Catalog No.
YHF04201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly174-Ser386
Predicted molecular weight
25.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P54687
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein ECA39, BCAT1, BCT1, ECA39, Branched-chain-amino-acid aminotransferase, cytosolic, BCAT(c)
Proteomic analysis reveals potential biomarker candidates in serous ovarian tumors - a preliminary study., PMID:40330446
Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis., PMID:40290517
Circulating DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer., PMID:40253416
Circulating Tumor DNA in Addition to Fecal Immunochemical Test in a Dual-Test Colorectal Cancer Screening Approach., PMID:40204621
SIRT5-mediated BCAT1 desuccinylation and stabilization leads to ferroptosis insensitivity and promotes cell proliferation in glioma., PMID:40195331
BCAT2 Expression in IDC Breast Cancer subtypes: A Weighted Feature-Based Approach to Identify and Rank Associated Genes Across Public Datasets., PMID:40039929
Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors., PMID:40005214
NR4A1 deficiency promotes carotid plaque vulnerability by activating integrated stress response via targeting Bcat1., PMID:39985585
Inhibition of Bif-1 confers cardio-protection in myocardial infarction., PMID:39982446
BCAT1 Associates with DNA Repair Proteins KU70 and KU80 and Contributes to Regulate DNA Repair in T-Cell Acute Lymphoblastic Leukemia (T-ALL)., PMID:39769333
Identification of common core genes and pathways in childhood sepsis and cancer by bioinformatics analysis., PMID:39636505
Small-molecule targeting BCAT1-mediated BCAA metabolism inhibits the activation of SHOC2-RAS-ERK to induce apoptosis of Triple-negative breast cancer cells., PMID:39490614
Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia., PMID:39455853
Ultrasensitive Amplification-Free Quantification of a Methyl CpG-Rich Cancer Biomarker by Single-Molecule Kinetic Fingerprinting., PMID:39425638
BCAT1 contributes to the development of TKI-resistant CML., PMID:39412615
Inhibition of BCAT1 expression improves recurrent miscarriage by regulating cellular dysfunction and inflammation of trophoblasts., PMID:39356334
Identify BCAT1 plays an oncogenic role and promotes EMT in KIRC via single cell RNA-seq and experiment., PMID:39324007
Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism., PMID:39255038
Widely Untargeted Metabolomics Profiling Combined with Transcriptome Analysis Provides New Insight into Amino Acid Biosynthesis at Different Developmental Stages of Rubus Chingii Hu (Chinese Raspberry)., PMID:39254678
BCAT1 is a NOTCH1 target and sustains the oncogenic function of NOTCH1., PMID:39234857
DUSP6 protein action and related hub genes prevention of sepsis-induced lung injury were screened by WGCNA and Venn., PMID:39197622
A blood test measuring DNA methylation of BCAT1 and IKZF1 for detection of lung adenocarcinoma., PMID:39154541
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation., PMID:39143065
Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1α pathway., PMID:39085353
CHIP-mediated ubiquitin degradation of BCAT1 regulates glioma cell proliferation and temozolomide sensitivity., PMID:39075053
BCAT1 promotes cell proliferation, migration, and invasion via the PI3K-Akt signaling pathway in oral squamous cell carcinoma., PMID:39056279
Reprogramming of Energy Metabolism in Human PKD1 Polycystic Kidney Disease: A Systems Biology Analysis., PMID:39000280
Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity., PMID:38993559
A novel amino acid metabolism-related gene signature to predict the overall survival of esophageal squamous cell carcinoma patients., PMID:38983159
Transcription factor EB reprograms branched-chain amino acid metabolism and promotes pancreatic cancer progression via transcriptional regulation of BCAT1., PMID:38938061
BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage., PMID:38871197
Targeting IGF2BP1 alleviated benzene hematotoxicity by reprogramming BCAA metabolism and fatty acid oxidation., PMID:38866309
RUNX1::ETO and CBFβ::MYH11 converge on aberrant activation of BCAT1 to confer a therapeutic vulnerability in core-binding factor-acute myeloid leukaemia., PMID:38802066
BCAT1, IKZF1 and SEPT9: methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas., PMID:38644767
Strategies to improve CHO cell culture performance: Targeted deletion of amino acid catabolism and apoptosis genes paired with growth inhibitor supplementation., PMID:38629737
Cross-talk between BCKDK-mediated phosphorylation and STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM progression., PMID:38621458
Metabolic remodeling by the PD-L1 inhibitor BMS-202 significantly inhibits cell malignancy in human glioblastoma., PMID:38438374
Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans., PMID:38418585
HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1., PMID:38369471
High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response., PMID:38340163
Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma., PMID:38309289
Diagnostic value of methylated branched chain amino acid transaminase 1/IKAROS family zinc finger 1 for colorectal cancer., PMID:37901447
The role of branched-chain aminotransferase 1 in driving glioblastoma cell proliferation and invasion varies with tumor subtype., PMID:37885806
Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression., PMID:37769206
Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood., PMID:37710283
Knockdown of PRMT1 suppresses the malignant biological behavior of osteosarcoma cells and increases cisplatin sensitivity via c-Myc-mediated BCAT1 downregulation., PMID:37700640
Integration of Single-Cell RNA Sequencing and Bulk RNA Sequencing Reveals That TAM2-Driven Genes Affect Immunotherapeutic Response and Prognosis in Pancreatic Cancer., PMID:37628967
Prognostic impact of FLT3-ITD mutation on NPM1+ acute myeloid leukaemia patients and related molecular mechanisms., PMID:37621257
MiR-320a Acts as a Tumor Suppressor in Somatotroph Pituitary Neuroendocrine Tumors by Targeting BCAT1., PMID:37591221
Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression., PMID:37337119
For research use only. Not for human or drug use.
