Catalog No.
YHF01601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Trp1041-Pro1239
Predicted molecular weight
24.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P54098
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
POLG, Mitochondrial DNA polymerase catalytic subunit, POLGA, PolG-alpha, POLG1, DNA polymerase subunit gamma-1, MDP1
DJ-1 deficiency and aging: dual drivers of retinal mitochondrial dysfunction., PMID:40475680
Delineating the mechanisms of cerebellar degeneration in paediatric and adult primary mitochondrial disease., PMID:40445405
Identification of common hub genes and construction of immune regulatory networks in aplastic anemia, myelodysplastic syndromes, and acute myeloid leukemia., PMID:40406144
Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity., PMID:40404629
PARylation of POLG Mediated by PARP1 Accelerates Ferroptosis-Induced Vascular Calcification via Activating Adora2a/Rap1 Signaling., PMID:40401372
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease., PMID:40393978
[Morphological markers of mitochondrial dysfunction of the basal plate cytotrophoblast of the placenta in preeclampsia of varying severity]., PMID:40289429
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability., PMID:40238457
Knockdown of POLG Mimics the Neuronal Pathology of Polymerase-γ Spectrum Disorders in Human Neurons., PMID:40214434
Small molecules restore mutant mitochondrial DNA polymerase activity., PMID:40205042
Investigating the safety and efficacy of deoxycytidine/deoxythymidine in mitochondrial DNA depletion disorders: phase 2 open-label trial., PMID:40175578
Chromogen-based double immunohistochemical detection of mitochondrial respiratory chain deficiencies in human brain tissue., PMID:40114250
Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle., PMID:40057508
The POLG Variant c.678G>C; p.(Gln226His) Is Associated with Mitochondrial Abnormalities in Fibroblasts Derived from a Patient Compared to a First-Degree Relative., PMID:40004527
GDF15 Neutralization Ameliorates Muscle Atrophy and Exercise Intolerance in a Mouse Model of Mitochondrial Myopathy., PMID:39976232
Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation., PMID:39952317
Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes., PMID:39903101
Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance., PMID:39890960
Integrated Analysis of Polymerase Family Gene Mutations in Acute Myeloid Leukemia: Clinical Features, Prognosis, and Bioinformatics Insights., PMID:39768855
Somatic mtDNA mutation burden shapes metabolic plasticity in leukemogenesis., PMID:39742470
Analysis of mitochondrial DNA replisome in autism spectrum disorder: Exploring the role of replisome genes., PMID:39611328
POLG p.A962T Mutation Leads to Neuronal Mitochondrial Dysfunction That is Restored After Mitochondrial Transplantation., PMID:39545794
[Expanded carrier screening for 216 diseases in a cohort of 3 097 healthy Chinese individuals of childbearing age]., PMID:39463360
Longitudinal Analysis of Natural History Progression of Rare and Ultra-Rare Cerebellar Ataxias Using Item Response Theory., PMID:39403821
'The phenotypic conundrum of Trp748Ser variant in POLG gene: a report of two patients'., PMID:39342053
Gene-based drug therapy for children and youth treated with psychoactive medications., PMID:39281359
Modeling aging and retinal degeneration with mitochondrial DNA mutation burden., PMID:39210608
POLG epilepsy presenting as new-onset refractory status epilepticus (NORSE) in pregnancy., PMID:39209381
POLG-related mitochondrial disease mimicking autoimmune encephalitis., PMID:39180587
The clinical and genetic spectrum of mitochondrial diseases in China: A multicenter retrospective cross-sectional study., PMID:39118480
Exploring the roles of RNAs in chromatin architecture using deep learning., PMID:39075082
PINK1 regulated mitophagy is evident in skeletal muscles., PMID:38988500
Distinct Clinical Courses and Shortened Lifespans in Childhood-Onset DNA Polymerase Gamma Deficiency., PMID:38975049
Coordinated DNA polymerization by Polγ and the region of LonP1 regulated proteolysis., PMID:38932681
Mitochondrial DNA Instability Supersedes Parkin Mutations in Driving Mitochondrial Proteomic Alterations and Functional Deficits in Polg Mutator Mice., PMID:38928146
Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation., PMID:38904024
Epidemiology and natural history of POLG disease in Norway: a nationwide cohort study., PMID:38845467
Status epilepticus in POLG disease: a large multinational study., PMID:38822839
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease., PMID:38798587
Polyradiculoneuritis on MRI: An Overlooked Feature of Biallelic POLG Gene Mutations in Infancy., PMID:38754044
Genetic evaluation in indeterminate acute liver failure: A post hoc analysis., PMID:38705812
Oculomasticatory rhythmic movements, insomnia and stroke-like episodes in a patient with POLG mutation., PMID:38684350
Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment., PMID:38643274
Ancestral allele of DNA polymerase gamma modifies antiviral tolerance., PMID:38570685
Clinical-Genomic Analysis of 1261 Patients with Ehlers-Danlos Syndrome Outlines an Articulo-Autonomic Gene Network (Entome)., PMID:38534782
AMPK Suppression Due to Obesity Drives Oocyte mtDNA Heteroplasmy via ATF5-POLG Axis., PMID:38499990
Bioinformatics approach for prediction and analysis of the Non-Structural Protein 4B (NSP4B) of the Zika virus., PMID:38494248
Genetic heterogeneity and respiratory chain enzyme analysis in pediatric Indian patients with mitochondrial disorder: Report of novel variants in POLG1 gene and their functional implication using molecular dynamic simulation., PMID:38471579
Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids., PMID:38445970
Absence of both MGME1 and POLG EXO abolishes mtDNA whereas absence of either creates unique mtDNA duplications., PMID:38432635
For research use only. Not for human or drug use.
