Catalog No.
YHF02701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp879-Leu1190
Predicted molecular weight
36.82 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P54259
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Atrophin-1, DRPLA, ATN1, D12S755E, Dentatorubral-pallidoluysian atrophy protein
Accurate Quantification of Mutant and Wild-Type polyQ Proteins Using Simple Western Capillary Immunoassays., PMID:40450087
The nuclear export signal mediates mutant atrophin-1-induced neuropathology in a mouse model of DRPLA., PMID:40263757
Insights into dentatorubral-pallidoluysian atrophy from a new Drosophila model of disease., PMID:39921111
ATXN10 Gene Expansions in Mexican Patients with Ataxia Without Epilepsy., PMID:39820777
Insights into Dentatorubral-Pallidoluysian Atrophy from a new Drosophila model of disease., PMID:39713465
Identification of pivotal genes and pathways in Chorea-acanthocytosis using comprehensive bioinformatic analysis., PMID:39292690
Dentatorubral-pallidoluysian atrophy: a case report and review of literature., PMID:39238050
IRF2BPL-Related Disorder, Causing Neurodevelopmental Disorder with Regression, Abnormal Movements, Loss of Speech and Seizures (NEDAMSS) Is Characterized by Pathology Consistent with DRPLA., PMID:39224955
Overexpanded CAG repeats in ATN1 cause an Early-Onset Case of Dentatorubral-Pallidoluysian atrophy with novel phenotypes and a literature Review of Chinese patients., PMID:39181274
Differential microRNA expression in the SH-SY5Y human cell model as potential biomarkers for Huntington's disease., PMID:39049823
Dentatorubral-pallidoluysian atrophy: a rare cause of epilepsy, ataxia and chorea., PMID:38981679
Establishing resources and increasing awareness to advance research on Dentatorubral-pallidoluysian atrophy toward a treatment: a patient organization perspective., PMID:38716233
The importance of routine genetic testing in pediatric epilepsy surgery., PMID:38366963
ATN1-related infantile developmental and epileptic encephalopathy responding to Ketogenic diet., PMID:38262122
The FAT1 Cadherin Drives Vascular Smooth Muscle Cell Migration., PMID:37371091
Atrophin-1 Function and Dysfunction in Dentatorubral-Pallidoluysian Atrophy., PMID:36809552
Uba1: A Potential Ubiquitin-like Activator Protein of Urm1 in Toxoplasma gondii., PMID:36142209
CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1., PMID:35836803
Identification of epilepsy concomitant candidate genes recognized in Saudi epileptic patients., PMID:35363364
DNA methylation age acceleration is associated with age of onset in Chinese spinocerebellar ataxia type 3 patients., PMID:35247757
Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study., PMID:35182509
Fragment-based exploration of the 14-3-3/Amot-p130 interface., PMID:35036934
CAG repeat-binding small molecule improves motor coordination impairment in a mouse model of Dentatorubral-pallidoluysian atrophy., PMID:34968706
DRPLA: An unusual disease or an underestimated cause of ataxia in Brazil?, PMID:34700111
Pallidal degenerations and related disorders: an update., PMID:34363531
CHEDDA syndrome is an underrecognized neurodevelopmental disorder with a highly restricted ATN1 mutation spectrum., PMID:34212383
The rare and the common: An Austrian DRPLA family harboring the European haplotype., PMID:34022586
The PHD transcription factor Cti6 is involved in the fungal colonization and aflatoxin B1 biological synthesis of Aspergillus flavus., PMID:34006318
Coexistence of dentatorubral-pallidoluysian atrophy and Parkinson's disease: An autopsy case report., PMID:33851459
Maternal sevoflurane exposure affects differentiation of hippocampal neural stem cells by regulating miR-410-3p and ATN1., PMID:32993796
Investigations of Huntington's Disease and Huntington's Disease-Like Syndromes in Indian Choreatic Patients., PMID:32675418
Structure and Dynamics of a Thermostable Alcohol Dehydrogenase from the Antarctic Psychrophile Moraxella sp. TAE123., PMID:32596590
ITCH as a potential therapeutic target in human cancers., PMID:32165318
Universal RNAi Triggers for the Specific Inhibition of Mutant Huntingtin, Atrophin-1, Ataxin-3, and Ataxin-7 Expression., PMID:31927329
Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins., PMID:31767406
Fat cadherins in mouse models of degenerative ataxias., PMID:31695130
Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans., PMID:31645584
Generation of induced pluripotent stem cell line CSSi008-A (4698) from a patient affected by advanced stage of Dentato-Rubral-Pallidoluysian atrophy (DRPLA)., PMID:31493762
Generation of human iPS cell line IBCHi001-A from dentatorubral-pallidoluysian atrophy patient's fibroblasts., PMID:31374462
[Pathogenic gene variants and clinical phenotype features of 26 children with progressive myoclonic epilepsy]., PMID:31216804
Calhex231 Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro., PMID:31167987
(CAG)n loci as genetic modifiers of age at onset in patients with spinocerebellar ataxia type 1 from mainland China., PMID:30891880
De Novo Variants Disrupting the HX Repeat Motif of ATN1 Cause a Recognizable Non-Progressive Neurocognitive Syndrome., PMID:30827498
Integrated machine learning pipeline for aberrant biomarker enrichment (i-mAB): characterizing clusters of differentiation within a compendium of systemic lupus erythematosus patients., PMID:30815180
EvoPPI 1.0: a Web Platform for Within- and Between-Species Multiple Interactome Comparisons and Application to Nine PolyQ Proteins Determining Neurodegenerative Diseases., PMID:30707359
Large normal alleles of ATXN2 decrease age at onset in transthyretin familial amyloid polyneuropathy Val30Met patients., PMID:30615214
Dentatorubral-pallidoluysian Atrophy: An Update., PMID:30410817
Repeat length variations in ATXN1 and AR modify disease expression in Alzheimer's disease., PMID:30314815
1H, 13C, and 15N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH., PMID:30229450
For research use only. Not for human or drug use.
