Catalog No.
YHF04001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg552
Predicted molecular weight
64.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P54646
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRKAA2, Acetyl-CoA carboxylase kinase, AMPK subunit alpha-2, ACACA kinase, AMPK, AMPK2, Hydroxymethylglutaryl-CoA reductase kinase, 5'-AMP-activated protein kinase catalytic subunit alpha-2, HMGCR kinase
4D label-free quantitative proteomic and phosphoproteomic profiling of the kidney in rat models of antimyeloperoxidase-associated vasculitis., PMID:40201969
Role of AMPKα2 in regulating the IRE1α-JNK pathway in metabolic dysfunction-associated fatty liver disease., PMID:40195661
Deubiquitinase USP18 mediates cell migration, apoptosis and ferroptosis in lung adenocarcinoma by depending on POU4F1/PRKAA2 axis., PMID:40122823
AMPK in Chemoradiotherapy-Induced Oral Mucositis., PMID:40091685
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling., PMID:40088888
Phosphorylation of BCL2L13 by PRKAA2/AMPKα2 activates mitophagy in pressure-overloaded heart., PMID:39995141
Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia., PMID:39961478
Cardiomyocyte PRL2 Promotes Cardiac Hypertrophy via Directly Dephosphorylating AMPKα2., PMID:39950300
Analysis of long noncoding gene expression and its interactions with protein-coding genes in vascular endothelial cells in keloids., PMID:39920823
AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease., PMID:39832686
Reduced lipid and glucose oxidation and reduced lipid synthesis in AMPKα2-/- myotubes., PMID:39781899
The Combination of Resveratrol and Conjugated Linoleic Acid Dienes Enhances the Individual Effects of These Molecules on De Novo Fatty Acid Biosynthesis in 3T3-L1 Adipocytes., PMID:39769194
Neonatal body composition, salivary feeding gene expression, and feeding outcomes in infants of diabetic mothers., PMID:39749266
PRKAA2 Promotes Tumor Growth and Inhibits Ferroptosis through SLC7A11/GSH/GPX4 Pathway in Non-Small Cell Lung Cancer., PMID:39722125
Enhanced autophagy and cholesterol efflux in mouse mesenchymal stem cells infected with H37Rv compared to H37Ra., PMID:39653283
AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection., PMID:39580803
Huangqi-Danshen decoction improves heart failure by regulating pericardial adipose tissue derived extracellular vesicular miR-27a-3p to activate AMPKα2 mediated mitophagy., PMID:39488874
Dorsomedial Ventromedial Hypothalamic Nucleus Growth Hormone-Releasing Hormone Neuron Steroidogenic Factor-1 Gene Targets in Female Rat., PMID:39401164
PRKAA2-mediated mitophagy regulates oxygen consumption in yak renal tubular epithelial cells under chronic hypoxia., PMID:39396565
Metabolic reprogramming and AMPK activation: Key players in the therapeutic effects of Cooling Blood and Detoxicating Formular on psoriasis., PMID:39278294
Comparative Effects of Tumor Necrosis Factor Alpha, Lipopolysaccharide, and Palmitate on Mitochondrial Dysfunction in Cultured 3T3-L1 Adipocytes., PMID:39269560
Astragaloside IV intervenes multi-regulatory cell death forms against doxorubicin-induced cardiotoxicity by regulating AMPKα2 pathway., PMID:39236461
Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology., PMID:39136022
PAK4 phosphorylates and inhibits AMPKα to control glucose uptake., PMID:39127697
Variances in the Expression Profile of Circadian Clock-Related Genes in Astrocytic Brain Tumors., PMID:39001398
Melatonin regulates microglial M1/M2 polarization via AMPKα2-mediated mitophagy in attenuating sepsis-associated encephalopathy., PMID:38976956
SIRT5-mediated PRKAA2 succinylation ameliorates apoptosis of human placental trophoblasts in hypertensive disorder complicating pregnancy., PMID:38785262
Myeloid AMPK signaling restricts fibrosis but is not required for metformin improvements during CDAHFD-induced NASH in mice., PMID:38762124
Sex-Dimorphic Effects of Hypoglycemia on Metabolic Sensor mRNA Expression in Ventromedial Hypothalamic Nucleus-Dorsomedial Division (VMNdm) Growth Hormone-Releasing Hormone Neurons., PMID:38757688
Role of autophagy-related genes in liver cancer prognosis., PMID:38703969
Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging., PMID:38654312
SubSol-HIe is an AMPK-dependent hypoxia-responsive subnucleus of the nucleus tractus solitarius that coordinates the hypoxic ventilatory response and protects against apnoea in mice., PMID:38635058
Floralozone regulates MiR-7a-5p expression through AMPKα2 activation to improve cognitive dysfunction in vascular dementia., PMID:38458310
AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma., PMID:38424484
AMPKα2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradation., PMID:38242911
Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function., PMID:38227383
PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy., PMID:38183492
[Mechanism of miR-186-5p Regulating PRKAA2 to Promote Ferroptosis
in Lung Adenocarcinoma Cells]., PMID:38061883
Ameliorative effects of Modified Huangqi Chifeng decoction on podocyte injury via autophagy mediated by PI3K/AKT/mTOR and AMPK/mTOR pathways., PMID:38042389
ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA., PMID:38016036
Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers., PMID:37962491
Quantitative Proteomics Characterization of the Effect and Mechanism of Trichostatin A on the Hippocampus of Type II Diabetic Mice., PMID:37864628
Anti-ferroptotic PRKAA2 serves as a potential diagnostic and prognostic marker for hepatoblastoma., PMID:37720445
Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease., PMID:37700498
RNA-Seq transcriptomic landscape profiling of spontaneously hypertensive rats treated with a sodium-glucose cotransporter 2 (SGLT2) inhibitor., PMID:37572641
Loss of AMPKα2 promotes melanoma tumor growth and brain metastasis., PMID:37213225
Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice., PMID:37156612
Genomic adaptation to extreme climate conditions in beef cattle as a consequence of cross-breeding program., PMID:37024818
FTO-mediated m6A demethylation of pri-miR-3591 alleviates osteoarthritis progression., PMID:37005694
Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis., PMID:36685512
For research use only. Not for human or drug use.
