Catalog No.
YHF05101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu16-Ala539
Predicted molecular weight
59.37 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P54760
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, HTK, EPHB4, Ephrin type-B receptor 4, TYRO11, MYK1
Cracking the Kinase Code: Urinary Biomarkers as Early Alarms for AAA Rupture-A Pilot Study., PMID:40507607
Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization., PMID:40450304
[Circ_EPHB4 regulates temozolomide sensitivity in glioma cells through the miR-424-5p/Wnt3 axis]., PMID:40415425
Discovery of Novel Multiangiogenic Agents Targeting VEGFR2, EphB4, FGFR-1, and TIE-2: Receptor-Based Pharmacophore Modeling, Virtual Screening, and Molecular Modeling Studies., PMID:40256504
Expression Profiles of Five Common Cancer Membrane Protein Antigens Collected for the Development of Cocktail CAR-T Cell Therapies Applicable to Most Solid Cancer Patients., PMID:40076777
Unusual Presentation of Coronary Artery Fistula in Capillary Malformation Arteriovenous Malformation 2 Syndrome: A Case Report., PMID:40047120
EphB4-ephrin-B2 are targets in castration resistant prostate cancer., PMID:40044981
Feasibility of Intratumoral Administration With EPHB4-CAR-T Cells for the Treatment of Oral Squamous Cell Carcinoma., PMID:40029791
Tensile force promotes osteogenic differentiation via ephrinB2-EphB4 signaling pathway in orthodontic tooth movement., PMID:39844202
Hypoxic Cancer Cells-Derived Exosomes Strengthen the Development of Cancer Stem Cell-Like Properties Through Delivering LINC00665 in Thyroid Cancer Cells., PMID:39831459
Site-Specific Competitive Kinase Inhibitor Target Profiling Using Phosphonate Affinity Tags., PMID:39826875
Inhibition of EphB4 Receptor Signaling by Ephrin-B2-Competitive and Non-Competitive DARPins Prevents Angiogenesis., PMID:39818753
A review of electroacupuncture in bone repair: Mechanisms and clinical implications., PMID:39809159
Swimming induces physiological cardioprotection associated with pro-growth versus anti-inflammatory influences in extracardiac organs., PMID:39792091
PPARβ/δ upregulates the insulin receptor β subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels., PMID:39696437
Biological function of EPHB4 in the aging process of vascular endothelial cells: mtDNA molecular mechanism and MAPK/PGC-1/TFAM signaling pathway., PMID:39653203
EphB4 and ephrin-B1 expression in the intra-testicular-resident macrophages in mice., PMID:39605768
Variations in RASA1 and EPHB4 in Chinese patients with capillary malformation-arteriovenous malformation., PMID:39578666
Germline alteration analysis reveals EPHB4R91H mutation as a key player in multiple primary lung tumors., PMID:39574310
Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC., PMID:39489818
Second Report of the p.Leu874Pro Missense Variant in EPHB4 in a Family With Capillary Malformation-Arteriovenous Malformation Syndrome (CM-AVM) Syndrome., PMID:39431828
EPHB4-RASA1 Inhibition of PIEZO1 Ras Activation Drives Lymphatic Valvulogenesis., PMID:39421925
EphB2, EphB4, and ephrin-B1 expression and localization in postnatal developing epididymis in mice., PMID:39390685
Heterogeneous Kinetics of Nanobubble Ultrasound Contrast Agent and Angiogenic Signaling in Head and Neck Cancer., PMID:39386624
Genotypes and phenotypes of capillary malformation-arteriovenous malformation: characterization and correlation analysis., PMID:39367533
Proteome-wide Mendelian randomization and single-cell sequencing analysis identify the association between plasma proteins and gastric cancer., PMID:39279974
Current trends, molecular insights, and future directions toward precision medicine in the management of pediatric cerebral arteriovenous malformations., PMID:39241253
The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression., PMID:39211197
Identifying novel potential drug targets for endometriosis via plasma proteome screening., PMID:39036049
Osteoclast-derived coupling factors: origins and state-of-play Louis V Avioli lecture, ASBMR 2023., PMID:38990205
Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma., PMID:38985143
Deciphering the shared mechanisms of Gegen Qinlian Decoction in treating type 2 diabetes and ulcerative colitis via bioinformatics and machine learning., PMID:38962743
ED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis., PMID:38716369
Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes., PMID:38585651
Eph-ephrin signaling couples endothelial cell sorting and arterial specification., PMID:38570531
Imbalanced EphB4/EphrinB2 Signaling Modulates Bone Resorption in Periodontitis Induced by Porphyromonas gingivalis., PMID:38442009
Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis., PMID:38231476
ADAMTS13 regulates angiogenic markers via Ephrin/Eph signaling in human mesenchymal stem cells under serum-deprivation stress., PMID:38177376
SAM domain variants of EPHB4 associated with aberrant signaling are linked to lymphatic-related fetal hydrops and facial dysmorphology., PMID:38151336
Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology., PMID:38150042
Unilateral segmental presentation and a novel EPHB4 gene variant in capillary malformation-arteriovenous malformation type 2., PMID:38092051
EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortion†., PMID:38091979
An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves., PMID:38045382
Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations., PMID:37978175
Biological Significance of EphB4 Expression in Cancer., PMID:37909437
Development of an Anti-EphB4 Monoclonal Antibody for Multiple Applications Against Breast Cancers., PMID:37824755
In-silico and structure-based assessment to evaluate pathogenicity of missense mutations associated with non-small cell lung cancer identified in the Eph-ephrin class of proteins., PMID:37813626
An oral triple pill-based cocktail effectively controls acute myeloid leukemia with high translation., PMID:37778270
Understanding the pathogenesis of brain arteriovenous malformation: genetic variations, epigenetics, signaling pathways, and immune inflammation., PMID:37768356
Temporospatial inhibition of Erk signaling is required for lymphatic valve formation., PMID:37691058
For research use only. Not for human or drug use.
