Administration Inhibits Resistance to the mTOR-Inhibitor Everolimus in Bladder Cancer Cells., PMID:32512849
Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer., PMID:32498336
Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse., PMID:32399402
Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells., PMID:32203164
Specific Deletion of p16INK4a with Retention of p19ARF Enhances the Development of Invasive Oral Squamous Cell Carcinoma., PMID:32194051
For research use only. Not for human or drug use.
